Ginkgo biloba for tinnitus

Sereda, Magdalena; Xia, Jun; Scutt, Polly; Hilton, Malcolm P; Refaie, Amr El; Hoare, Derek J.

doi:10.1002/14651858.cd013514.pub2

Cited by 15 publications

(3 citation statements)

References 140 publications

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“…Overall, these results provide clinical evidence for antioxidant molecules in tinnitus that should not be ignored. The dietary supplement studied contains Ginko biloba, the effectiveness of which on tinnitus is still uncertain, as concluded by the latest Cochrane review [33]. It should be noted that the poor quality of the 12 RCTs included in this systematic review meant that no further conclusions could be drawn.…”

Section: Discussionmentioning

confidence: 98%

AUDISTIM® Day/Night Alleviates Tinnitus-Related Handicap in Patients with Chronic Tinnitus: A Double-Blind Randomized Placebo-Controlled Trial

PORTMANN,

ESTEVE-FRAYSSE,

FRACHET

et al. 2024

Preprint

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The aim of this study is to evaluate the efficacy of taking a daily supplement based on active compounds (AUDISTIM® Day Night: A D/N) in alleviating tinnitus-related disability, as suggested by previous real-life studies. This double-blind randomized placebo-controlled study was conducted in adult with mild to severe tinnitus receiving a 3 month-supplementation. Tinnitus-related handicap (THI), psychological stress (MSP-9) and sleep quality (PSQI) were assessed at baseline and during intervention, perceived impression of tinnitus improvement at the end of the follow-up. The full set analysis included 114 patients (59 A D/N, 55 placebo) aged 53.8±11.4 years, 58% women, with fluctuating (45%) or permanent (55%) tinnitus from 9.3±9.4 years. A D/N supplementation led to greater changes in THI (-13.2±16.0 vs -6.2±14.4, p=0.0158, Cohen’s d=0.44) at 3 months, especially with continuous tinnitus (-15.0±16.3 vs -4.6±12.8, p=0.0065), and, to a lesser extent, at 1 month (-9.8±13.1 for A vs -4.3±12.1, p=0.0213). PSQI significantly improved over time in both groups, MSP-9 only with A D/N. In lines with previous observational studies, both clinical (THI score &gt; 7 pts) and statistical (vs. placebo) improvement, more pronounced in permanent tinnitus, demonstrate the effectiveness of the combination of active compounds and support its use in the management of mild to severe tinnitus.

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Section: Discussionmentioning

confidence: 98%

AUDISTIM® Day/Night Alleviates Tinnitus-Related Handicap in Patients with Chronic Tinnitus: A Double-Blind Randomized Placebo-Controlled Trial

PORTMANN,

ESTEVE-FRAYSSE,

FRACHET

et al. 2024

Preprint

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“… Polanski et al (2016) studied in a randomized, double-blinded, placebo-controlled trial 58 elderly subjects with tinnitus and associated sensorineural hearing loss treated with G. biloba dry extract (120 mg/day) and several other antioxidants and did not find any benefit from the treatment. In a recent Cochrane Database review of 12 studies with 1915 participants ( Sereda et al, 2022 ), the authors concluded that there is uncertainty about the benefits and harms of G. biloba for the treatment of tinnitus when compared to placebo.…”

Section: Discussionmentioning

confidence: 99%

The effect of MemoVigor 2 on recent-onset idiopathic tinnitus: a randomized double-blind placebo-controlled clinical trial

Balatsouras,

Papitsi,

Koukoutsis

et al. 2024

Front. Pharmacol.

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Background: Tinnitus is a common symptom associated with the conscious perception of sound in the absence of a corresponding external or internal sound source, which can severely impact quality of life. Because of the current limited understanding of the precise pathophysiological mechanism of idiopathic tinnitus, no curable treatment has been attained yet. A food supplement trading as MemoVigor 2, which contains a combination of therapeutic ingredients with mainly antioxidant activity, has been used in the treatment of tinnitus. The objective of our study was to evaluate the effectiveness of MemoVigor 2 in the treatment of recent-onset idiopathic tinnitus.Methods: In a prospective single-centre randomized, double-blind, placebo-controlled clinical trial we studied 204 patients with idiopathic tinnitus divided into two groups: 104 patients who received MemoVigor 2 and 100 patients treated with placebo. To evaluate changes in tinnitus we used (1) audiometry/tympanometry; (2) specific measures of tinnitus perception, including tinnitus pitch, loudness at tinnitus pitch, loudness at 1 kHz, minimum masking level, and residual inhibition; (3) questionnaires of tinnitus handicap inventory, mini tinnitus questionnaire and patients’ global impression of change. All patients underwent this test battery at the beginning of the study and in a repeat post-3-month session.Results: All tinnitus measures, including pitch, loudness, minimum masking level and residual inhibition improved significantly in the intervention group. Most of these measures improved in the placebo group too, but in a lesser degree. All questionnaire scores diminished significantly in both groups, but the degree of decrease was greater in the intervention group. The participants’ tinnitus outcome reported after treatment using the patients’ global impression of change score differed significantly between the two groups, with greater improvement observed in the intervention group.Conclusion: We found that the use of MemoVigor 2 improved recent-onset tinnitus, as proved by a set of tests performed for its evaluation, including audiometric measures, specific measures of tinnitus perception and tinnitus questionnaires. Tinnitus in the placebo group improved too, but to a lesser degree.Clinical Trial Registration: isrctn.com, Identifier ISRCTN16025480

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“…G. biloba studies in the treatment of tinnitus are listed in Table 1 . Though G. biloba extract has been investigated for the treatment of tinnitus in a number of clinical studies, including RCTs, its efficacy remains inconclusive or questionable according to recent meta-analyses ( Mahmoudian-Sani et al, 2017 ; Kramer and Ortigoza, 2018 ; Spiegel et al, 2018 ; Sereda et al, 2022 ). An early randomized study of 259 patients with tinnitus of less than 1 year duration showed that G. biloba extract ( Meyer, 1986 ) reduced the severity of tinnitus in 70% of the patients.…”

Section: Introductionmentioning

confidence: 99%

Herbal medicines in the treatment of tinnitus: An updated review

Hu²,

Wang³

et al. 2023

Front. Pharmacol.

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Tinnitus is perception of sound in the absence of an apparent external acoustic stimulus. The condition is prevalent in adults, especially the elderly (≥65 years), and may be associated with cognitive function decline and significantly impacts on the quality of life, heralding difficulties in managing this challenging disorder. Interventions for tinnitus have been varied. However, drugs have not yet been approved for the treatment of tinnitus and there is no pharmacotherapy recommended by existing guidelines. Still, herbal medicines are used for the treatment of tinnitus in many countries, especially Gingko (G.) biloba. In the current updated literature review, we evaluated the efficacy of herbal medicines in the treatment of tinnitus by reviewing the evidence of relevant randomized controlled trials. The authors also highlight some of the issues in clinical trials of herbal medicines given that currently available evidence on herbal medicines for tinnitus is overall of insufficient quality and the conclusions from existing trials are conflicting. Nevertheless, there is a clear and urgent need for safe and effective pharmacotherapy of tinnitus.

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Ginkgo biloba for tinnitus

Cited by 15 publications

References 140 publications

AUDISTIM® Day/Night Alleviates Tinnitus-Related Handicap in Patients with Chronic Tinnitus: A Double-Blind Randomized Placebo-Controlled Trial

AUDISTIM® Day/Night Alleviates Tinnitus-Related Handicap in Patients with Chronic Tinnitus: A Double-Blind Randomized Placebo-Controlled Trial

The effect of MemoVigor 2 on recent-onset idiopathic tinnitus: a randomized double-blind placebo-controlled clinical trial

Herbal medicines in the treatment of tinnitus: An updated review

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