Ginsenoside Rp1 Inhibits Proliferation and Migration of Human Lung Cancer Cells

Hong, Sam-Yeol; Cho, Jae-Youl; Seo, Dong Wan

doi:10.4062/biomolther.2011.19.4.411

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…The RUNX3 gene is frequently inactivated through histone modification during �� p�� f �� , �� colon (20,(22)(23)(24)(25) (27). A ��b�� f ��p�� b�� f�� and their possible antitumor activity has been extensively investigated in various cancer cell lines (28)(29)(30). Among these ��p��, 20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol, or Compound K, is the main metabolite of protopanaxadiol-type ��, f�� f�� (31)(32)(33).…”

Section: Compound K a Metabolite Of Ginseng Saponin Inhibits Colorementioning

confidence: 99%

Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity

Kang

Piao

Kim

et al. 2013

International Journal of Oncology

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In this study, we investigated the molecular mechanisms underlying the anti-proliferative effects of Compound K, with specific reference to histone modification. Exposure of HT-29 human colon cancer cells to Compound K resulted in time-dependent inhibition of histone deacetylase (HDAC) activity, mRNA and protein expression. Compound K treatment induced unmethylation of the RUNX3 promoter region such as TSA treatment and an accumulation of acetylated histones H3 and H4 within the total cellular chromatin, resulting in an enhanced ability of these histones to bind to the promoter sequences of the tumor suppressor gene Runt-related transcription factor 3 (RUNX3). Treatment of cells with Compound K increased the mRNA and protein expression of RUNX3, as well as p21, a downstream target of RUNX3. These alterations were consistent with cell cycle arrest at the G0/G1 phases and induction of apoptosis. Our results provide new insights into the mechanisms of Compound K action in human colorectal cancer cells and suggest that HDAC inhibition presents a novel approach to prevent or treat colorectal cancer.

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Section: Compound K a Metabolite Of Ginseng Saponin Inhibits Colorementioning

confidence: 99%

Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity

Kang

Piao

Kim

et al. 2013

International Journal of Oncology

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“…Zymogram analysis. Activities of matrix metalloproteinases (MMPs) were measured by zymography (21,26). Aliquots of conditioned medium were diluted in sample buffer, applied to 10% polyacrylamide gels containing 1 mg/ml gelatin (Sigma-Aldrich Co.) as a substrate.…”

Section: Cellmentioning

confidence: 99%

The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signaling pathways

Cho

Choi²,

Seo

2013

Oncology Reports

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Siegesbeckia glabrescens (SG) Makino (Compositae) has been used as a traditional medicine for the treatment of a variety of diseases such as allergy, inflammation, acute hepatitis and hypertension. The primary aim of this study was to determine whether the ethanol extract of SG has antitumor activity against ovarian cancer and to identify molecular mechanisms and targets involved in the regulation of cell growth and progression. We demonstrate that SG treatment inhibits proliferation, adhesion, migration and invasion of SKOV-3 human ovarian cancer cells. The anti-proliferative effect of SG on SKOV-3 cells is accompanied by reduced expression of cyclin E and enhanced expression of the cyclin-dependent kinase inhibitor p27(Kip1), leading to inhibition of pRb phosphorylation. We also show that these antitumor activities are found to be mediated through suppression of FAK, ERK, Akt and p70(S6K)-dependent signaling pathways and downregulation of receptor tyrosine kinases such as EGFR, VEGFR-2 and FGFR-1 as well as the cell adhesion molecule N-cadherin. Taken together, our findings suggest further development and evaluation of SG for the treatment of ovarian cancer.

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“…Activities of matrix metalloproteinases were measured by zymography (19). Aliquots of conditioned medium were diluted in sample buffer, applied to 10% polyacrylamide gels containing 1 mg/ml gelatin (SigmaAldrich Co.) as a substrate.…”

Section: Cellmentioning

confidence: 99%

Knockdown of integrin α3β1 expression induces proliferation and migration of non-small cell lung cancer cells

Yoon¹,

Cho²,

Joo³

et al. 2012

Oncology Reports

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Abstract. Integrin α3β1 is expressed on many types of cancer cells and can regulate tumor growth and progression. In the present study, we examined the roles and molecular mechanism of integrin α3β1 in modulating cell proliferation and migration of p53-deficient non-small cell lung cancer (NSCLC) cells. Reduced expression of integrin α3 by RNA silencing clearly induces cell proliferation and migration in H1299 cells, compared with those in control cells. Enhanced proliferation in integrin α3-silenced cells is mediated by upregulation and nuclear localization of cyclin-dependent kinases, and these effects require the activation of Akt and ERK as evidenced by treatment with LY294002 and PD98059, respectively. Furthermore, suppression of integrin α3 expression induces the expression of nuclear factor-κB and Bcl-2 as well as epidermal growth factor receptor, which are positively correlated with cell proliferation and survival. In contrast, increase in cell migration of integrin α3-silenced cells is found to be independent of Akt or ERK signaling pathways. Collectively, these findings suggest that integrin α3β1 plays pivotal roles in regulating cell proliferation and migration that enhance the invasive type of p53-deficient NSCLC cells.

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Ginsenoside Rp1 Inhibits Proliferation and Migration of Human Lung Cancer Cells

Cited by 7 publications

References 40 publications

Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity

Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity

The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signaling pathways

Knockdown of integrin α3β1 expression induces proliferation and migration of non-small cell lung cancer cells

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