Gingival Crevicular Fluid Alkaline Phosphatase Levels in Postmenopausal Women: Effects of Phase I Periodontal Treatment

Abstract

These data suggest that the presence of ALP in GCF is not simply a reflection of the local inflammation state and that a patient's estrogen status may possibly influence local ALP levels in GCF.

Assessment of the alkaline phosphatase level in gingival crevicular fluid, as a biomarker to evaluate the effect of scaling and root planing on chronic periodontitis: An in vivostudy

“…The GCF serum ratio for clinically healthy periodontal tissues ranged from 6:1 to 12:1, which implies that the enzyme is locally produced within the periodontium. [28] Thus, gingival crevicular fluid ALP levels from periodontal pockets can be taken as indicative for active periodontal tissue destruction. Chapple et al .…”

Correlación entre los niveles de fosfatasa alcalina salival y la profundidad de la bolsa periodontal

“…La fal tiene la particularidad de estar involucrada con la inflamación y con la reparación/regeneración, utilizándose como un marcador inflamatorio del periodonto, así como del metabolismo óseo, mediante su dosaje en fgc y suero [10][11][12][13].…”

Comparison Of Bone Turnover Markers In Gingival Crevicular Fluid Of Elderly Individuals With Different Periodontal Diseases

“…16 Daltaban et al reported higher GCF ALP levels in post-menopausal women with periodontitis than in the clinically healthy control group. 17 A recent study, demonstrated low levels of GCF ALP in non-destructive and slightly destructive periodontitis sites, whereas significantly high levels of ALP were observed in moderately and severely destructive sites. 18 In the present study, there was no significant difference between the study groups including between CP and H suggesting that the destruction was moderate in the sampling sites of the CP group or might be even a little destruction or subclinical inflammation in H group.…”

“…26,27 It is well known that the homeostasis in bone turnover is disturbed during the progression of periodontal disease and leads to irreversible bone resorption where the immune cells and cytokines released play an important role. 17 The presence of measurable amounts of GCF ALP, OC, OPN, OPG and PTH in the CP, G and H groups might be due to the bone homeostasis process independently ageing. Our study results, for the first time, demonstrated the presence of bone turnover markers in the GCF of elderly individuals with different periodontal disease.…”

“…16 Although its exact function is not fully understood, ALP is required on the cell membrane for bone mineralization. 17 Ishikawa et al showed that GCF ALP levels were significantly higher in both chronic and aggressive periodontitis patients than healthy subjects. 15 GCF ALP is correlated with increased gingival index.…”