Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinson's disease

Zhang, Yun-Long; Liu, Yan; Kang, Xin-Pan; Dou, Chunyan; Zhuo, Rengong; Huang, Shuqiong; Li, Peng; Wen, Lei

doi:10.1016/j.neuropharm.2017.12.012

Cited by 46 publications

(53 citation statements)

References 83 publications

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“…Taken together, these findings indicated that ginseng exhibits its neuroprotective properties and improves is could be due to the presence of bioactive compound ginsenosides in ginseng. Several studies have reported on the neuroprotective effect of ginsenosides, particularly ginsenosides Rg1, in various neurodegeneration models [157][158][159][160][161][162][163][164][165][166][167][168][169].…”

Section: Ginseng Ginseng Is a Perennial Herb Belonging To Thementioning

confidence: 99%

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Sairazi

Sirajudeen

2020

Evidence-Based Complementary and Alternative Medicine

130

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In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases.

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Section: Ginseng Ginseng Is a Perennial Herb Belonging To Thementioning

confidence: 99%

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Sairazi

Sirajudeen

2020

Evidence-Based Complementary and Alternative Medicine

130

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“…The ginsenoside Rb1 has been widely assessed for its neuroprotective features [66]. While most experiments used a limited number of doses, several papers reported hormetic-biphasic dose responses for Rb1.…”

Section: Alzheimer's and Parkinson's Diseases And Stroke Modelsmentioning

confidence: 99%

Hormesis and Ginseng: Ginseng Mixtures and Individual Constituents Commonly Display Hormesis Dose Responses, Especially for Neuroprotective Effects

Calabrese

2020

Molecules

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This paper demonstrates that ginseng mixtures and individual ginseng chemical constituents commonly induce hormetic dose responses in numerous biological models for endpoints of biomedical and clinical relevance, typically providing a mechanistic framework. The principal focus of ginseng hormesis-related research has been directed toward enhancing neuroprotection against conditions such as Alzheimer’s and Parkinson’s Diseases, stroke damage, as well as enhancing spinal cord and peripheral neuronal damage repair and reducing pain. Ginseng was also shown to reduce symptoms of diabetes, prevent cardiovascular system damage, protect the kidney from toxicities due to immune suppressant drugs, and prevent corneal damage, amongst other examples. These findings complement similar hormetic-based chemoprotective reports for other widely used dietary-type supplements such as curcumin, ginkgo biloba, and green tea. These findings, which provide further support for the generality of the hormetic dose response in the biomedical literature, have potentially important public health and clinical implications.

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“…Rb1 treatment ameliorated MPTP-induced motor impairment, protected dopaminergic neuron death, and suppressed α-synuclein expression and astrogliosis in mouse. It increased glutamate transporter expression through nuclear translocation of NF-κB, regulated glutamate receptor expression, and promoted synaptic protein expression [ 73 ]. Two major pharmacological effects of ginsenoside Rb1 on cognitive impairment are shown in Figure 2 .…”

Section: Pharmacological Potential Of Active Ginseng Constituents In mentioning

confidence: 99%

Active ginseng components in cognitive impairment: Therapeutic potential and prospects for delivery and clinical study

et al. 2018

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Cognitive impairment is a state that affects thinking, communication, understanding, and memory, and is very common in various neurological disorders. Among many factors, age-related cognitive decline is an important area in mental health research. Research to find therapeutic medications or supplements to treat cognitive deficits and maintain cognitive health has been ongoing. Ginseng and its active components may have played a role in treating chronic disorders. Numerous preclinical studies have confirmed that ginseng and its active components such as ginsenosides, gintonin, and compound K are pharmacologically efficacious in different models of and are linked to cognitive impairment. Among their several roles, they act as an anti-neuroinflammatory and help fight against oxidative stress and modulate the cholinergic signal. These roles may be involved in enhancing cognition and attenuating impairment. There have been some clinical studies on the activity of ginseng in cognitive impairment, but many ginseng species and active compounds remain to be investigated. In addition, new formulations of active ginseng components such as nanoparticles and liposomes could be used for preclinical and clinical models of cognitive impairment. Here, we discuss the therapeutic potential of active ginseng components in cognitive impairment and their chemistry and pharmacokinetics and consider prospects for their delivery and clinical study with respect to cognitive impairment.

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Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinson's disease

Cited by 46 publications

References 83 publications

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Hormesis and Ginseng: Ginseng Mixtures and Individual Constituents Commonly Display Hormesis Dose Responses, Especially for Neuroprotective Effects

Active ginseng components in cognitive impairment: Therapeutic potential and prospects for delivery and clinical study

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