Ginsenoside Rb1 increases central nervous system cholinergic metabolism

Benishin, Christina G.

doi:10.1016/0014-2999(90)92768-e

Cited by 27 publications

(32 citation statements)

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“…The present study indicates that Rg1 attenuates memory defi cits through inhibiting AChE activity. But for Rb1, it was reported that Rb1 has no effect on AChE activity in vitro (Benishin et al, 1991), this is consistent with our results. In other words, Rg1 shows a superior effect to Rb1 on inhibiting AChE activity on improving memory in mice with scopolamine-induced amnesia.…”

Section: Discussionsupporting

confidence: 96%

Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine‐induced learning and memory impairment in mice

Wang

Sun

Jia

et al. 2010

Phytotherapy Research

102

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Rg1 and Rb1 are two major active compounds of ginseng that facilitate learning and memory. The present study aimed to compare the nootropic effects of Rg1 and Rb1 in a scopolamine induced dementia mice model. After 6 and 12 mg/kg of Rg1 and Rb1 intraperitoneal administration to mice for 7 days, their effects were assessed using the step-down passive avoidance (SD) and the Morris water maze (MWM) tests, the acetylcholinesterase (AChE) activity, acetylcholine (ACh) content and serotonin (5-HT) level in the hippocampus were analysed after SD and MWM tests. The results showed that Rg1 and Rb1 ameliorated cognition-deficiency in mice with dementia. Rg1 showed stronger effects than Rb1 on escape acquisition in MWM. Both Rg1 and Rb1 increased ACh levels in the hippocampus, but Rg1 inhibited AChE activity while Rb1 had no effect on AChE activity. Both Rg1 and Rb1 inhibited the decrease of 5-HT induced by scopolamine, but Rb1 was more active than the same dose of Rg1. These results demonstrate that multiple administrations of Rg1 and Rb1 are effective in improving memory deficiency induced by scopolamine. Rg1 appears to be more potent than Rb1 in improving acquisition impairment, and the two ginsenosides may act through different mechanisms.

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Section: Discussionsupporting

confidence: 96%

Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine‐induced learning and memory impairment in mice

Wang

Sun

Jia

et al. 2010

Phytotherapy Research

102

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“…There are over 20 kinds of ginsenosides, which are derivatives having the triterpene dammarane structure, and agylcones of the ginsenosides are of 20(S)-protopanaxdiol (Rb1, Rb2, Rc and Rd) and 20(S)-protopanaxtriol (Re, Rf, Rg1 and Rg2) [3]. For their biological functions, ginsenosides Rb1, Rg1 and Re have a preventive effect against memory deficits [6,7], and Rb1 and Rg1 have both stimulatory and inhibitory effect on the CNS [8,9]. These reports imply that most of the ginsenosides have multiple effects on the same target.…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rg1 helps mice resist to disseminated candidiasis by Th1 type differentiation of CD4+ T cell

Lee

2006

International Immunopharmacology

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“…In general, Rb1 and Rg1 are thought to enhance learning and memory by facilitating cholinergic function. For example, Rb1 facilitated acetylcholine (ACh) release and improved passive avoidance learning (Benishin et al, 1991). Rb1 and Rg1 increased the number of ACh receptors and improved inhibitory avoidance learning in anisodine-treated mice (Zhang et al, 1990).…”

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confidence: 99%

Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice

Mook‐Jung

Hong

Boo

et al. 2001

J of Neuroscience Research

129

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We investigated the cognition enhancing effects of ginsenoside Rb1 and Rg1. Mice were trained in a Morris water maze following injection (i.p.) of Rb1 (1 mg/kg) or Rg1 (1 mg/kg) for 4 days. Both Rb1- and Rg1-injected mice showed enhanced spatial learning compared to control animals. The hippocampus, but not the frontal cortex, of treated mice contained higher density of a synaptic marker protein, synaptophysin, compared to control mice. Electrophysiological recordings in hippocampal slices revealed that Rb1 or Rg1 injection did not change the magnitude of paired-pulse facilitation or long-term potentiation. Our results suggest that Rb1 and Rg1 enhance spatial learning ability by increasing hippocampal synaptic density without changing plasticity of individual synapses.

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Ginsenoside Rb1 increases central nervous system cholinergic metabolism

Cited by 27 publications

References 0 publications

Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine‐induced learning and memory impairment in mice

Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine‐induced learning and memory impairment in mice

Ginsenoside Rg1 helps mice resist to disseminated candidiasis by Th1 type differentiation of CD4+ T cell

Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice

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