Ginseng Berry Extract Promotes Maturation of Mouse Dendritic Cells

Zhang, Wei; si-young, cho; Gao, Xiang; Min, Kyung‐Jin; Yu, Qing; Jin, Jun‐O

doi:10.1371/journal.pone.0130926

Cited by 29 publications

(28 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 GB has been reported to possess antioxidation, anti-inflammation, collagen synthesis facilitation, skin wrinkle care, whitening, moisturizing, skin barrier improvement, and atopy alleviation effects. 8 The growing studies of GBs seem to point to their health benefits in skin treatments. Among all the biological effects of GBE on skin, protective effects against photoaging and collagen synthesis are of remarkable importance.…”

Section: Introductionmentioning

confidence: 99%

Ginseng-berry-mediated gold and silver nanoparticle synthesis and evaluation of their in vitro antioxidant, antimicrobial, and cytotoxicity effects on human dermal fibroblast and murine melanoma skin cell lines

Pérez¹,

Mathiyalagan²,

Markus³

et al. 2017

IJN

View full text Add to dashboard Cite

There has been a growing interest in the design of environmentally affable and biocompatible nanoparticles among scientists to find novel and safe biomaterials. Panax ginseng Meyer berries have unique phytochemical profile and exhibit beneficial pharmacological activities such as antihyperglycemic, antiobesity, antiaging, and antioxidant properties. A comprehensive study of the biologically active compounds in ginseng berry extract (GBE) and the ability of ginseng berry (GB) as novel material for the biosynthesis of gold nanoparticles (GBAuNPs) and silver nanoparticles (GBAgNPs) was conducted. In addition, the effects of GBAuNPs and GBAgNPs on skin cell lines for further potential biological applications are highlighted. GBAuNPs and GBAgNPs were synthesized using aqueous GBE as a reducing and capping agent. The synthesized nanoparticles were characterized for their size, morphology, and crystallinity. The nanoparticles were evaluated for antioxidant, anti-tyrosinase, antibacterial, and cytotoxicity activities and for morphological changes in human dermal fibroblast and murine melanoma skin cell lines. The phytochemicals contained in GBE effectively reduced and capped gold and silver ions to form GBAuNPs and GBAgNPs. The optimal synthesis conditions (ie, temperature and v/v % of GBE) and kinetics were investigated. Polysaccharides and phenolic compounds present in GBE were suggested to be responsible for stabilization and functionalization of nanoparticles. GBAuNPs and GBAgNPs showed increased scavenging activity against 2,2-diphenyl-1-picrylhydrazyl free radicals compared to GBE. GBAuNPs and GBAgNPs effectively inhibited mushroom tyrosinase, while GBAgNPs showed antibacterial activity against Escherichia coli and Staphylococcus aureus . In addition, GBAuNPs were nontoxic to human dermal fibroblast and murine melanoma cell lines, and GBAgNPs showed cytotoxic effect on murine melanoma cell lines. The current results evidently suggest that GBAgNPs can act as potential agents for antioxidant, anti-tyrosinase, and antibacterial activities. In addition, GBAuNPs can be further developed into mediators in drug delivery and as antioxidant, anti-tyrosinase, and protective skin agents in cosmetic products. Consequently, the study showed the advantages of using nanotechnology and green chemistry to enhance the natural properties of GBs.

show abstract

Section: Introductionmentioning

confidence: 99%

Ginseng-berry-mediated gold and silver nanoparticle synthesis and evaluation of their in vitro antioxidant, antimicrobial, and cytotoxicity effects on human dermal fibroblast and murine melanoma skin cell lines

Pérez¹,

Mathiyalagan²,

Markus³

et al. 2017

IJN

View full text Add to dashboard Cite

show abstract

“…Anti-cancer activity: Recent studies have reported that the ginseng berry exhibits anti-cancer activity in in vitro [20][21][22][23][24][25] and in vivo [26,27], as well as the ability to attenuate chemotherapy-induced side effects [28,29]; these effects result from the promotion of dendritic cell maturation. Interestingly, the ginseng berry induced a higher degree of co-stimulatory molecule up regulation than the root extract at the same concentrations [30]. These studies indicate that the ginseng berry is an intense tumor therapeutic vaccine adjuvant that can be used in investigations and clinical research.…”

Section: Anti-diabetic Activitymentioning

confidence: 74%

Ginseng Berry and its Biological Effects as a Natural Phytochemical

Kim¹,

Cho²,

Kim³

et al. 2016

Nat Prod Chem Res

View full text Add to dashboard Cite

A recent trial in the development of new medications and immune-modulatory agents is to search for candidates among natural products because they have relatively low toxicities in clinical applications. Ginseng has been used as a traditional medicine in Asia and has demonstrated efficacy against various human diseases, such as viral infectious diseases, diabetes, atherosclerosis, and cancer. Recent studies and clinical cases have enhanced the interest in the potential biological effects of the ginseng berry, an association that appears to be due to the phytochemical content of this fruit. The ginseng berry has various bioactivities, such as anti-diabetic, anti-oxidation, anti-neuro degeneration, anti-inflammation, anti-cancer, and enhancement of sexual function bioactivities. Moreover, syringaresinol, the effective anti-aging component of the ginseng berry, has the ability to stimulate longevity via gene activation. Further molecular and clinical studies are necessary to uncover the numerous bioactive substances in the ginseng berry that contribute to public health.

show abstract

“…Recent studies have reported that the ginseng berry also exhibits anti-cancer activity in in vitro [2, [73][74][75][76][77] and in vivo [2, 78,79], as well as the ability to attenuate chemotherapy-induced side effects [80,81]; these effects result from the promotion of dendrite cell maturation. Interestingly, the ginseng berry induced a higher degree of co-stimulatory molecule up regulation than the root extract at the same concentrations [82]. These studies indicate that the ginseng berry is an intense tumor therapeutic vaccine adjuvant that can be used in investigations and clinical research.…”

Section: Anti-cancer Activitymentioning

confidence: 74%

Ginseng Berry, a Promising Anti-Aging Strategy: Recent Opinions on the Biological Effects of a Traditional Korean Ingredient

Seo¹

2016

JARB

View full text Add to dashboard Cite

Journal of Advanced Research in Biotechnology Open Access Review Article Introduction: Ginseng and the Ginseng berryGinseng (Panax ginseng) is a popular herbal medicine that has been used in Asia for 5,000 years [1]. Ginseng is classified as fresh, white, or red ginseng, depending on the processing method. As a traditional herb, red ginseng is known as an adaptogen that restores and improves normal well-being. The use of this herbal plant has been widespread throughout the world because of its therapeutic effects. The well-known biochemical and pharmacological effects include anti-cancer [2], anti-fatigue [3], and anti-diabetic effects [4], along with promoting the synthesis of DNA, RNA and proteins [5]. The herb is used as a tea, an extract, or raw directly from powdered root [6]. The representative bioactive compounds are widely considered to begin senosides, which are ginseng-specific saponins [7]. Currently, more than 100 naturally occurring saponins of various types and products of enzymatic conversion have been isolated from the roots, stems, leaves, flowers, berries, and seeds of ginseng. The different parts of ginseng contain distinct ginsenoside profiles, and thus, different parts probably possess different pharmacological effects [8].Recently, many health reports have recommended an increase in fruit intake as part of a healthy dietary pattern [9,10]. These reports allow for various forms of fruit, including fresh, frozen, and dried, as well as juices, and recommend fruits such as oranges, apples, bananas, grapes, raisins, and berries. Whereas berries are known as a good source of potassium or fiber, recent studies suggest that berry fruits are a rich source of many phytochemicals that have a broad spectrum of bioactivity and a positive impact on general health. Several berry fruits, including blackberries, blueberries, cranberries, raspberries, and strawberries, have recently received attention as a result of their effects in vitro and their associations with lowered risks for some chronic diseases, which were found in recent observational research [11,12]. As a perennial herb, ginseng develops flowers and fruits that bloom in its third and fourth year. Unlike the widely used ginseng root, the ginseng berry is preserved for planting and has not been used by general populations. A recent study reported that the ginseng leaf and berry have higher levels of ginsenosides than ginseng root, and their pharmacological activities have also been reported [13]. In this review, we will summarize the research on the role of dietary ginseng berries in delaying aging, as well as evidence suggesting positive biological effects to prevent age-related diseases. Ginseng Berry Bioactive Content and CompositionThe bioactive components of ginseng are triterpene glycosides or saponins, which are commonly regarded as ginsenosides. AbstractA recent effort in the development of new medications and immune modulatory agents is to search for candidates among natural products because they have relatively low toxicities in clinica...

show abstract

Ginseng Berry Extract Promotes Maturation of Mouse Dendritic Cells

Cited by 29 publications

References 34 publications

Ginseng-berry-mediated gold and silver nanoparticle synthesis and evaluation of their in vitro antioxidant, antimicrobial, and cytotoxicity effects on human dermal fibroblast and murine melanoma skin cell lines

Ginseng-berry-mediated gold and silver nanoparticle synthesis and evaluation of their in vitro antioxidant, antimicrobial, and cytotoxicity effects on human dermal fibroblast and murine melanoma skin cell lines

Ginseng Berry and its Biological Effects as a Natural Phytochemical

Ginseng Berry, a Promising Anti-Aging Strategy: Recent Opinions on the Biological Effects of a Traditional Korean Ingredient

Contact Info

Product

Resources

About