Gingival Health in Relation to Salivary Vitamin C and Total Protein among Dental Students

Radhi, Nada Jafer Mh.

doi:10.12816/0015242

Cited by 3 publications

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“…In present study, we noticed elevated levels of total protein in periodontitis subjects, this increase in concentration may be attributed to modulation by extent of plasma protein exudation. Present study was in accordance with study conducted by Amita Ahire et al, Arati et al, Swati et al and Nada et al [14][15][16][17] Elevated levels of ROS levels were noted in the saliva of chronic periodontitis subjects. These elevated levels of ROS in saliva can result in imbalance between oxidants and antioxidants causing destruction of the periodontium leading to periodontitis.…”

Section: Discussionsupporting

confidence: 92%

Estimation of salivary glycoconjugates and salivary ros levels in chronic periodontitis: a clinico-biochemical study

Roy¹,

Manjunath²,

Bhat³

et al. 2017

Int J Res Med Sci

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Background: Periodontitis is a chronic inflammatory disease of periodontal tissue, characterized by persistent inflammation of the connective tissue and alveolar bone destruction. Patients with periodontal disease show the differences in the composition of saliva. Newer diagnostic tools based on analysis of body fluids such as saliva, GCF and serum are found to be useful for diagnosis as well as monitoring the disease activity. Thus, aim of the study was to estimate the concentration of salivary glycoconjugates (sialic acid, total protein) and salivary ROS in unstimulated whole saliva of subjects with chronic periodontitis and to compare the concentration with healthy/gingivitis subjects.Methods: The study sample consisted of 60 subjects (33 males and 27 females) with age ranging from 30-60 years. A detailed case history was taken from all the subjects and periodontal disease parameters (bleeding on probing, probing pocket depth and clinical attachment levels) were recorded at baseline and subjects were divided into 2 groups. Group I- control group (healthy/gingivitis subjects) and Group II -test group (chronic periodontitis). Saliva samples were collected from the subjects and stored at -700 ºC. Periodate Resorcinol Assay was done to estimate the levels of sialic acid, Biuret test was done to assess the levels of total protein and d-ROMs test was done to assess the level of ROS. Statistical analysis was done using students unpaired ‘t’ test and Pearsons correlation test. Results: It was found that the levels of salivary glycoconjugates and ROS are increased in subjects with chronic periodontitis when compared to healthy/gingivitis subjects. Thus it can reflect the clinical status of gingival and periodontal tissues.Conclusions: Estimation of the levels of glycoconjugates and ROS may be used as one of the reliable biomarkers to assess the severity of periodontal disease and to monitor the disease progression.

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Section: Discussionsupporting

confidence: 92%

Estimation of salivary glycoconjugates and salivary ros levels in chronic periodontitis: a clinico-biochemical study

Roy¹,

Manjunath²,

Bhat³

et al. 2017

Int J Res Med Sci

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“…Reactive oxygen species are involved in gum destruction when gingivitis occurs. An imbalance in oxidative activity may be a major factor in this inflammation, and the elevated TP level may provide a protective base against ROS [14]. Recent paper findings were indicated in Table 1, the highest concentration of TP in serum was in pregnant (9.11±0.99 gram (g)/deciliter (dl)) and non-pregnant women (8.60±1.33 g/dl) groups with gingivitis compared to healthy controls (5.91±0.87 g/dl) (P a1 =0.001 and P b1 =0.01, respectively).…”

Section: Resultsmentioning

confidence: 99%

“…In the same Table, the results revealed a significant elevation (P c1 =0.01) in the level of serum TP in pregnant gingivitis patients (9.11±0.99 g/dl) compared with non-pregnant gingivitis patients (8.60±1.33 g/dl). Thus, the elevated protein levels are likely due to contributions of acute phase interacting proteins, the concentration of which increases in serum during infection [14]. A significant (P a2 =0.001 and P b2 =0.01) higher level of protein in saliva was further observed in pregnant (0.56±0.11 g/dl) and non-pregnant women (0.51±0.18 g/dl) groups with gingivitis compared with healthy controls (0.25±0.09 g/dl) as in Table 2, and concentrations of salivary protein have been identified as biomarker of plasma protein leakage, which occurs as a result of the inflammatory process [1].…”

Section: Resultsmentioning

confidence: 99%

“…The elevated protein levels are likely due to protein contributions to the glandular saliva and flat fluid proteins. Thus, it has revealed a significant rise in gingivitis subjects, and may provide a pathway to improve oral healthcare [14]. Tables (1 and 2) depict NO levels in serum and saliva.…”

Section: Resultsmentioning

confidence: 99%

“…Antioxidants act as a free radical cleaning to reduce OS in the body and are believed to have a role in overall safety [11]. Antioxidants act collectively, and TAC may be the most relevant biomarker for assessing the defense capabilities [14]. It can prevent or slow down the harmful effect of free radicals and promote oral and general health [1].…”

Section: Introductionmentioning

confidence: 99%

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Untitled

2022

J. Med. Chem. Sci.

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Background: Gingivitis is an inflammation limited to marginal gingival tissues, which can be referred to as the mildest form of periodontal diseases, initial signs of inflammation which include: redness, bleeding, swelling, exudation, and to a lesser extent pain, which indicate the presence of gingivitis. Current research was proposed to detect the correlation between pregnancy status and oxidative stress (OS) levels among gingivitis pregnant women and to elucidate the role of pregnancy status in the pathogenicity of gingivitis. Methods: The current study was conducted in the Dental Center at Thi-Qar province (Iraq), and it included three study groups: 35 pregnant women with gingivitis, 35 non-pregnant women with gingivitis, and 30 non-pregnant women without gingivitis (the healthy control), with an age balance between the three study groups. Serological and salivary levels of malondialdehyde (MDA), total anti-oxidant capacity (TAC), protein carbonyl (Pc), protein, nitric oxide (NO), and ceruloplasmin (Crp) were biochemically determined. Results:The results of the tests showed that the concentrations of MDA, Pc, the total proteins (TP), NO, and Crp were significantly higher among pregnant and non-pregnant women with gingivitis compared with healthy controls in both serum and saliva, whereas the inverse findings were reported for TCA biomarker. The same results profiles were reported in comparison between pregnant women with gingivitis and non-pregnant women with gingivitis for serum biomarkers. For saliva biomarkers, the results revealed significant elevated levels of MDA, Pc, and NO among pregnant gingivitis women in comparison with non-pregnant gingivitis, whereas the other biomarkers revealed non-significant differences. Conclusions: The pregnancy status had an effect on the OS level which lead to a higher level of OS in both serum and saliva and the correlation between the pregnancy status and serum and/or saliva OS levels was positive which indicated the possible utility of its present lead to gingivitis development.

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Influence of Vitamin D Deficiency on the Level of Salivary cathelicidin LL-37 in relation to Dental Caries Experience: A Case-Control Study

Alhelfi

Hobi

2023

Al-Kindy Col. Med. J

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Background: Vitamin D improves innate immunity by enhancing the expression of antimicrobial peptides. The antimicrobial action of cathelicidin is widespread and effective against cariogenic bacteria. This research aimed to investigate the effect of vitamin D deficiency on the level of salivary cathelicidin concerning dental caries experience. Subjects and Methods: A case-control study was carried out, and the sample was composed of 80 females; the study group involved 40 females with a serum vitamin D concentration of less than 10 ng/ml. In addition to the control group involving 40 females who matched the case in number and age but serum vitamin D concentration of 30 ng/mol or more, their age range was 20-30 years. WHO 2013 index was used for the assessment of dental caries experience, and collection of unstimulated saliva was done to measure salivary cathelicidin. Results: Data from the current study showed that the mean values of the Decayed, Missing, and Filled Teeth index and its components (Decayed Teeth, Missing Teeth) were higher in the study group than those in the control one, with a significant difference for Decayed Teeth. Salivary cathelicidin was higher in the control group with a statistically significant difference. Conclusion: It was confirmed that serum vitamin D status and salivary cathelicidin levels are related. Vitamin D deficient patients who had higher Decayed, Missing, and Filled Teeth index values expressed a lower level of salivary cathelicidin than the control group.

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Gingival Health in Relation to Salivary Vitamin C and Total Protein among Dental Students

Cited by 3 publications

References 0 publications

Estimation of salivary glycoconjugates and salivary ros levels in chronic periodontitis: a clinico-biochemical study

Estimation of salivary glycoconjugates and salivary ros levels in chronic periodontitis: a clinico-biochemical study

Untitled

Influence of Vitamin D Deficiency on the Level of Salivary cathelicidin LL-37 in relation to Dental Caries Experience: A Case-Control Study

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