Girdin regulates both migration and angiogenesis in pancreatic cancer cell lines

Hayashi, Yuichi; Matsuo, Yoichi; Denda, Yuki; Nonoyama, Keisuke; Murase, Hiromichi; Ueda, Gaiko; Aoyama, Yuichi; Kato, Toyonori; Omi, Kan; Imafuji, Hiroyuki; Saito, Kenta; Morimoto, Mamoru; Ogawa, Ryo; Takahashi, Hiroki; Mitsui, Akira; Kimura, Masahiro; Takiguchi, Shuji

doi:10.3892/or.2023.8606

Cited by 1 publication

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Girdin is an actin-binding protein, that is involved in cancer invasion and angiogenesis, and is a prognostic biomarker. Girdin can participate in pancreatic cancer (PaCa) migration mediated by EGF signal, and SCU can inhibit cancer invasion by inhibiting Girdin, thus playing a role in anti-cancer [ 62 ]. Li et al used an aminoethyl anisamide-targeted copolymerization approach to amplify the delivery capacity of scutellarin to facilitate the in vivo application of scutellarin in hepatocellular carcinoma (HCC) immunotherapy and demonstrated that scutellarin has the potential to trigger immunogenic cell death (ICD) in hepatocellular carcinoma HCC [ 63 ] ).…”

Section: Pharmacological Effectsmentioning

confidence: 99%

Current advances on the therapeutic potential of scutellarin: an updated review

Xie,

Sun,

Tao

et al. 2024

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

Scutellarin is widely distributed in Scutellaria baicalensis, family Labiatae, and Calendula officinalis, family Asteraceae, and belongs to flavonoids. Scutellarin has a wide range of pharmacological activities, it is widely used in the treatment of cerebral infarction, angina pectoris, cerebral thrombosis, coronary heart disease, and other diseases. It is a natural product with great research and development prospects. In recent years, with in-depth research, researchers have found that wild scutellarin also has good therapeutic effects in anti-tumor, anti-inflammatory, anti-oxidation, anti-virus, treatment of metabolic diseases, and protection of kidney. The cancer treatment involves glioma, breast cancer, lung cancer, renal cancer, colon cancer, and so on. In this paper, the sources, pharmacological effects, in vivo and in vitro models of scutellarin were summarized in recent years, and the current research status and future direction of scutellarin were analyzed. Graphical Abstract

show abstract

Section: Pharmacological Effectsmentioning

confidence: 99%