Ginkgo biloba does not benefit patients with tinnitus: a randomized placebo-controlled double-blind trial and meta-analysis of randomized trials

Rejali, Darius; Sivakumar, Aditi; Balaji, Natarajan

doi:10.1111/j.1365-2273.2004.00814.x

Cited by 83 publications

(54 citation statements)

References 30 publications

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“…However, in some studies and clinical trials it has been stated that this herb has no beneficial effect in comparison with placebo in the treatment of tinnitus (Table 2). There are many studies on the effects of Ginkgo biloba in the treatment of patients with tinnitus that most of the findings of these studies are in contrast with each other; on the one hand, some of the studies reported that Ginkgo biloba is effective in the treatment of tinnitus effective [48][49][50][51][52][53] and on the other hand other studies referred to it as ineffective herbal medicine 28,[54][55][56][57] . The results of a systematic review showed that Ginkgo biloba is little/less effective in the treatment of tinnitus.…”

Section: Resultsmentioning

confidence: 61%

Ginkgo biloba in the treatment of tinnitus: An updated literature review

Mahmoudian-Sani¹,

Hashemzadeh‐Chaleshtori²,

Asadi-Samani³

et al. 2017

The International Tinnitus Journal

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Introduction: Tinnitus is one of the common diseases of the ear that is associated with numerous physical and mental disorders. One of the known mechanisms in the tinnitus area with unknown reason is oxidative events. Based on the prevalence and economic costs and physical-psychological side effects caused by tinnitus and the importance of finding a suitable solution for its prevention and treatment, the need for further studies becomes more obvious in this context. This review article aimed to review studies on the effectiveness of Ginkgo biloba as a medicinal plant on patients with tinnitus. Evidence Acquisitions: Google Scholar, Directory of Open Access Journals (DOAJ), PubMed, LISTA (EBSCO) and Web of Science have been searched. Results: There are many studies on the therapeutic effect of Ginkgo biloba on patients with tinnitus. Most findings are in contrast with each other so that some of studies reported that Ginkgo biloba is effective in the treatment of tinnitus and other studies referred to it as ineffective herbal medicine. Generally, according to the previous studies and the present study, it can mention that the Ginkgo biloba may somewhat improve tinnitus. Conclusion: Since tinnitus is multifactorial, it is recommended to evaluate patients individually based on the cause of tinnitus, treatment formulas, and different doses of Ginkgo biloba at the more extensive level in future studies.

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Section: Resultsmentioning

confidence: 61%

Ginkgo biloba in the treatment of tinnitus: An updated literature review

Mahmoudian-Sani¹,

Hashemzadeh‐Chaleshtori²,

Asadi-Samani³

et al. 2017

The International Tinnitus Journal

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“…De acordo com os resultados dos ensaios clínicos randomizados, duplos-cegos e controlados, esses medicamentos são efi cazes no tratamento da claudicação intermitente (Pittler & Ernst, 2000;Jacoby& Mohler, 2004) e da insufi ciência cerebral (doença caracterizada por sintomas típicos, tais como difi culdades de concentração e memória, confusão, indisposição, cansaço, redução da performance física, ansiedade, tontura, zumbido e cefaléia) (Gerhardt et al, 1990;Kleijnen & Knipschild, 1992;Hopfenmüller, 1994), podendo constituir uma alternativa terapêutica para o tratamento de demências do tipo Alzheimer e multi-infarto (Oken et al, 1998;Rogers et al, 1998;Wettstein, 2000;Le Bars et al, 2002;Schulz, 2003) e do zumbido (Ernst & Stevinson, 1999;Drew & Davies, 2001;Morgenstern & Biermann, 2002;Rejali et al, 2004;Smith et al, 2005). Os constituintes químicos considerados ativos do ginkgo são os fl avonóides (glicosídeos de quercetina, canferol e isoramnetina) e as lactonas terpênicas (ginkgolídeos e bilobalídeo) (DeFeudis, 1998).…”

Section: Ginkgounclassified

Interações entre fármacos e medicamentos fitoterápicos à base de ginkgo ou ginseng

Alexandre¹,

Bagatini²,

Simões³

2008

Rev. bras. farmacogn.

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RESUMO:Os medicamentos fi toterápicos são amplamente utilizados, principalmente, pelos portadores de doenças crônicas e em associações medicamentosas com diversos fármacos. As possíveis interações entre eles estão sendo muito estudadas, pois podem alterar os perfi s de efi cácia e segurança de muitos fármacos. Nesta revisão, as informações foram localizadas, avaliadas e sistematizadas e contêm as principais interações entre fármacos e medicamentos fi toterápicos elaborados com ginkgo ou ginseng. Verifi cou-se que os medicamentos fi toterápicos elaborados com tais plantas podem interferir na farmacocinética e/ou farmacodinâmica de diversos fármacos, podendo provocar conseqüências graves aos pacientes. O ginkgo pode interferir com anticoagulantes orais, antiplaquetários e com fármacos metabolizados pelo sistema P450-CYP3A4. O ginseng pode interagir com antidepressivos inibidores da monoamino oxidase, anticoagulantes orais, anti-hipertensivos, e contraceptivos à base de estrogênios. Além disso, não é recomendada a administração concomitante de ginkgo ou ginseng com antineoplásicos. Nesse sentido, o uso concomitante de medicamentos fi toterápicos à base de ginkgo ou ginseng com outros fármacos deve ser adequadamente monitorado. Unitermos: Ginkgo biloba, Panax ginseng, ginkgo, ginseng, interações medicamentosas.ABSTRACT: "Interactions between drugs and ginkgo or ginseng herbal medicines". Herbal medicines are widely used especially by patients with chronic diseases, often administered concomitantly with synthetic drugs, raising the potential of pharmacokinetic and pharmacodynamic drug-herb interactions. From the last years, there is an increasing interest in this subject refl ected by the great number of documented case reports, in vivo studies, and also clinical trials evaluating drug-herb interactions. The aim of this paper was to review the literature in order to identify reported interactions between ginkgo or ginseng herbal medicines and drugs as well as to evaluate and summarize these information. Interactions between ginkgo or ginseng herbal medicines and drugs can occur and may lead to serious consequences. Ginkgo has the potential to cause signifi cant interactions with anticoagulant and antiplatelet drugs, and also with drugs metabolized by the cytochrome P450 enzyme system, especially by CYP3A4. Ginseng has the potential to cause signifi cant interactions with monoamine oxidase inhibitors, warfarin, antihypertensive agents and estrogens. Additionally, both should be avoided with anticancer drugs. Based on these data and regarding patient's safety, the concomitant use of herbal medicines and drugs has to be properly surveyed by physicians and/or other health care professionals.Keywords: Ginkgo biloba, Panax ginseng, ginkgo, ginseng, drug-herb interactions. INTRODUÇÃOA utilização de plantas medicinais e medicamentos fi toterápicos para a recuperação da saúde é uma prática generalizada, sendo o resultado do acúmulo secular de conhecimentos empíricos sobre a ação dos vegetais por diversos grupos étnicos (Simõe...

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“…Extracts of the Ginkgo biloba tree have been claimed by some to alleviate tinnitus and this form of treatment is used widely in Europe (e.g., Ernst and Stevinson, 1999;Schneider et al, 2000). However, other researchers and clinicians dispute this and argue that any beneficial effect is a placebo phenomenon (e.g., Drew and Davies, 2001;Rejai et al, 2004). The aim of this review is to critically evaluate the claims that Ginkgo biloba extracts have clinical efficacy in the treatment of tinnitus.…”

Section: Introductionmentioning

confidence: 96%