Ginger Nanoparticles Modulate the Apoptotic Activity in Male Rats Exposed to Dioxin-Induced Cancer Initiation

Abdu, Suzan Bakr; Abdu, Faiza; Khalil, Wagdy K. B.

doi:10.3923/ijp.2017.946.957

Cited by 12 publications

(6 citation statements)

References 42 publications

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“…181,182 Apoptotic activity as a protective action of GDENs against the 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD) in colon cancer in male rats was evaluated and the results showed that GDENs controlled the ratio of these proteins and the expression of Bcl-2, Bax, and p53 genes, reduced the amount of necrosis/apoptosis, and inhibited the initiation of colon cancer. 183 In another study, GDENs modified by folic acid could be adsorbed by colon cancer cells more efficiently. Modified folic acidconjugated GDENs deliberately transferred a therapeutic agent (doxorubicin) to colon 26 tumors in vivo and thus increased the effect of chemotherapy to inhibit tumor growth as compared to the free drug.…”

Section: Cancersmentioning

confidence: 97%

A comprehensive review on ginger-derived exosome-like nanoparticles as feasible therapeutic nano-agents against diseases

Bahri,

Mansoori,

Vafaei

et al. 2024

Mater. Adv.

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Section: Cancersmentioning

confidence: 97%

A comprehensive review on ginger-derived exosome-like nanoparticles as feasible therapeutic nano-agents against diseases

Bahri,

Mansoori,

Vafaei

et al. 2024

Mater. Adv.

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“…It also modulates the apoptotic genes to reduce the rate of apoptosis. [ 46 ] The dietary ELNs can also be employed to deliver chemotherapeutic drugs with better efficacy and reduced side effects. [ 47 ]…”

Section: Potential Health Benefits and Clinical Relevance Of Dietary ...mentioning

confidence: 99%

Dietary Exosome‐Like Nanoparticles: An Updated Review on Their Pharmacological and Drug Delivery Applications

Anusha

Priya

2022

Molecular Nutrition Food Res

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Exosomes are lipid bilayer membrane‐bound extracellular vesicular structures (30–150 nm) mainly released by eukaryotic cells of animal origin. Exosome‐like nanoparticles (ELNs) are the vesicular structures originating from plant sources with features similar to eukaryotic animal cell derived exosomes. ELNs derived from dietary sources (dietary ELNs) have exceptional pharmacological potential in alleviating many diseases and are good in maintaining intestinal health through the manipulation of the gut microbiome. The dietary ELNs being highly biocompatible find their application in targeted therapy as well. They are being established as promising drug delivery agents and can also be developed into dietary supplements. This review highlights the ELNs derived from various dietary sources, their diversity in molecular compositions, potential health benefits, and drug delivery applications. Few clinical trials are attempted with dietary ELNs which are also described in the review along with their properties that can be exploited for the food and pharma industries in the future.

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“…A. Alasmari : Hepatoprotective activity of Dodonaea viscosa leaf extract 179 DNA adducts determination: The formation ratio of DNA adducts was assessed in hepatic tissues of all treated animals according to Abdu et al (2017). The isolation of genomic DNA from the hepatic tissues of treated rats was performed following chloroform/isoamyl method.…”

Section: O N L I N E C O P Ymentioning

confidence: 99%

Hepatoprotective activity of Dodonaea viscosa leaf extract nanoparticles against N-nitrosodiethylamine induced tumor initiation in rat liver: Modulation of apoptosis and signaling pathways

Alasmari¹

2022

JEB

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Aim: To evaluate the hepatoprotective activity of extract and silver nanoparticles of Dodonaea viscose leaves against hepatocellular carcinoma in male rats. Methodology: Eighty adult Wistar male rats were exposed to N-nitrosodiethylamine to induce hepatocellular carcinoma and allocated in different groups supplemented with 125, 250 and 500 mg kg-1 b.wt. of Dodonaea viscosa (DVLE) and DVLE-AgNPs for 12 weeks. Liver samples of treated groups were used to estimate the activities of alanine transaminase (ALT), aspartate aminotransferase (AST), glutathione peroxidase (GPx) and albumin levels. DNA damage, DNA adducts, ROS generation, apoptosis rate, and the expression analysis of the genes associated with the apoptosis (Bcls, Bax and p53) were also determined. Results: HCC group exhibited alterations in the activities of ALT, AST, GPx and levels of albumin compared with the control group. High rates of DNA damage, DNA adducts and ROS generations as well as changes in the apoptosis rates and the expression levels of Bcls, Bax and p53 genes were observed in HCC-induced rats compared with those in control group. DVLE and DVLE-AgNPs prevented the NDEA action on liver damage in a dose-dependent manner by reducing the alteration in the enzymatic and protein levels, decrease ROS generation, diminish genetic toxicity (DNA damage and DNA adducts), increased the apoptosis rate and suppressed the expression changes of Bcls, Bax and p53 genes. Interpretation: The action mechanism of DVLE and DVLE-AgNPs could probably attribute to the presence of polyphenolic and sesquiterpenes which are considered as potent inhibitors of cancer progression of liver cells.

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Ginger Nanoparticles Modulate the Apoptotic Activity in Male Rats Exposed to Dioxin-Induced Cancer Initiation

Cited by 12 publications

References 42 publications

A comprehensive review on ginger-derived exosome-like nanoparticles as feasible therapeutic nano-agents against diseases

A comprehensive review on ginger-derived exosome-like nanoparticles as feasible therapeutic nano-agents against diseases

Dietary Exosome‐Like Nanoparticles: An Updated Review on Their Pharmacological and Drug Delivery Applications

Hepatoprotective activity of Dodonaea viscosa leaf extract nanoparticles against N-nitrosodiethylamine induced tumor initiation in rat liver: Modulation of apoptosis and signaling pathways

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