Gingival Crevicular Fluid Osteopontin Levels in Periodontal Health and Disease

Sharma, Dileep; Pradeep, A.R.

doi:10.1902/jop.2006.060016

Cited by 38 publications

(41 citation statements)

References 22 publications

(29 reference statements)

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“…The increased recognition of the interactions between the cells of the immune and skeletal system has led to the seeking of a variety of regulatory molecules that play a role in the progression of periodontal disease [25][26][27]. In previous studies, the bestknown markers of the bone turnover have been widely investigated in GCF samples of patients with different periodontal diseases and implicated to be associated with the progression of periodontal diseases [28][29][30]. Several investigations provided contradictory evidence about the role of osteocalcin in GCF of patients with periodontitis [31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

et al. 2011

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Abstract. Aim:The aim of the present study was to investigate gingival crevicular fluid (GCF) calprotectin, osteocalcin and cross-linked N-terminal telopeptide (NTx) levels in health along with different periodontal diseases. Material and methods: Twenty chronic periodontitis (CP), 20 generalized aggressive periodontitis (G-AgP), 20 gingivitis and 20 healthy subjects were included. Probing depth, clinical attachment level, plaque index and papillary bleeding index was recorded. GCF calprotectin, osteocalcin and NTx levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Results: CP, G-AgP and gingivitis groups had higher GCF calprotectin total amount compared to healthy subjects (p < 0.008). CP and G-AgP groups had similar, but higher levels compared to gingivitis groups (p < 0.008). CP and G-AgP groups had lower GCF osteocalcin total amount compared to gingivitis and healthy groups (p < 0.008). CP group had higher GCF NTx but lower osteocalcin total amount and osteocalcin/NTx ratio than the G-AgP group (p < 0.008). Conclusions: Our results suggest that elevated GCF calprotectin levels play a role as a reliable inflammatory marker in the pathogenesis of periodontal disease. Fluctuating GCF levels of osteocalcin and NTx might point out to the abnormal bone turnover in periodontitis. Our data document for the first time the role of NTx in the pathogenesis of different periodontal diseases.

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Section: Introductionmentioning

confidence: 99%

Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

et al. 2011

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“…OPN, is mainly involved in enhancing osteoclastic action and has also been detected in GCF in some aforementioned studies. 24,25 The effects of initial periodontal therapy also confirmed that OPN levels significantly decreased and were correlated with decreasing clinical periodontal parameters. 25 Kido et al reported that OPN in GCF may be considered as a marker of alveolar bone loss in periodontitis, while Sharma and Pradeep reported that GCF OPN levels were higher in periodontitis patients compared to those with gingivitis and healthy subjects.…”

mentioning

confidence: 74%

“…24,25 The effects of initial periodontal therapy also confirmed that OPN levels significantly decreased and were correlated with decreasing clinical periodontal parameters. 25 Kido et al reported that OPN in GCF may be considered as a marker of alveolar bone loss in periodontitis, while Sharma and Pradeep reported that GCF OPN levels were higher in periodontitis patients compared to those with gingivitis and healthy subjects. 24,25 Conversely, the present study showed similar total amounts of OPN GCF levels in all geriatric groups.…”

mentioning

confidence: 74%

“…25 Kido et al reported that OPN in GCF may be considered as a marker of alveolar bone loss in periodontitis, while Sharma and Pradeep reported that GCF OPN levels were higher in periodontitis patients compared to those with gingivitis and healthy subjects. 24,25 Conversely, the present study showed similar total amounts of OPN GCF levels in all geriatric groups. Neighboring tissues including alveolar bone and cementum, macrophages in periodontal tissues, blood and salivary glands function as the source of OPN in GCF.…”

mentioning

confidence: 99%

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Comparison Of Bone Turnover Markers In Gingival Crevicular Fluid Of Elderly Individuals With Different Periodontal Diseases

Öztürk¹,

Becerik²,

Atmaca³

et al. 2016

EÜ Dişhek Fak Derg

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“…Several investigations on OPN indicated that OPN concentrations in gingival crevicular fluid increased proportionally with the progression of disease; and OPN levels in GCF were significantly reduced following nonsurgical periodontal treatment (33,34).…”

Section: Markers Of Alveolar Bone Lossmentioning

confidence: 99%

Recent Advances in Salivary Proteomics, Genomics and Transcriptomics: A Reliable Tool in Periodontal diagnosis – A Review

Rajapriya

Saravanan

et al. 2014

ADUM

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Aim: This review intends to provide a highlight on the potential application of salivary proteomics in periodontal diagnosis and attempts to throw light on the emerging salivary diagnostic tools for periodontal disease detection. Background: Clinical parameters for detection of periodontitis such as probing depth, attachment level, bleeding on probing, plaque index, and radiographic assessment of alveolar bone loss provide information on the severity of periodontitis, but they do not measure disease activity. Ideally, development and application of rapid and simple diagnostic tests based on host salivary or immune factors may facilitate early detection of patients at risk for periodontal diseases, allow appropriate intervention, decrease the need for more aggressive treatment and improve the response to periodontal therapy. Results: Studies have shown that saliva could be used as a diagnostic fluid as it is one of the inexpensive, noninvasive and easy-to-use diagnostic methods. Salivary constituents that have been studied as potential diagnostic biomarkers for periodontal disease includes locally produced proteins of host and bacterial origin, genetic/genomic biomarkers such as DNA and mRNA of host origin, bacteria and bacterial products, ions, steroid hormones and volatile compounds. Conclusion: Periodontal oral diagnostic devices will enable screening of large populations, more quickly and effectively. Use of salivary biomarkers to sample large populations will help to identify at-risk groups more effectively and increase access to treatment for those most at need, thereby, improving public health.

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Gingival Crevicular Fluid Osteopontin Levels in Periodontal Health and Disease

Abstract: OPN levels increase in GCF from healthy to periodontitis states, and periodontal treatment results in the reduction of OPN levels. The data indicate that OPN may play a key role in, and could be considered a biomarker of, periodontal disease progression.

Cited by 38 publications

References 22 publications

Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

Comparison Of Bone Turnover Markers In Gingival Crevicular Fluid Of Elderly Individuals With Different Periodontal Diseases

Recent Advances in Salivary Proteomics, Genomics and Transcriptomics: A Reliable Tool in Periodontal diagnosis – A Review

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