Ginkgo biloba for tinnitus

Hilton, Malcolm P; Zimmermann, Eleanor; Hunt, William

doi:10.1002/14651858.cd003852.pub3

Cited by 89 publications

(60 citation statements)

References 58 publications

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“…While studies in humans with different Ginkgo biloba extracts so far failed to show any reliable effect on tinnitus perception when given after its development [34, 35], we here tested the effectiveness of a prophylactic treatment with EGb 761 in the context of NIHL and tinnitus development in this animal model. We describe the effects of the EGb 761 extract on the behavioral level (acoustic startle response (ASR) audiometry), the auditory brainstem level (electrophysiological recordings of auditory brainstem responses (ABR)), and the central level (electrophysiological recording of local field potentials (LFP) and single and multiunit responses in auditory cortex (AC)).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects ofGinkgo bilobaExtract EGb 761 against Noise Trauma-Induced Hearing Loss and Tinnitus Development

et al. 2014

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Noise-induced hearing loss (NIHL) and resulting comorbidities like subjective tinnitus are common diseases in modern societies. A substance shown to be effective against NIHL in an animal model is the Ginkgo biloba extract EGb 761. Further effects of the extract on the cellular and systemic levels of the nervous system make it a promising candidate not only for protection against NIHL but also for its secondary comorbidities like tinnitus. Following an earlier study we here tested the potential effectiveness of prophylactic EGb 761 treatment against NIHL and tinnitus development in the Mongolian gerbil. We monitored the effects of EGb 761 and noise trauma-induced changes on signal processing within the auditory system by means of behavioral and electrophysiological approaches. We found significantly reduced NIHL and tinnitus development upon EGb 761 application, compared to vehicle treated animals. These protective effects of EGb 761 were correlated with changes in auditory processing, both at peripheral and central levels. We propose a model with two main effects of EGb 761 on auditory processing, first, an increase of auditory brainstem activity leading to an increased thalamic input to the primary auditory cortex (AI) and second, an asymmetric effect on lateral inhibition in AI.

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Section: Introductionmentioning

confidence: 99%

Protective Effects ofGinkgo bilobaExtract EGb 761 against Noise Trauma-Induced Hearing Loss and Tinnitus Development

et al. 2014

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“…None found a significant difference (e.g. improvement in tinnitus, 13.6% vs. 12.4%; loudness changed from 42.3dB to 39.0dB vs. 44.1dB to 45.1dB; mean difference in THI between groups –2.5, 95% CI –10.5 to +5.1) 30. The most commonly reported unwanted effect of ginkgo biloba was mild gastrointestinal disturbance (e.g.…”

Section: Drug Treatmentmentioning

confidence: 90%

“…It is thought that ginkgo biloba may promote increased blood flow and alter neurone metabolism 30. There is at least one product with a Traditional Herbal Registration (http://www.mhra.gov.uk/home/groups/par/documents/websiteresources/con051911.pdf).…”

Section: Drug Treatmentmentioning

confidence: 99%

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Tinnitus

2013

DTB

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Around 10% of people experience subjective tinnitus (the perception of sound, only audible to the patient, in the absence of an external auditory stimulus).(1-3) It may be associated with hearing loss, anxiety, depression, sleep disturbance, concentration problems or reduced quality of life; for around 0.5% it is extremely disturbing.(1-4) Risk factors include aging, significant noise exposure, drug therapy (e.g. aminoglycosides, NSAIDs, diuretics), or disorders of the outer, middle or inner ear or auditory nerve (e.g. ear wax, infections, vestibular schwannoma, otosclerosis).(1,2,4) It may be due to excessive spontaneous activity in the auditory system and brain; if the signal (normally suppressed by the subconscious) becomes noticed it becomes more intrusive and annoying in a vicious cycle.(5) Here, we discuss symptomatic drug and non-drug treatments for subjective tinnitus in adults. We do not cover treatment of underlying causes of tinnitus.

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“…A crossover design was used with Ginkgo biloba , since G biloba has been widely promoted as an effective tinnitus treatment. However, multiple, large, well controlled, double-blind, placebo-controlled clinical studies have found that G biloba is no more effective than placebo in alleviating tinnitus 4 11 12…”

Section: Introductionmentioning

confidence: 99%