Ginseng: a potential cause of long QT

Torbey, Estelle; Rafeh, Nidal Abi; Khoueiry, Georges; Kowalski, Marcin; Bekheit, Soad

doi:10.1016/j.jelectrocard.2010.08.007

Cited by 24 publications

(8 citation statements)

References 5 publications

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“…Upon stopping Ginseng consumption, the patient had no subsequent events. Yet, it is not proven whether a higher dose of Ginseng or a synergistic effect of caffeine could further prolong QT leading to malignant dysrhythmias (Torbey et al, 2011). Additionally, an AF with slow ventricular rate developed after taking AG for 1-week in an 83-year old woman with chronic renal disease (Liao et al, 2010).…”

Section: Safety Toxicity and Side Effects Of Ginsengmentioning

confidence: 99%

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

et al. 2020

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Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing prevalence. They remain the leading causes of morbidity and mortality worldwide. The use of medicinal herbs continues to be an alternative treatment approach for several diseases including CVDs. Currently, there is an unprecedented drive for the use of herbal preparations in modern medicinal systems. This drive is powered by several aspects, prime among which are their cost-effective therapeutic promise compared to standard modern therapies and the general belief that they are safe. Nonetheless, the claimed safety of herbal preparations yet remains to be properly tested. Consequently, public awareness should be raised regarding medicinal herbs safety, toxicity, potentially lifethreatening adverse effects, and possible herb-drug interactions. Over the years, laboratory data have shown that medicinal herbs may have therapeutic value in CVDs as they can interfere with several CVD risk factors. Accordingly, there have been many attempts to move studies on medicinal herbs from the bench to the bedside, in order to effectively employ herbs in CVD treatments. In this review, we introduce CVDs and their risk factors. Then we overview the use of herbs for disease treatment in general and CVDs in particular. Further, data on the ethnopharmacological therapeutic potentials and medicinal properties against CVDs of four widely used plants, namely Ginseng, Ginkgo biloba, Ganoderma lucidum, and Gynostemma pentaphyllum, are gathered and reviewed. In particular, the employment of these four plants in the context of CVDs, such as myocardial infarction, hypertension, peripheral vascular diseases, coronary heart disease, cardiomyopathies, and dyslipidemias has been reviewed, analyzed, and critically discussed. We also endeavor to document the recent studies aimed to dissect the cellular and molecular cardio-protective mechanisms of the four plants, using recently reported in vitro and in vivo studies. Finally, we reviewed and reported the results of the

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Section: Safety Toxicity and Side Effects Of Ginsengmentioning

confidence: 99%

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

et al. 2020

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“…There are a variety of cardiovascular changes seen in patients taking EDs, with the most common being arrhythmias. Other cardiovascular changes (Table 1) associated with EDs are coronary vasospasm [29], ST elevation [30], prolonged QT interval [31], aortic aneurysm dissection [32], cardiac arrest [33], cardiomyopathy [34], and acute coronary thrombosis [35]. …”

Section: Reviewmentioning

confidence: 99%

“…On arrival to the hospital, the initial EKG showed a normal sinus rhythm with anteroseptal ST elevation and reciprocal inferior ST depression. Israelit, et al describes a case of a young male who was brought to the hospital from a night club with crushing chest pain after drinking 20 cans of EDs [31]. On arrival to the hospital, the EKG showed widespread ST segment elevation.…”

Section: Reviewmentioning

confidence: 99%

Energy Drinks and the Risk of Cardiovascular Disease: A Review of Current Literature

Mangi¹,

Rehman²,

Rafique³

2017

Cureus

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Energy drinks (EDs) are commonly used as a dietary supplement by young adolescents and adults. They are often used as a source of energy in order to enhance physical and mental performance. EDs contain a variety of substances, but caffeine is the main component. Safety has been the biggest concern associated with consuming EDs. Case reports, observational studies, and meta-analyses have been done in order to determine the effects of EDs on cardiovascular changes. The detrimental effects of EDs are cardiac arrhythmias, myocardial infarction, prolonged QT interval, aortic dissection, and death. In this article, we review case reports, observational studies, and meta-analyses of EDs and the risk of cardiovascular events and mortality. We also review active ingredients, pharmacokinetics, and the mechanism of action of EDs.

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“…However, the observed effects are not seemed to be clinically relevant [36] . Another case was reported that a 43-yr-old healthy woman patient without cardiovascular risk factors who developed prolonged QT with subsequent torsades de pointes during periods in which she was abusing P. ginseng on the daily basis for 6 mo [37] . In addition, an atrial fibrillation (AF) with slow ventricular rate developed after taking Asian ginseng for 1 wk in 83-yr-old woman with old chronic renal disease [38] .…”

Section: Cardiovascular and Renal Toxicitymentioning

confidence: 99%

Review of cases of patient risk associated with ginseng abuse and misuse

Paik

Lee

2015

Journal of Ginseng Research

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Ginseng has long been used as a functional food or therapeutic supplement and it is empirically known to be safe and nontoxic. During recent decades, a number of in vitro and in vivo experiments, as well as human studies have been conducted to prove the safety of various types of ginseng samples and their components. Clinical trials, case reports, and in vitro and in vivo research articles addressing the safety, toxicity, and other adverse events of ginseng application were selected and reviewed. Patient risks associated with ginseng abuse and misuse such as affective disorder, allergy, cardiovascular and renal toxicity, genital organ bleeding, gynecomastia, hepatotoxicity, hypertension, reproductive toxicity, and anticoagulant-ginseng interaction were reviewed and summarized. There are some cases of patient risk associated with ginseng abuse and misuse depending on patients' conditions although further investigation in more cases is required to clarify these issues.

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Ginseng: a potential cause of long QT

Cited by 24 publications

References 5 publications

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

Energy Drinks and the Risk of Cardiovascular Disease: A Review of Current Literature

Review of cases of patient risk associated with ginseng abuse and misuse

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