Ginseng polysaccharides enhanced ginsenoside Rb1 and microbial metabolites exposure through enhancing intestinal absorption and affecting gut microbial metabolism

Shen, Hong; Gao, Xuejiao; Li, Ting; Jing, Wanghui; Han, Bei-Lei; Jia, Yumeng; Hu, Nan; Yan, Zhixiang; Li, Songlin; Yan, Ru

doi:10.1016/j.jep.2018.01.021

Cited by 76 publications

(47 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, polysaccharides play important roles in whole therapeutic effects of herbal medicines. For example, ginseng polysaccharides could improve the absorption of ginsenosides, which are bioactive compounds of ginseng in vivo (Zhou et al, 2016 ; Shen et al, 2018 ). In addition, polysaccharides with different molecular weight can exhibit different bioactivity (Chang et al, 2015 ; Wu et al, 2018 ).…”

Section: Comments On Future Studymentioning

confidence: 99%

Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines

2018

View full text Add to dashboard Cite

As an important source for traditional medical systems such as Ayurvedic medicine and traditional Chinese medicine, herbal medicines have received widespread attentions from all over the world, especially in developing countries. Over the past decade, studies on gut microbiota have generated rich information for understanding how gut microbiota shape the functioning of our body system. In view of the importance of gut microbiota, the researchers engaged in studying herbal medicines have paid more and more attention to gut microbiota and gut microbiota metabolites. Among a variety of gut microbiota metabolites, short-chain fatty acids (SCFAs) have received most attention because of their important role in maintaining the hemostasis of hosts and recovery of diseases. Herbal medicines, as an important resource provider for production of SCFAs, have been demonstrated to be able to modulate gut microbiota composition and regulate SCFAs production. In this mini-review, we summarize current knowledge about SCFAs origination, the role of SCFAs in health and disease, the influence of herbal medicine on SCFAs production and the corresponding mechanisms. At the end of this review, the strategies and suggestions for further research of SCFAs and herbal medicines are also discussed.

show abstract

Section: Comments On Future Studymentioning

confidence: 99%

Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines

2018

View full text Add to dashboard Cite

show abstract

“…Ulcerative colitis is characterized with intestinal microbial dysbiosis which is believed to be one of the factors in the initiation and progression of the disease (Shen et al, ). The disordered intestinal tract condition with enhanced intestinal permeability results in pathologically disrupted epithelial barrier function, inciting an immune response.…”

Section: Resultsmentioning

confidence: 99%

Comparative pharmacokinetics of nine major bioactive components in normal and ulcerative colitis rats after oral administration of Lizhong decoction extracts by UPLC–TQ–MS/MS

Shen

Cui

Jiang

et al. 2019

Biomedical Chromatography

View full text Add to dashboard Cite

Lizhong decoction (LZD), a classic formula, has been used to treat ulcerative colitis (UC) for thousands of years in clinical practice. However, the pharmacokinetic characteristics of its major bioactive components in rats under different physiological and pathological states are not clear. Thus, in this study, a rapid and sensitive analytical method, ultra‐performance liquid chromatography coupled with mass spectrometry (UPLC–MS/MS) method, was developed and applied to simultaneously determine glycyrrhizic acid, liquiritin, isoliquiritin, glycyrrhizin, isoliquiritigenin, 6‐gingerol, ginsenoside Rg1, ginsenoside Rb1 and ginsenoside Re in normal and UC rats after oral administration of LZD extract. A Waters BEH C18 UPLC column was used for chromatographic separation, while acetonitrile and 0.1% formic acid were selected as mobile phase. The linearity of nine analytes was >0.9920. Inter‐ and intra‐day accuracy was ≤ 11.4% and precision was from 1.1 to 12.7%. Additionally, stable and suitable extraction recoveries were also obtained. The established method was validated and found to be specific, accurate and precise for nine analytes. Furthermore, it was successfully applied to the pharmacokinetic investigation of nine major components after oral administration of LZD extracts to normal and model rats, respectively. The results showed that the pharmacokinetic parameters (Cmax, Tmax, AUC0–t, AUC0–∞) in the plasma of UC rats were significantly different from those of normal rats, which could provide a reference for the clinical application of LZD.

show abstract

“…The DGGE results showed that the richness and diversity of the caecal flora decreased after the injection of normal mice with Cy [32]. After the oral administration of TCMs and probiotics, the richness, diversity and evenness of the intestinal microflora of mice improved to different degrees, possibly because some TCM components, such as polysaccharides, can provide nutrition for normal flora and promote the growth of probiotics [33,34]. In addition, the effective TCM components are decomposed and metabolized by enzymes produced by intestinal microorganisms.…”

Section: Resultsmentioning

confidence: 99%

Effects of TCMs andLactobacillusstrains on immunosuppressed mice and bacteriostatic effect onEscherichia coliK88 after fermentation

Sun²,

Yang

et al. 2019

Biotechnology & Biotechnological Equipment

View full text Add to dashboard Cite

The aim of this study was to investigate a novel means of treating piglet diarrhoea caused by enterotoxigenic Escherichia coli (ETEC) strain K88 using traditional Chinese medicine (TCM) fermented by selected probiotic strains. Six types of TCMs were determined to be efficient at inhibiting ETEC growth. In addition, two types of probiotics, Lactobacillus 0111 and 0115, were shown to be the most efficient at inhibiting ETEC. The results of studies with mice indicated that the administration of individual TCMs or probiotic strains increased the growth of mice to a different extent. Specifically, the fermentation of Fructus mume, Galla chinensis and Herba taraxaci by the Lactobacillus 0111 strain enhanced their antibacterial ability compared with traditional Jade screen, possibly due to the presence of a compound producing an absorption peak with a retention time of 19.5 min by HPLC. The fermentation of TCMs by probiotic strain provides a novel approach to relieve the effects of the ETEC strain K88.

show abstract

Ginseng polysaccharides enhanced ginsenoside Rb1 and microbial metabolites exposure through enhancing intestinal absorption and affecting gut microbial metabolism

Cited by 76 publications

References 43 publications

Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines

Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines

Comparative pharmacokinetics of nine major bioactive components in normal and ulcerative colitis rats after oral administration of Lizhong decoction extracts by UPLC–TQ–MS/MS

Effects of TCMs andLactobacillusstrains on immunosuppressed mice and bacteriostatic effect onEscherichia coliK88 after fermentation

Contact Info

Product

Resources

About