Ginsenoside 20(S)-protopanaxadiol inhibits triple-negative breast cancer metastasis in vivo by targeting EGFR-mediated MAPK pathway

Peng, Bo; He, Rong; Xu, Qingmei; Yang, Yifei; Hu, Qin; Hou, Hongping; Liu, Xinmin; Lǐ, Jiànróng

doi:10.1016/j.phrs.2019.02.003

Cited by 46 publications

(34 citation statements)

References 47 publications

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“…patients with high expression levels of MAPK and EGFR had a poorer prognosis and lower survival rates than those with low expression, consistent with previous studies (26,27). Moreover, the proliferation of TNBC cells may be inhibited by targeting the MAPK pathway, thus achieving therapeutic effects (17,28,29). Taken together, the results of the present study indicate that MAPK and EGFR play a primary role in TNBC development, and may be considered as independent prognostic indicators and new targets for the treatment of TNBC.…”

Section: Discussionsupporting

confidence: 87%

Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer

et al. 2020

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To investigate the expression and clinical significance of mitogen-activated protein kinase (MAPK) and epidermal growth factor receptor (EGFR) in triple-negative breast cancer (TNBC), a total of 300 TNBC and 120 paired paracancerous tissues were examined. Immunohistochemistry was conducted to determine the expression levels of MAPK and EGFR, and the correlation between MAPK and EGFR expression was evaluated using Cramer's V test. The association between MAPK and EGFR expression, and various clinicopathological variables (such as lymph node metastasis, clinical stage, recurrence and metastasis) was also evaluated, using the χ 2 test. MAPK and EGFR expression levels in TNBC tissues were significantly higher than in the paired paracancerous tissues. Moreover, MAPK expression was associated with that of EGFR in TNBC tissues. The positive expression rates of MAPK and EGFR in patients with lymph node metastasis, advanced clinical stage, tumor recurrence and metastasis were higher than those without. Patients with positive expression of MAPK and EGFR in TNBC tissues had poorer prognoses and lower overall survival times than those without expression. In summary, the expression of MAPK and EGFR is closely associated with tumor invasion and the metastasis of TNBC, and may therefore be used as an indicator of poor prognosis in patients with TNBC.

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Section: Discussionsupporting

confidence: 87%

Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer

et al. 2020

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“…Breast cancer is a common form of malignant tumor in females [1][2][3]. In recent years, more cases of bone metastasis of breast cancer have been seen with an increasing incidence of this malignant tumour tumor [4].…”

Section: Introductionmentioning

confidence: 99%

Graphene-modified CePO4 nanorods effectively treat breast cancer-induced bone metastases and regulate macrophage polarization to improve osteo-inductive ability

Liu

et al. 2021

J Nanobiotechnol

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Background Breast cancer bone metastasis has become one of the most common complications; however, it may cause cancer recurrence and bone nonunion, as well as local bone defects. Methods Herein, In vitro, we verified the effect of bioscaffold materials on cell proliferation and apoptosis through a CCK8 trial, staining of live/dead cells, and flow cytometry. We used immunofluorescence technology and flow cytometry to verify whether bioscaffold materials regulate macrophage polarization, and we used ALP staining, alizarin red staining and PCR to verify whether bioscaffold material promotes bone regeneration. In vivo, we once again studied the effect of bioscaffold materials on tumors by measuring tumor volume in mice, Tunel staining, and caspase-3 immunofluorescence. We also constructed a mouse skull ultimate defect model to verify the effect on bone regeneration. Results Graphene oxide (GO) nanoparticles, hydrated CePO4 nanorods and bioactive chitosan (CS) are combined to form a bioactive multifunctional CePO4/CS/GO scaffold, with characteristics such as photothermal therapy to kill tumors, macrophage polarization to promote blood vessel formation, and induction of bone formation. CePO4/CS/GO scaffold activates the caspase-3 proteasein local tumor cells, thereby lysing the DNA between nucleosomes and causing apoptosis. On the one hand, the as-released Ce3+ ions promote M2 polarization of macrophages, which secretes vascular endothelial growth factor (VEGF) and Arginase-1 (Arg-1), which promotes angiogenesis. On the other hand, the as-released Ce3+ ions also activated the BMP-2/Smad signaling pathway which facilitated bone tissue regeneration. Conclusion The multifunctional CePO4/CS/GO scaffolds may become a promising platform for therapy of breast cancer bone metastases.

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“…Bioactive substances display a number of anticancer features, like repression of cell multiplication, activation of apoptosis and cancer metastasis. Several studies have demonstrated their significant potential to treat the lung cancer or triple‐negative breast cancer (TNBC) via inhibiting the tumour and metastasis 16,17 . The less toxicity of these compounds makes them as promising agents for the treatment of cancer.…”

Section: Introductionmentioning

confidence: 99%

“…12,15 to treat the lung cancer or triple-negative breast cancer (TNBC) via inhibiting the tumour and metastasis. 16,17 The less toxicity of these compounds makes them as promising agents for the treatment of cancer.…”

Section: Introductionmentioning

confidence: 99%

Thidiazuron decreases epithelial‐mesenchymal transition activity through the NF‐kB and PI3K/AKT signalling pathways in breast cancer

Rajendran

Ammar

Al-Saeedi

et al. 2020

J Cellular Molecular Medi

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Ginsenoside 20(S)-protopanaxadiol inhibits triple-negative breast cancer metastasis in vivo by targeting EGFR-mediated MAPK pathway

Cited by 46 publications

References 47 publications

Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer

Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer

Graphene-modified CePO4 nanorods effectively treat breast cancer-induced bone metastases and regulate macrophage polarization to improve osteo-inductive ability

Thidiazuron decreases epithelial‐mesenchymal transition activity through the NF‐kB and PI3K/AKT signalling pathways in breast cancer

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