Ginseng Is Useful to Enhance Cardiac Contractility in Animals

Lin, Jia‐Wei; Cherng, Yih-Giun; Chen, Li‐Jen; Niu, Ho Shan; Chang, Chih Chung; Niu, Chiang Shan

doi:10.1155/2014/723084

Cited by 8 publications

(9 citation statements)

References 45 publications

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“…Also, rat treated with ginseng (250 or 500 mg/kg) inhibited the myocardial infarction after acute myocardial ischemia reperfusion injury [ 31 ] and isoproterenol-induced cardiac injury in rats [ 32 ]. Moreover, it was mentioned that ginseng (400 mg/kg) may enhance cardiac performance through an increase in the expression of PPAR δ and without altering the heart rate in normal rats [ 33 ]. In the present study, the cardiac performance in diabetic rats was also improved by repeated oral intake of ginseng at 150 mg/kg/day for one week and this used dose is markedly lower than used in previous reports for cardiac diseases [ 7 , 8 , 32 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Merit of Ginseng in the Treatment of Heart Failure in Type 1-Like Diabetic Rats

Tsai

Chan

Chen

et al. 2014

BioMed Research International

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The present study investigated the merit of ginseng in the improvement of heart failure in diabetic rats and the role of peroxisome proliferator-activated receptors δ (PPARδ). We used streptozotocin-induced diabetic rat (STZ-rat) to screen the effects of ginseng on cardiac performance and PPARδ expression. Changes of body weight, water intake, and food intake were compared in three groups of age-matched rats; the normal control (Wistar rats) received vehicle, STZ-rats received vehicle and ginseng-treated STZ-rats. We also determined cardiac performances in addition to blood glucose level in these animals. The protein levels of PPARδ in hearts were identified using Western blotting analysis. In STZ-rats, cardiac performances were decreased but the food intake, water intake, and blood glucose were higher than the vehicle-treated control. After a 7-day treatment of ginseng in STZ-rats, cardiac output was markedly enhanced without changes in diabetic parameters. This treatment with ginseng also increased the PPARδ expression in hearts of STZ-rats. The related signal of cardiac contractility, troponin I phosphorylation, was also raised. Ginseng-induced increasing of cardiac output was reversed by the cotreatment with PPARδ antagonist GSK0660. Thus, we suggest that ginseng could improve heart failure through the increased PPARδ expression in STZ-rats.

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Section: Discussionmentioning

confidence: 99%

Merit of Ginseng in the Treatment of Heart Failure in Type 1-Like Diabetic Rats

Tsai

Chan

Chen

et al. 2014

BioMed Research International

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“…Acute administration of ginseng resulted in depressed cardiac contractile function, as evidenced by reductions in HR and blood pressure that persisted up to 24 h. This acute reduction in cardiac contractility appears to be intrinsic to the myocardium, as spontaneously beating perfused hearts exposed to different concentrations of North American ginseng also demonstrated inhibitory response [ 61 ]. On the contrary, Panax ginseng dramatically increases cardiac contractility in normal rats [ 62 ]. The different in response in contractility may due to the differences in components in ginseng of different origin.…”

Section: Anti-aging Properties Of Ginsengmentioning

confidence: 99%

Ginseng: An Nonnegligible Natural Remedy for Healthy Aging

Yang¹,

Ren²,

Zhang³

et al. 2017

Aging and disease

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Aging is an irreversible physiological process that affects all humans. Numerous theories have been proposed to regarding the process from a Western medicine perspective; however, ancient Chinese medicine practices and theories have increasingly gained attention, particularly ginseng, a grass that has been studied for the anti-aging properties of its active constituents. This review seeks to analyze current data on ginseng and its anti-aging properties. The plant species, characteristics, and active ingredients will be introduced. The main part of this review is focused on ginseng and its active components with regards to their effects on prolonging lifespan, the regulation of multiple organ systems including cardiovascular, nervous, immune, and skin, as well as the anti-oxidant and anti-inflammatory properties. The molecular mechanisms of these properties elucidated via various studies are summarized as further evidence of the anti-aging effects of ginseng.

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“…The beating behaviour affected by ginseng could be explained by the molecular mechanisms. In a previous study [33], data of intracellular calcium level and western blotting analysis showed that both the PPAR δ and troponin I phosphorylation were raised by ginseng in neonatal rat cardiomyocyte. Thus, ginseng could enhance cardiac contractility through increased Peroxisome proliferator‐activated receptor (PPAR δ ) protein in the cardiomyocytes.…”

Section: Resultsmentioning

confidence: 99%

Cardiomyocyte contractile force changes in response to AGRWE detected by AFM

Zhao²,

Wang

et al. 2019

Micro & Nano Letters

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The cardiac contractile force is an important predictor of healthy and cardiovascular diseases. The changes of cardiomyocyte contractile force in response to American ginseng root water extract (AGRWE) detected by atomic force microscope have not been investigated yet. This study examined the effects of AGRWE on single beating cardiomyocytes extracted from a newborn rat. The same cardiomyocytes were incubated with AGRWE at a concentration of 50 μg/ml for about 30 min, and the cardiomyocytes' contractile force increased from 1.74 ± 1.01 to 3.49 ± 1.53 nN. The mean value of the contractile strain calculated was 3.32 ± 1.55% for the cardiomyocyte before the treatment with AGRWE, while for the cardiomyocyte treated with AGRWE it increased to 4.60 ± 1.35%. The results also showed that the beating rate of the same single beating cardiomyocytes was decreased from 34 ± 11 beats/min (control, n = 10) to 20 ± 9 beats/min. In conclusion, the experimental results have shown clearly that the contractile forces and strain of single beating cardiomyocytes treated with AGRWE are significantly higher than the control group, while the heart rate was decreased. It suggests that ginseng agents are promising candidates in improving cardiac functions for treating heart failure.

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Ginseng Is Useful to Enhance Cardiac Contractility in Animals

Cited by 8 publications

References 45 publications

Merit of Ginseng in the Treatment of Heart Failure in Type 1-Like Diabetic Rats

Merit of Ginseng in the Treatment of Heart Failure in Type 1-Like Diabetic Rats

Ginseng: An Nonnegligible Natural Remedy for Healthy Aging

Cardiomyocyte contractile force changes in response to AGRWE detected by AFM

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