2013
DOI: 10.4062/biomolther.2013.053
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Ginsenoside Rg3 Alleviates Lipopolysaccharide-Induced Learning and Memory Impairments by Anti-Inflammatory Activity in Rats

Abstract: The purpose of this study was to examine whether ginsenoside Rg3 (GRg3) could improve learning and memory impairments and inflammatory reactions induced by injecting lipopolysaccharide (LPS) into the brains of rats. The effects of GRg3 on proinflammatory mediators in the hippocampus and the underlying mechanisms of these effects were also investigated. Injection of LPS into the lateral ventricle caused chronic inflammation and produced deficits in learning in a memory-impairment animal model. Daily administrat… Show more

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Cited by 83 publications
(71 citation statements)
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References 50 publications
(72 reference statements)
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“…Many studies have been reporting that Rg3 exhibits in vitro and in vivo anticarcinogenic and antimetastatic effects and also Rg3 exerted inhibitory effect on proliferation, capillary tube formation, and invasion of human umbilical vein endothelial cells (HUVEC) [5961]. In addition, Rg3 has anti-inflammatory effects by inhibiting COX-2, iNOS expression, and proinflammatory cytokines production in LPS-induced cells [47, 48]. …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Many studies have been reporting that Rg3 exhibits in vitro and in vivo anticarcinogenic and antimetastatic effects and also Rg3 exerted inhibitory effect on proliferation, capillary tube formation, and invasion of human umbilical vein endothelial cells (HUVEC) [5961]. In addition, Rg3 has anti-inflammatory effects by inhibiting COX-2, iNOS expression, and proinflammatory cytokines production in LPS-induced cells [47, 48]. …”
Section: Discussionmentioning
confidence: 99%
“…Ginsenoside Rg3 (Rg3) is the main component of RG [46]. Many studies have reported that Rg3 has an anti-inflammatory effect by reducing COX-2, inducible nitric oxide synthase (iNOS), and proinflammatory cytokines, including TNF- α and IL-1 β expression, induced by LPS stimulation in vitro [4749]. However, there is no study of the effects of Rg3 on human inflammation induced airway epithelial cells and human asthmatic airway epithelial tissue.…”
Section: Introductionmentioning
confidence: 99%
“…This finding was supported by decreasing the time latency to enter the dark compartment and enhancing the total time spent in dark room and reducing the total time spent in light room in LPS group in comparison with control group. It has been indicated that injection of LPS into the lateral ventricle of the rat , s brain attenuates memory retention trail 21 . Researcher has also reported that i.p.…”
Section: Discussionmentioning
confidence: 99%
“…The pharmacological efficacy of Korean ginseng is known to be enhanced by these processes mostly due to the changes in the characteristics of the constituent ginsenosides (Blumenthal 2001). Accumulating evidence also shows that ginsenosides are pharmacological compounds with anti-inflammatory and anti-carcinogenic effects (Kim et al 2013a;Lee et al 2013). By using in vivo inflammatory models, the anti-inflammatory effects of Korean Red Ginseng (KRG) have been reported (Jung et al 2013;Kim et al 2010).…”
Section: Introductionmentioning
confidence: 96%