Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients

Abstract

Purpose Despite the widespread use of antiemetics, nausea continues to be reported by over 70% of patients receiving chemotherapy. Methods In this double blind, multicenter trial, we randomly assigned 744 cancer patients to four arms: 1) placebo, 2) 0.5g ginger, 3) 1.0g ginger, or 4) 1.5g ginger. Nausea occurrence and severity were assessed at a baseline cycle and the two following cycles during which patients were taking their assigned study medication. All patients received a 5-HT3 receptor antagonist antiemetic on Day 1 of all cycles. Patients took three capsules of ginger (250mg) or placebo twice daily for six days starting three days before the first day of chemotherapy. Patients reported the severity of nausea on a 7-point rating scale (“1” = “Not at all Nauseated” and “7” = “Extremely Nauseated”) for Days 1-4 of each cycle. The primary outcomes were to determine the dose and efficacy of ginger at reducing the severity of chemotherapy-induced nausea on Day 1 of chemotherapy. Results A total of 576 patients were included in final analysis (91% female, mean age = 53). Mixed model analyses demonstrated that all doses of ginger significantly reduced acute nausea severity compared to placebo on Day 1 of chemotherapy (p=0.003). The largest reduction in nausea intensity occurred with 0.5g and 1.0g of ginger (p=0.017 and p=0.036, respectively). Anticipatory nausea was a key factor in acute chemotherapy-induced nausea (p<0.0001). Conclusions Ginger supplementation at daily dose of 0.5g-1.0g significantly aids in reduction of the severity of acute chemotherapy-induced nausea in adult cancer patients.

In silico investigation into the interactions between murine 5-HT3 receptor and the principle active compounds of ginger (Zingiber officinale)

“…Indeed, clinical trials have reported a significant improvement in CINV where ginger was combined with standard treatment with a setron class drug. [22,30] Recently, the crystal structure of the murine 5-HT3 receptor in the apo (or unbound) form was solved using X-ray crystallography at 3.5Å resolution (Figure 2). [5] Prior to this, structural studies had relied on homology models using templates from other CYS loop receptors.…”

Análise Sistemática Da Produção Científica Do Zingiber Officinale Roscoe Após a Criação Da Relação Nacional De Plantas Medicinais De Interesse Ao Sistema Único De Saúde

“…(25) . Referentes aos 19 estudos restantes foram abordadas as seguintes propriedades terapêuticas com pesquisas envolvendo o gengibre: tratamento da náusea induzida por quimioterapia (26) , função para absorção de Ferro, Zinco e Cálcio (27) , analgésico (28) , antidependência contra o uso crônico da morfina (29) , anti-inflamatório (30) , antimicrobiano (31) , combate à ação da artrite reumatoide (32) , aumento da proteólise muscular em patos (33) , tratamento do câncer de mama (14) , citoprotetor (15) , combate ao vírus sincicial respiratório humano (VSR) (34) , combate a sintomas da Doença de Alzheimer (35) , tratamento da fibrose hepática (36) , proteção contra a genotoxicidade (37) , inibição da enzima Angiotensina I (38) , inibição da motilidade do cólon (39) , atenuação da isquemia cerebral (40) , redução da nefrotoxicidade (41) e neuroprotetor (42) , as quais tiveram um estudo cada publicadas durante o período de análise.…”

Complementary and alternative theraphy methods used in the management of chemotherapy induced nausea and vomiting

“…Bu alanda yapılan çalışmaların daha çok zencefil üzerinde yoğunlaştığı ve bulantı kusma yönetiminde zencefil kullanıldığı görülmektedir. [23][24][25][26][27][28][29][30] Dünyanın pek çok bölgesinde yaygın kullanımı olan zencefil, genellikle baharat ya da gıda desteği olarak geleneksel tıpta yüzlerce yıldır kullanılmaktadır. Roma, Çin, Yunan ve Osmanlı tıp tarihi kayıtları zencefilin tıbbi bir bitki olarak kullanıldığını göstermektedir.…”