Ginseng intestinal metabolite-I (GIM-I) reduces doxorubicin toxicity in the mouse testis

Kang, Jun Won; Lee, Young Jung; No, Kyong Ok; Jung, Eun Yong; Sung, Jong Hwan; Kim, Yun-Bae; Nam, Sang Yoon

doi:10.1016/s0890-6238(02)00021-7

Cited by 72 publications

(53 citation statements)

References 21 publications

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“…On the other hand, amifostine failed to protect germ cells in the testes against this type of cytotoxicity [45]. However, it has been reported that ginseng intestinal metabolite-I, the final intestinal bacterial metabolite of ginseng in humans, has an antioxidant effect, and may be partially protective against doxorubicininduced testicular toxicity [29].…”

Section: Discussionmentioning

confidence: 99%

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Green tea extracts attenuate doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity in mice

Sakai

Sueoka

Tanigaki

et al. 2010

J Assist Reprod Genet

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Purpose The aim of this study was to investigate the protective effect of green tea extracts against doxorubicininduced damage in the mouse testes correlating with telomerase activity. Methods Green tea extracts were administered orally. Doxorubicin was coadministered intraperitoneally. These testes were evaluated histologically and the telomerase activity was analyzed. Additional immunostaining was carried out. Results Both the sperm density and sperm motility were significantly increased in green tea extracts coadministration groups as compared to the doxorubicin-treated groups. By histological analysis, germ cell damage was greatly attenuated by green tea extracts coadministration. Telomerase activity significantly increased in association with the coadministration of green tea extracts as compared to that of doxorubicin-only groups. In all groups, human telomerase reverse transcriptase signals were mainly observed in the spermatocytes and spermatids.Conclusions These findings suggest that green tea extracts exert protective effects against doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity levels.

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Section: Discussionmentioning

confidence: 99%

“…To evaluate quantitatively, thirty seminiferous tubules per group were randomly examined for the calculation of Sertoli cell index (SCI). Based on the fact that Sertoli cells do not disappear even at very high testicular failure, SCI is the ratio of the number of germ cells to the number of Sertoli cells [29].…”

Section: Histopathological Examinationmentioning

confidence: 99%

Green tea extracts attenuate doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity in mice

Sakai

Sueoka

Tanigaki

et al. 2010

J Assist Reprod Genet

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“…There has been a significant difference in demorphism and activities of mice treated with DOX and between those treated with DOX + honey. This difference might refer to the potency of honey to protect or to minimize the deteriorating effects of DOX via reducing free H 2 O 2 radicals [8,9] minimizing lipophosphate (LPO) which destroys the plasma membranes leading to many pathological and cellular changes [12][13][14][15][16]. Daily ingestion of honey therefore could protect body from many toxic effects of DOX or other chemicals.…”

Section: Discussionmentioning

confidence: 99%

“…These free radicals are believed to have a destructive role via provoking cells to produce H 2 O 2 radicals which react with lipids forming lipid peroxides (LPO) which destroy the plasma membranes leading to many pathological and cellular changes in a few body parts, e.g. heart [12], kidneys [13], liver [14,15] and genital organs [16].…”

Section: Introductionmentioning

confidence: 99%

Cytoprotectivity of the natural honey against the toxic effects of Doxorubicin in mice

Ganash¹,

Mujallid²,

Al-Robai³

et al. 2014

ABB

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The protectivity of the natural honey has been assessed against the toxicity of Doxorubicin (DOX) in liver tissues of 106 male Albino mice Mus musculus strain weighing 37 ± 3 gm. The body and liver weights, morphological behavior changes, liver function and pathological effects on liver were recorded. Toxicity study of DOX showed that the LD 50 and LD were 20 and 30 mg/Kg, respectively. Intra-peritoneal (i.p.) injection of DOX induced significant (p ≤ 0.01 -0.001) pathological changes in the health, i.e. general weakness, a few morphological changes associated with bleedings, ulceration of skin, hair loss, dimorphism of limbs and bosselation. Daily ingestion of natural honey for seven weeks has led to significant (p ≤ 0.01 -0.001) improvement of these symptoms which appeared as increases in both body and liver weights in comparison with control animals. The natural honey had enhanced the function of liver in treated animals with DOX + honey and reduced the pathological effects of DOX on the above morphological symptoms as well as in the hepatocytes. It is concluded that the ingestion of natural honey has a protective potency against the toxic effects of DOX.

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“…The beneficial effects of ginseng and its main constituents during chemotherapy are probably related to their ability to minimize the adverse effects of antineoplastic drugs. Recent findings in vivo and in vitro have shown that ginseng partially protects against DOX-induced testicular toxicity (Kang et al, 2002), significantly attenuates the effects of DOX-induced heart failure in rats (You et al, 2005), and reduces cisplatin-induced nephrotoxicity in cultured renal proximal tubular epithelial cells (Baek et al, 2006). In contrast, little is known about the effects of ginseng and its compounds when administered in combination with chemotherapeutic drugs.…”

Section: Antigenotoxic Effects Of Panax Ginseng 949mentioning

confidence: 99%

Protection by Panax ginseng C.A. Meyer against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster

et al. 2008

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Panax ginseng is one of the most widely prescribed herbal medicines for the treatment of cancer, diabetes, chronic inflammation, and neurodegenerative and cardiovascular diseases. Since the use of alternative medicines in combination with conventional therapy may increase the risk of unwanted interactions, we investigated the possible genotoxicity of a water-soluble form of the dry root of P. ginseng (2.5, 5.0 or 10.0 mg/mL) and its ability to protect against the genotoxicity of doxorubicin (DOX; 0.125 mg/mL) by using the Drosophila melanogaster wing somatic mutation and recombination test (SMART) with standard and high-bioactivation crosses of flies. Panax ginseng was not genotoxic at the concentrations tested, whereas DOX-induced genotoxicity in marker-heterozygous flies resulted mainly from mitotic recombination. At low concentrations, P. ginseng had antirecombinogenic activity that was independent of the concentration of extract used. Recombination events may promote cancer, but little is known about the ability of P. ginseng to inhibit such recombination or modulate DNA repair mechanisms.

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Ginseng intestinal metabolite-I (GIM-I) reduces doxorubicin toxicity in the mouse testis

Cited by 72 publications

References 21 publications

Green tea extracts attenuate doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity in mice

Green tea extracts attenuate doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity in mice

Cytoprotectivity of the natural honey against the toxic effects of Doxorubicin in mice

Protection by Panax ginseng C.A. Meyer against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster

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