Ginnalin B induces differentiation markers and modulates the proliferation/differentiation balance via the upregulation of NOTCH1 in human epidermal keratinocytes

Kato, Atsushi; Koyama, Junna; Shinzawa, Kenta; Imaeda, Shuki; Adachi, Isao; Nash, Robert J.; Fleet, George W. J.; Shintani, Megumi; Takeuchi, Chihiro; Ishikawa, Fumihiro

doi:10.1016/j.bmc.2019.04.008

Cited by 7 publications

(2 citation statements)

References 34 publications

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“…This regulatory role may contribute to the maintenance of epidermal homeostasis, which is particularly important for skin health and repair. [30] Sedoheptulose kinase regulates cellular carbohydrate metabolism by supplying sedoheptulose 7-phosphate, which promotes the production of nicotinamide adenine dinucleotide phosphate (NADPH), the reducing power used for biosynthesis, and antioxidants. [31] These results demonstrate that radiation causes severe DNA damage to cells, resulting in extensive accumulation of senescent cells.…”

Section: Ability Of Hydrogels To Resist Radiation-induced Cell Senesc...mentioning

confidence: 99%

Glucopeptide Superstructure Hydrogel Promotes Surgical Wound Healing Following Neoadjuvant Radiotherapy by Producing NO and Anticellular Senescence

Wang,

Mu,

Cai

et al. 2024

Adv Healthcare Materials

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Neoadjuvant radiotherapy (NAC), a preoperative intervention regimen for reducing the stage of primary tumors and surgical margins, has gained increasing attention in the past decade. However, radiation‐induced skin damage during neoadjuvant radiotherapy exacerbates surgical injury, remarkably increasing the risk of refractory wounds and compromising the therapeutic effects. Radiation impedes wound healing by increasing the production of reactive oxygen species (ROS) and inducing cell apoptosis and senescence. In this study, we prepared a self‐assembling peptide (R‐peptide) and hyaluronic acid (HA)‐based and cordycepin (Cor)‐loaded superstructure hydrogel (CHRgel) for surgical incision healing after neoadjuvant radiotherapy. Results showed that (i) R‐peptide co‐assembled with HA to form biomimetic fiber bundle microstructure, in which R‐peptide drives the assembly of single fiber through π‐π stacking and other forces and HA, as a single fiber adhesive, facilitates bunching through electrostatic interactions. (ii) The biomimetic superstructure contributes to the adhesion and proliferation of cells in the surgical wound. (iii) Aldehyde‐modified HA provides dynamic covalent binding sites for cordycepin to achieve responsive release, inhibiting radiation‐induced cellular senescence. (iv) Arginine in the peptides provides antioxidant capacity and a substrate for the endogenous production of nitric oxide (NO) to promote wound healing and angiogenesis of surgical wounds after neoadjuvant radiotherapy.This article is protected by copyright. All rights reserved

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Section: Ability Of Hydrogels To Resist Radiation-induced Cell Senesc...mentioning

confidence: 99%

Glucopeptide Superstructure Hydrogel Promotes Surgical Wound Healing Following Neoadjuvant Radiotherapy by Producing NO and Anticellular Senescence

Wang,

Mu,

Cai

et al. 2024

Adv Healthcare Materials

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“…These polyphenols were shown to exhibit different bioactivities such as α-glucosidase inhibition and antioxidant activity. It is noteworthy that different numbers, positions, and types of the phenol units on the 1,5-AG core display non-identical bioactivities [32,33,34,35,36].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Comparative Structure–Activity Study of Carbohydrate-Based Phenolic Compounds as α-Glucosidase Inhibitors and Antioxidants

et al. 2019

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Twenty-one natural and unnatural phenolic compounds containing a carbohydrate moiety were synthesized and their structure–activity relationship (SAR) was evaluated for α-glucosidase inhibition and antioxidative activity. Varying the position of the galloyl unit on the 1,5-anhydro-d-glucitol (1,5-AG) core resulted in changes in the α-glucosidase inhibitory activity and notably, particularly strong activity was demonstrated when the galloyl unit was present at the C-2 position. Furthermore, increasing the number of the galloyl units significantly affected the α-glucosidase inhibition, and 2,3,4,6-tetra-galloyl-1,5-AG (54) and 2,3,4,6-tetra-galloyl-d-glucopyranose (61) exhibited excellent activities, which were more than 13-fold higher than the α-glucosidase inhibitory activity of acertannin (37). Moreover, a comparative structure-activity study suggested that a hemiacetal hydroxyl functionality in the carbohydrate core and a biaryl bond of the 4,6-O-hexahydroxydiphenoyl (HHDP) group, which are components of ellagitannins including tellimagrandin I, are not necessary for the α-glucosidase inhibitory activity. Lastly, the antioxidant activity increased proportionally with the number of galloyl units.

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Inhibitory effects of skin permeable glucitol-core containing gallotannins from red maple leaves on elastase and their protective effects on human keratinocytes

Liu

Kirk

et al. 2020

Journal of Functional Foods

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Ginnalin B induces differentiation markers and modulates the proliferation/differentiation balance via the upregulation of NOTCH1 in human epidermal keratinocytes

Cited by 7 publications

References 34 publications

Glucopeptide Superstructure Hydrogel Promotes Surgical Wound Healing Following Neoadjuvant Radiotherapy by Producing NO and Anticellular Senescence

Glucopeptide Superstructure Hydrogel Promotes Surgical Wound Healing Following Neoadjuvant Radiotherapy by Producing NO and Anticellular Senescence

Synthesis and Comparative Structure–Activity Study of Carbohydrate-Based Phenolic Compounds as α-Glucosidase Inhibitors and Antioxidants

Inhibitory effects of skin permeable glucitol-core containing gallotannins from red maple leaves on elastase and their protective effects on human keratinocytes

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