Gingival mesenchymal stem cell therapy, immune cells, and immunoinflammatory application

Tolouei, Amir Ebrahimpour; Oruji, Farshid; Tehrani, Sahar; Rezaei, Sara; Mozaffari, Asieh; Jahri, Mohammad; Nasiri, Kamyar

doi:10.1007/s11033-023-08826-2

Cited by 4 publications

(1 citation statement)

References 63 publications

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“…Moreover, it is crucial to recognize that the manifestation of these reactions is impacted by systemic inflammation and metabolic and hormonal alterations [ 15 ]. Numerous recent studies have provided evidence of a noteworthy correlation between the ability to influence tumor progression directly and changes in tumor vascularization and blood flow, the metabolic utilization of substrates by malignant cells, the protein-level interactions between cancer cells and muscle tissue, and the modulation of immune function through physical exercise [ 16 , 17 ]. Extended periods of physical activity induce metabolic and immunogenic changes that hinder cancer progression [ 18 , 19 ].…”

Section: Association Of Physical Exercises and Breast Cancermentioning

confidence: 99%

Outcomes of physical exercises on initiation, progression, and treatment of breast cancer

Xu,

Jiao,

Bayat

2024

Cell Commun Signal

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The emergence of drug resistance is a substantial obstacle to the effective management of breast cancer, which is the primary cause of cancer-related deaths in women worldwide. To facilitate the development of targeted therapies that can effectively overcome drug resistance, it is crucial to possess a comprehensive comprehension of the molecular mechanisms that underpin resistance to breast cancer treatment. So far, considerable progress has been made in the field of exercise-oncology research and overcome drug resistance, specifically about breast cancer. Evidence has suggested that participation in physical activity is correlated with a decrease in reappearance and fatality rates of breast cancer patients. It has been reported that participation in physical activity can yield favorable outcomes in the prevention, treatment, and post-treatment of breast cancer. An increasing body of empirical evidence suggests that participation in physical activity can alter diverse biological mechanisms, potentially augmenting breast cancer treatments’ efficacy. Comparing increased physical activity versus reduced physical activity in breast cancer patients who received chemotherapy, radiotherapy, and surgery supported the significance of exercise in comprehensive care strategies to enhance overall health and treatment efficacy. Furthermore, previous studies have reported that physical activity can enhance the efficacy of breast cancer treatments. This review provides the current literature regarding the influence of physical activity on the occurrence and progression of breast cancer.

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Section: Association Of Physical Exercises and Breast Cancermentioning

confidence: 99%

Outcomes of physical exercises on initiation, progression, and treatment of breast cancer

Xu,

Jiao,

Bayat

2024

Cell Commun Signal

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Application of Engineered Dendritic Cell Vaccines in Cancer Immunotherapy: Challenges and Opportunities

Li,

Jia,

Bian

et al. 2023

Curr. Treat. Options in Oncol.

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Effects of oxidized LDL versus IL‐1ß/TNF‐ɑ/INFɣ on human gingival mesenchymal stem cells properties

Fawzy El‐Sayed,

Mahlandt,

Schlicht

et al. 2024

J of Periodontal Research

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AimsOxidized low‐density lipoprotein (oxLDL) is an important player in the course of metabolic inflammatory diseases. oxLDL was identified in the gingival crevicular fluid, denoting possible associations between oxLDL‐induced inflammation and periodontal disease. The current investigation compared for the first‐time direct effects of oxLDL to a cytokine cocktail of IL‐1ß/TNF‐ɑ/INF‐γ on gingival mesenchymal stem cells' (G‐MSCs) attributes.MethodsHuman third passage G‐MSCs, isolated from connective tissue biopsies (n = 5) and characterized, were stimulated in three groups over 7 days: control group, cytokine group (IL‐1β[1 ng/mL], TNF‐α[10 ng/mL], IFN‐γ[100 ng/mL]), or oxLDL group (oxLDL [50 μg/mL]). Next Generation Sequencing and KEGG pathway enrichment analysis, stemness gene expression (NANOG/SOX2/OCT4A), cellular proliferation, colony‐formation, multilinear potential, and altered intracellular pathways were investigated via histochemistry, next‐generation sequencing, and RT‐qPCR.ResultsG‐MSCs exhibited all mesenchymal stem cells' characteristics. oxLDL group and cytokine group displayed no disparities in their stemness markers (p > .05). Next‐generation‐sequencing revealed altered expression of the TXNIP gene in response to oxLDL treatment compared with controls (p = .04). Following an initial boosting for up to 5 days by inflammatory stimuli, over 14 day, cellular counts [median count ×10−5 (Q25/Q75)] were utmost in control – [2.6607 (2.0804/4.5357)], followed by cytokine – [0.0433 (0.0026/1.4215)] and significantly lowered in the oxLDL group [0.0274 (0.0023/0.7290); p = .0047]. Osteogenic differentiation [median relative Ca2+ content(Q25/Q75)] was significantly lower in cytokine – [0.0066 (0.0052/0.0105)] compared to oxLDL – [0.0144 (0.0108/0.0216)] (p = .0133), with no differences notable for chondrogenic and adipogenic differentiation (p > .05).ConclusionsWithin the current investigation's limitations, in contrast to cytokine‐mediated inflammation, G‐MSCs appear to be minimally responsive to oxLDL‐mediated metabolic inflammation, with little negative effect on their differentiation attributes and significantly reduced cellular proliferation.

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Gingival mesenchymal stem cell therapy, immune cells, and immunoinflammatory application

Cited by 4 publications

References 63 publications

Outcomes of physical exercises on initiation, progression, and treatment of breast cancer

Outcomes of physical exercises on initiation, progression, and treatment of breast cancer

Application of Engineered Dendritic Cell Vaccines in Cancer Immunotherapy: Challenges and Opportunities

Effects of oxidized LDL versus IL‐1ß/TNF‐ɑ/INFɣ on human gingival mesenchymal stem cells properties

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