Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate

Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis

“…The traditional beneficial effects of ginseng are replenishment of vital energy, longevity and mood elevation [15] . The molecular constituents responsible for the action of ginseng are ginsenosides, among which, Rg1 is the most abundant and active ingredient of P ginseng [14,16] . Several studies have shown that Rg1 or ginseng extract has a liver protective effect [16][17][18][19][20][21][22] .…”

Ginsenoside Rb1 selectively inhibits the activity of L-type voltage-gated calcium channels in cultured rat hippocampal neurons

“…Most studies support the effect of Rb1 in preventing neuronal death linked to neurodegenerative diseases [13,15,28,29] . Its perturbed neuronal Ca 2+ homeostasis is implicated in aging and age-related cognitive impairments [12] .…”

“…Ginsenoside Rb1, a protopanaxadiol type saponin, is one of the most important active compounds of ginseng. Recently, ginsenoside Rb1 has been reported to effectively protect neurons from glutamate-induced toxicity and β-amyloid (Aβ)-induced toxicity by reducing intracellular Ca 2+ levels [13][14][15][16][17][18] . However, how Rb1 decreases [Ca 2+ ] i by regulating Ca 2+ channels remains unclear.…”

Simian immunodeficiency virus vector pseudotypes differ in transduction efficiency and target cell specificity in brain

“…Brains of the embryos were excised and primary cell cultures were prepared according to Radad et al 55 Briefly, after excision of the ventral mesencephala, the meninges were carefully removed and tissues were mechanically cut into small pieces in PBS and subsequently triturated with a fire-polished Pasteur pipette in DMEM. Dissociated cells were resuspended in DMEM containing 10% FCS, 25 mM Hepes, 2 mM glutamine and 30 mM glucose.…”