Ginsenoside Rb1, a principal effective ingredient of Panax notoginseng, produces pain antihypersensitivity by spinal microglial dynorphin A expression

Regulation of transcriptome networks that mediate ginsenoside biosynthesis by essential ecological factors

“…Ginsenoside Rb1, a highly valued natural compound, has garnered extensive attention and investigation for its diverse range of biological activities and medicinal properties. This compound plays a pivotal role in various physiological processes, such as safeguarding the cardiovascular system [7][8][9][10], regulating the central nervous system [11][12][13][14][15][16], modulating immune responses [17][18][19][20], enhancing skeletal health [21], promoting metabolism [22], and exhibiting anti-diabetic effects [17]. Notably, ginsenoside Rg1 has been shown to prevent depression-like behaviors and neuronal structural plasticity induced by chronic stress [23].…”

Progress of Ginsenoside Rb1 in neurological disorders

“…Additionally, a study discovered that GsRb1 reduced the amplitude of nerve action potentials to treat cervical spondylosis similar to SCI and heal spinal cord damage ( Lee et al, 2021 ). GsRb1 and its metabolite CK can be used in the clinic as an anti-injury (reduction of mechanical, cold, and thermal nociceptive hypersensitivity) drug to alleviate NP symptoms through the endoplasmic reticulum-mediated expression of estrogen receptor (ER)-α (ER-α) and ER-β expressed in the dorsal horn neurons of the L4-L5 spinal cord ( Lee et al, 2021 ; Shoaib et al, 2023 ), which provides new insight into the future strategy for the diagnosis and treatment of SCI in humans.…”