Ginsenoside Re attenuates 8-OH-DPAT-induced serotonergic behaviors in mice via interactive modulation between <i>PKCδ</i> gene and Nrf2

Shin, Eun‐Joo; Jeong, Ji Hoon; Nguyen, Bao-Trong; Sharma, Naveen; Tran, Cuong Ngoc Kim; Nah, Seung-Yeol; Lee, Yi; Byun, Jae Kyung; Ko, Sung Kwon; Kim, Hyoung‐Chun

doi:10.1080/01480545.2021.2022689

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…GRe ameliorated aging‐associated memory impairments in the absence of GPx‐1 by inactivating oxidative insult, PAFR, NF‐κb, and microgliosis (Shin, Nguyen, et al, 2023). GRe‐mediated anticonvulsive/neuroprotective effects require the attenuation of mitochondrial dysfunction and altered redox status and inactivation of PKCδ (Shin, Jeong, et al, 2023; Tran et al, 2023). The same bioactive constituents of Notoginseng Radix and Ginseng Radix et Rhizoma are presented in the section on Ginseng Radix et Rhizoma .…”

Section: Potential Mechanisms Of Tcm and Its Major Bioactive Constitu...mentioning

confidence: 99%

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Fan,

Liu,

Liu

et al. 2023

Phytotherapy Research

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Ischemic stroke (IS) remains one of the leading causes of death and disability in humans. Unfortunately, none of the treatments effectively provide functional benefits to patients with IS, although many do so by targeting different aspects of the ischemic cascade response. The advantages of traditional Chinese medicine (TCM) in preventing and treating IS are obvious in terms of early treatment and global coordination. The efficacy of TCM and its bioactive constituents has been scientifically proven over the past decades. Based on clinical trials, this article provides a review of commonly used TCM patent medicines and herbal decoctions indicated for IS. In addition, this paper also reviews the mechanisms of bioactive constituents in TCM for the treatment of IS in recent years, both domestically and internationally. A comprehensive review of preclinical and clinical studies will hopefully provide new ideas to address the threat of IS.

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Section: Potential Mechanisms Of Tcm and Its Major Bioactive Constitu...mentioning

confidence: 99%

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Fan,

Liu,

Liu

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

Ginsenoside Re mitigates memory impairments in aged GPx-1 KO mice by inhibiting the interplay between PAFR, NFκB, and microgliosis in the hippocampus

Shin

Nguyen

Sharma

et al. 2023

Food and Chemical Toxicology

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Ginsenoside Re blocks Bay k-8644-induced neurotoxicity via attenuating mitochondrial dysfunction and PKCδ activation in the hippocampus of mice: Involvement of antioxidant potential

Tran

Jeong

Sharma

et al. 2023

Food and Chemical Toxicology

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Ginsenoside Re attenuates 8-OH-DPAT-induced serotonergic behaviors in mice via interactive modulation between PKCδ gene and Nrf2

Cited by 3 publications

References 46 publications

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Ginsenoside Re mitigates memory impairments in aged GPx-1 KO mice by inhibiting the interplay between PAFR, NFκB, and microgliosis in the hippocampus

Ginsenoside Re blocks Bay k-8644-induced neurotoxicity via attenuating mitochondrial dysfunction and PKCδ activation in the hippocampus of mice: Involvement of antioxidant potential

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