Gingival Mucinous Adenocarcinoma of a Minor Salivary Gland

Seoane, Juan; Varela‐Centelles, Pablo; López-Niño, Javier; Vázquez, Inés; Abdulkader, Ihab; García‐Caballero, Tomás

doi:10.1902/jop.2009.090370

Cited by 13 publications

(18 citation statements)

References 22 publications

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“…Few verified cases of mucin-rich carcinoma of salivary gland origin have been described in the literature [2,[7][8][9][10]. The mean patient age is 57 years, with males more frequently affected than females.…”

Section: Discussionmentioning

confidence: 99%

Mucinous Carcinoma with Neuroendocrine Differentiation of Salivary Gland Origin

Wong

Zumsteg

Langevin

et al. 2016

Head and Neck Pathol

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Primary mucinous adenocarcinomas of the salivary gland are rare malignancies defined by aggregates of epithelial cells suspended in large pools of extracellular mucin. We report a case of a giant mucinous adenocarcinoma of salivary gland origin, with low-grade cytoarchitectural features and neuroendocrine differentiation arising in the submental region. Grossly, the tumor measured 12.5 9 13.4 9 8.2 cm and replaced the bone and soft tissues of the anterior oral cavity. Microscopically, the neoplasm was composed of large extracellular pools of mucin, which contained papillary and acinar aggregates, and small nodules of ductal type epithelium with minimal nuclear enlargement, powdery chromatin and little pleomorphism. The nodules comprised 20 % of the tumor and showed morphologic and immunohistochemical evidence of neuroendocrine differentiation. Examination revealed histologic features comparable to mammary gland analogues in mucin predominance, ductal type morphology, expression of estrogen and progesterone receptors, and GATA-3 positivity. This is the first case reported of mucin-rich carcinoma of salivary gland origin exhibiting neuroendocrine differentiation.

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Section: Discussionmentioning

confidence: 99%

Mucinous Carcinoma with Neuroendocrine Differentiation of Salivary Gland Origin

Wong

Zumsteg

Langevin

et al. 2016

Head and Neck Pathol

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“…Adjacent focus showed minor salivary gland proliferation. This finding suggest MAC of minor salivary gland origin [2][3][4].…”

Section: Discussionmentioning

confidence: 53%

“…These lesions pose diagnostic difficulties and are often misdiagnosed as pyogenic granuloma, mucus retention cyst, adenoma, or fibroma. Complete surgical excision is the primary therapy for an MAC [3,4]. Wide surgical excision of the growth was done in our case.…”

Section: Discussionmentioning

confidence: 80%

“…Mucinous adenocarcinoma is commonly seen in colon, pancreas, ovary, lung, prostate and breast [3][4][5]. Other atypical locations include nasal cavity, paranasal sinuses and mandibular ramus [5,6].…”

Section: Discussionmentioning

confidence: 99%

“…Only few cases of mucinous adenocarcinoma-cheek are reported till date in the literature. Males are frequently affected than females in the ratio of 3:1 with peak age of 5th-6th decade of life [1,3,4]. These patients usually present with painless exophytic growth, which clinically mimics adenoma, fibroma or pyogenic granuloma.…”

Section: Introductionmentioning

confidence: 99%

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Primary Mucinous Carcinoma of Buccal Mucosa: A Rare Case Report

Bhat

Prasad

Bhat

et al. 2014

Indian J Surg Oncol

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Minor salivary gland tumors of oral cavity are very rarely encountered in day-to-day practice. Mucinous adenocarcinoma is very rare, and is commonly seen in elderly males. Palate and buccal mucosa is the commonest site. Wide local excision is the treatment. Histology shows tumor cells floating in pools of mucin, compartmentalized by fibrous tissue. Metastasis is a close mimicker, however with an evidence of negative scan and minor salivary gland proliferation in adjacent tissue diagnosis can be made. Mucin stains and immunohistochemistry can be used to support the diagnosis in problematic cases. We are presenting a rare case of mucinous adenocarcinoma-cheek in a 54-year-old male who came with gradually progressive swelling in the left buccal mucosa since 3 months and after wide excision, no evidence of recurrence was noted in 1 year and 3 months of follow up period.

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Salivary mucinous adenocarcinoma of the mandible

et al. 2016

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Mucinous adenocarcinoma (MAC) is a malignancy rarely affecting the salivary glands, with fewer than 30 cases described in the medical literature. MAC is mostly observed in the minor salivary glands of the palate, and to date, no case of salivary MAC has been reported in the mandible. Identifying a salivary MAC may be both clinically and histopathologically challenging, as differential diagnosis must consider not only other salivary malignancies expressing a mucinous component but also metastases from MACs of the gastrointestinal tract, breast, and sweat glands that strongly resemble a salivary MAC on histopathology. We describe an 80-year-old man with a gingival overgrowth of the left mandible for the past 9 months, who was referred to our institution with an initial diagnosis of a periodontal reaction. On clinical examination, the mass mimicked a hyperplastic lesion; but after biopsy, the histopathologic pattern suggested a diagnosis of MAC. Herein, we present how comprehensive physical examination of the patient, immunohistochemistry study of the specimen, and radiological features helped in establishing the diagnosis of intraosseous salivary MAC, ruling out metastatic disease or other salivary neoplasms.

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Gingival Mucinous Adenocarcinoma of a Minor Salivary Gland

Cited by 13 publications

References 22 publications

Mucinous Carcinoma with Neuroendocrine Differentiation of Salivary Gland Origin

Mucinous Carcinoma with Neuroendocrine Differentiation of Salivary Gland Origin

Primary Mucinous Carcinoma of Buccal Mucosa: A Rare Case Report

Salivary mucinous adenocarcinoma of the mandible

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