There is a global health concern caused by the COVID-19 pandemic and a need for effective treatments to reduce morbidity and mortality associated with the disease. Various agents have been proposed as potential remedies against COVID-19. The review aims to highlight and compare between different therapeutic modalities for the management of COVID-19. We conducted a search strategy using medical subject headings (MeSH) and included literature reviews, systematic reviews, and relevant updated publications from 2019 up to October 2023. The transmission of the virus occurs through coming into direct contact with a person who is infected or respiratory droplets expelled during coughing and/or sneezing. Precautionary safeguards like isolation, handwashing, maskwearing, and lockdowns have been implemented, but the need for effective treatment remains paramount. Antiviral, antimicrobial, and immunomodulatory agents have been proposed as potential remedies against COVID-19. Managing symptoms may involve administering antipyretics and/or anti-inflammatory medications to alleviate fever and mild pain, as well as providing oxygen therapy for respiratory distress. In extreme situations, the use of mechanical ventilation might become essential. In conclusion, Hydroxychloroquine and remdesivir have displayed promising outcomes in clinical settings. Tocilizumab, an immunomodulatory agent, has shown reduced mortality rates compared to controls. The pairing of bamlanivimab and etesevimab has shown a notable decrease in viral load. Fingolimod, a small molecule modulator, is being studied for its potential to regulate the immune response in severely infected COVID-19 patients. A small clinical trial found that taking pentoxifylline and vitamin C together resulted in the reduction of inflammatory markers levels. COVID-19 vaccination has shown promising protection against infection, reduced hospitalization rates, and lower mortality rates.