Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation

Ahui, Marie Louise Berthe; Champy, Pierre; Ramadan, Abdulraouf; Pham, Linh; Araujo, Luiza M.; André, Konan Brou; Diem, Séverine; Damotte, Diane; Kati-Coulibaly, Séraphin; Offoumou, Michel Atté; Dy, Michel; Thiéblemont, Nathalie; Herbelin, André

doi:10.1016/j.intimp.2008.07.009

Cited by 87 publications

(41 citation statements)

References 38 publications

(51 reference statements)

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“…The average yield of the crude extract is 10.23 ± 1.02%. This result is in agreement with those reported by Tejasari [15] (10.2%), Tewtrakul and Subhadhirasakul [22] (11.4% and 10.4%), and Ahui et al [26] (11%). However, it is higher than those obtained by Mascolo et al [6] (2.8%), Alfaro et al [27] (3.6, 3.2, and 0.27%), and Goyal and Kadnur [28] (4.6 and 4.3%).…”

Section: Results and Discussion Extraction Yieldssupporting

confidence: 93%

Antioxidant Activity of the Essential Oil and Oleoresin ofZingiber OfficinaleRoscoe as Affected by Chemical Environment

Bellik

Benabdesselam

Ayad

et al. 2013

International Journal of Food Properties

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Three different biochemical test systems were chosen based on their solubility to study the antioxidant activity of ginger extracts. Reducing power and DPPH . scavenging activity tests were considered to produce hydrophilic environments and the H 2 O 2 test was considered as creating a lipophilic environment. The average yields were 10.23 ± 1.02% and 0.48 ± 0.19% for oleoresin and essential oil, respectively. The content of total phenols was 67.6 ± 1.08 mg GAE/g of dry extract. In terms of EC 50 , in hydrophilic environment standards, it showed the highest effects compared to ginger extracts, with oleoresin presenting more activity than essential oil. In contrast, except for quercetin, essential oil showed the best scavenging activity in inhibiting H 2 O 2 compared to all other antioxidants. The present work demonstrated that, when using reducing power, DPPH· free radical scavenging and H 2 O 2 scavenging assays, the same ginger extracts exhibit different antioxidant activities, which were affected not only by the extract itself but also by the chemical environment (hydrophilic/lipophilic).

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Section: Results and Discussion Extraction Yieldssupporting

confidence: 93%

Antioxidant Activity of the Essential Oil and Oleoresin ofZingiber OfficinaleRoscoe as Affected by Chemical Environment

Bellik

Benabdesselam

Ayad

et al. 2013

International Journal of Food Properties

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“…It has been demonstrated that gingerols can inhibit TNF-␣ expression in the liver, nervous system, and other tissues (16,53). Also, it is known that gingerols reduce the expression of IL-2 and IFN-␥ by T cells (54,55). These GM-induced inflammatory molecules participate in the pathogenesis of tubulointerstitial impairment through the promotion of leukocyte attraction and adhesion to inflamed renal tubular cells.…”

Section: Figmentioning

confidence: 99%

Gingerol Fraction from Zingiber officinale Protects against Gentamicin-Induced Nephrotoxicity

Rodrigues

Prata

Oliveira

et al. 2014

Antimicrob Agents Chemother

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. Histopathological findings of tubular degeneration and inflammatory cell infiltration reinforced GM-induced nephrotoxicity. All these alterations were attenuated by previous oral treatment with GF. Animals from the GM؉GF groups showed amelioration in renal function parameters and reduced lipid peroxidation and nitrosative stress, in addition to an increment in the levels of glutathione (GSH) and superoxide dismutase (SOD) activity. Gingerols also promoted significant reductions in mRNA transcription for TNF-␣, IL-2, and IFN-␥. These effects were dose dependent. These results demonstrate that GF promotes a nephroprotective effect on GM-mediated nephropathy by oxidative stress, inflammatory processes, and renal dysfunction.

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“…Aqueous extract of ginger, enriched of gingerols, injected i.p. before airway challenge of ovalbumin -sensitized mice resulted in suppressing Th2-mediated immune responses and might thus provide a possible therapeutic application in allergic asthma [21,22].…”

Section: Introductionmentioning

confidence: 99%

Experimental immunology The effect of multi-component herbal remedy PERVIVO on cellular immunity and tumor angiogenesis in mice

Bałan¹,

Stankiewicz²,

Skopińska-Różewska³

et al. 2013

cejoi

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Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation

Cited by 87 publications

References 38 publications

Antioxidant Activity of the Essential Oil and Oleoresin ofZingiber OfficinaleRoscoe as Affected by Chemical Environment

Antioxidant Activity of the Essential Oil and Oleoresin ofZingiber OfficinaleRoscoe as Affected by Chemical Environment

Gingerol Fraction from Zingiber officinale Protects against Gentamicin-Induced Nephrotoxicity

Experimental immunology The effect of multi-component herbal remedy PERVIVO on cellular immunity and tumor angiogenesis in mice

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