GIT1 is an untolerized autoantigen involved in immunologic disturbance of spermatogenesis

Nagahori, Kaoru; Kuramasu, Miyuki; Kawata, Sumio; Yakura, Tomiko; Li, Zhong‐Lian; Hirai, Shuichi; Qu, Ning; Itoh, Masahiro

doi:10.1007/s00418-021-02061-1

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…As shown in Figure 4E, MA@PDA-F127 captured tumor antigens (including Eif2a, Fubp1, Hspa4l), DAMPs (including Hspa14, Hsph1, Mthfd1), and immune factors (including H2-Q10, Nipsnap2, and plcg2). [30][31][32][33][34][35] These immune-activating proteins were expected to recruit and activate DCs, and shape a favorable microenvironment for antitumor immunity.…”

Section: Antigens Capture and Immune Stimulation Capability Of Ma@pda...mentioning

confidence: 99%

Engineered Microcystis aerugiosa Hydrogel as an Anti‐Tumor Therapeutic by Augmenting Tumor Immunogenicity and Immune Responses

Meng,

Liu,

Yang

et al. 2023

Adv Funct Materials

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Cancer immunotherapy holds great promise but is generally limited by insufficient induction of anticancer immune responses. In this work, Microcystis aerugiosa (MA) is observed to act as an immune stimulator, which activates the cGAS‐STING and IRF‐signaling pathways of dendritic cells (DCs), induces immunostimulatory factors production, eventually resulting in the death of tumor cells by promoting cytotoxic CD8+ T cells infiltration. To further enhance the tumor immunogenicity, MA is engineered with polydopamine (PDA) and assembled in injectable Pluronic F127 hydrogels (denoted as MA@PDA‐F127). The introduction of PDA endows the MA@PDA‐F127 with photothermal therapy capability, which enhances the immunogenicity by in situ exposing damage‐associated molecular patterns and tumor antigens from dying tumor cells. Importantly, the surface‐rich reaction sites in thermosensitive MA@PDA‐F127 hydrogels capture antigens, facilitating long retention of antigens exposure and enhancing DCs maturation for advanced anti‐tumor immune response. Accordingly, in situ administration of MA@PDA‐F127 hydrogels in a single dose achieves efficient eradication of both primary and distant tumors in an orthotopic tumor metastasis model. Furthermore, this hydrogel can sensitize immune checkpoint inhibitor therapy and enhance T cell infiltration in a murine tumor model. Collectively, MA@PDA‐F127 hydrogel offers an effective anti‐tumor therapeutic by augmenting tumor immunogenicity and activating a systematic immune response.

show abstract

Section: Antigens Capture and Immune Stimulation Capability Of Ma@pda...mentioning

confidence: 99%

Engineered Microcystis aerugiosa Hydrogel as an Anti‐Tumor Therapeutic by Augmenting Tumor Immunogenicity and Immune Responses

Meng,

Liu,

Yang

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…This model may reveal the precise mechanisms of cryptorchidism and new knowledge of meiosis. Nagahori et al (2022) established a model of immunologic male infertility using G protein-coupled receptor kinase interacting protein-1 in mice. Successful generation of experimental autoimmune orchitis will be helpful to understand the pathogenesis of immunologic male infertility, and it could provide a basis for the development of novel diagnosis and therapy for autoimmunity-based disturbance of spermatogenesis.…”

Section: Male Partmentioning

confidence: 99%