Ginseng and Diabetes

Xie, Jing‐Tian; Mchendale, Sangeeta; Yuan, Chun‐Su

doi:10.1142/s0192415x05003004

Cited by 151 publications

(95 citation statements)

References 31 publications

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“…7) Because herbal medicines are extracted from raw botanical materials, control of the sources of botanical material is the first step in quality assurance of herbal medicines. 8,9) Recent developments in biological techniques, such as molecular genetic markers, allow for the identification of plant species through the detection of species-specific alleles. Compared to chemical constituents, genomic characters are stable for a certain plant species or population, and can be used as a marker for the discrimination of plant species or populations.…”

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confidence: 99%

Discrimination of Lonicera japonica THUNB. from Different Geographical Origins Using Restriction Fragment Length Polymorphism Analysis

Wang

Ding

et al. 2007

Biological & Pharmaceutical Bulletin

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Lonicera japonica THUNB. (Caprifoliaceae) is commonly used as an anti-inflammatory herbal medicine in China. 1,2) We found that L. japonica produced in Henan and Shandong Provinces has the most potent anti-inflammatory effect.3) The herbs grown in these two provinces are recognized as geo-authentic and possess a higher content of therapeutically effective components in the flowers.4) The ecological factors for the cultivation of geo-authentic L. japonica have been studied.5) We attempted to classify the geo-authentic L. japonica by microscopic and chemical characteristics, but because these factors are not well-established, it was difficult to identify specific criteria to distinguish the geo-and non-authentic varieties of L. japonica. 6)Standardization of herbal products is important for safe and effective use. 7) Because herbal medicines are extracted from raw botanical materials, control of the sources of botanical material is the first step in quality assurance of herbal medicines. 8,9) Recent developments in biological techniques, such as molecular genetic markers, allow for the identification of plant species through the detection of species-specific alleles. Compared to chemical constituents, genomic characters are stable for a certain plant species or population, and can be used as a marker for the discrimination of plant species or populations. 10) Our group has established speciesspecific PCR and PCR-RFLP methods to classify Fritillaria cihhosa and Fritillaria pallidiflora.11,12) However, authentication of the geographic origin of plants is difficult with molecular methods, because distinguishing sites in DNA sequences are hard to find.In the present study, we found that a mutation site in the nuclear ribosomal DNA internal transcribed spacer (nrDNA ITS) region from geo-authentic L. japonica can be recognized by the restriction endonuclease EcoN I. Since the PCR products from geo-authentic L. japonica cannot be digested completely and some PCR products from non-geo-authentic L. japonica can be digested partially, a quantitative PCR-RFLP method to discriminate between the two populations is developed. The cleavage rate of PCR products by EcoN I was determined and correlated remarkably with the geographical origin of L. japonica. This method has been used successfully in distinguishing commercial herbs. (Fig. 1). The flowers of L. hypoglauca (L2002028) were collected in Jiujian, Jiangxi Prov.; L. confuse (L2002031) was collected in Xupu, Hunan Prov.; L. dasystyla (L2002034) was collected in Guilin, Guangxi Prov. Crude drugs of L. japonia were purchased from three different pharmacies in Nanjing, Jiangsu Prov. (L2002046, L2002047, L2002048), Wulong, Chongqing Prov. (L2002049) and Guiyang, Guizhou Prov. (L2002050). Each specimen was morphologically identified by the authors and voucher specimens were deposited in the University Herbarium at the China Pharmaceutical University, Nanjing, China. MATERIALS AND METHODS Plant MaterialsPCR Amplification and Sequence Determination of nrDNA ITS Region Three fresh ...

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confidence: 99%

Discrimination of Lonicera japonica THUNB. from Different Geographical Origins Using Restriction Fragment Length Polymorphism Analysis

Wang

Ding

et al. 2007

Biological & Pharmaceutical Bulletin

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“…The use of this herb has been spread worldwide due to its therapeutic effects. Well-known biochemical and pharmacological effects include anti -aging, anti-diabetic, anti-fatigue, along with promoting the synthesis of DNA, RNA and proteins (Attele et al, 2002;Xie, Mehendale, and Yuan 2005;Christensen 2008;King and Murphy 2010). Studies have also shown that ginseng has beneficial effects on the central nervous system, cardiovascular system, and immune system (Block and Mead, 2003; Cancer prevention and inhibition of tumor growth are among other effects (Shin et al, 2000;Shibata 2001;Wang et al, 2007;King and Murphy, 2010).…”

Section: About Ginsengmentioning

confidence: 99%

Preventive and Therapeutic Roles of Ginseng - Focus on Colon Cancer

Jafari‐Vayghan

Ghadimi²,

Nourazarian³

2014

Asian Pacific Journal of Cancer Prevention

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Colorectal cancer is one of the most prevalent diseases all over the world. Early screening and start of chemotherapy is effective in decreasing mortality. This type of cancer can be controlled to some extent via a healthy diet rich in fruit and vegetables. Ginseng is a plant which has been consumed as a herbal medicine for thousands of years in Asian countries. Several in vitro and in vivo studies have shown that this plant not only reduces the incidence of colorectal cancer, but also improves patient's status by enhancing the effects of chemotherapy drugs. However, further studies are needed to prove this relationship. We briefly review ginseng and its components such as ginsenosides reported anticancer effects and their mechanisms of action. Understanding these relationships may produce insights into chemical and pharmacological approaches for enhancing the chemo preventive effects of ginsenosides and for developing novel anticancer agents.

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“…They have shown that this extract modulates proteins involved in regulating inflammatory pathways and regulate carbohydrate metabolism in human skeletal muscle culture, respectively [73,74]. Panax ginseng has been used to treat diabetes [75]. The previous studies with plants have been performed to obtain potential biomarkers for the pathogenesis of diabetes and following studies were carried out by Cho [76,77] & Cho et al [78,79] to analyse antidiabetic actions of ginsenoside Re.…”

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confidence: 99%