Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells

Abstract

Background: Ginger (Zingiber officinale Rosc) is a natural dietary component with antioxidant and anticarcinogenic properties. The ginger component [6]-gingerol has been shown to exert antiinflammatory effects through mediation of NF-κB. NF-κB can be constitutively activated in epithelial ovarian cancer cells and may contribute towards increased transcription and translation of angiogenic factors. In the present study, we investigated the effect of ginger on tumor cell growth and modulation of angiogenic factors in ovarian cancer cells in vitro.

Effects and Interactions of Ginger and Propranolol in Pre-Hepatic Portal Hypertensive Rats

“…[31] Moreover, ginger could decrease the inflammatory mediators like TNF-α, interleukin-1β (IL-1β), carbon monoxide (CO) and IL-10 [25]. In the same context, the potential antimicrobial effect of ginger [32] as well as inhibition of angiogenesis [33] could share in the reduction of portal pressure.…”

Herbal Antioxidants as Rejuvenators in Alternative Medicine

“…It is used both in fresh and dried form to treat nausea and vomiting (Jewell, 2003;Borrelli et al, 2005;Chaiyakunapruk et al, 2006), osteo and rheumatoid arthritis (Srivastava and Mustafa, 1992;Bliddal et al, 2000;Altman and Marcussen, 2001), diabetes mellitus (Sekiya et al, 2004;Goyal and Kadnur, 2006;Heimes et al, 2009), indigestion and some cardiovascular disorders (Jiang et al, 2005;Nicoll and Henein, 2009). Various studies have demonstrated the anti-oxidant (Kabuto et al, 2005;Ahmed et al, 2008;Pan et al, 2008;Dugasani et al, 2010), anti-inflammatory (Young et al, 2005), anti-cancer (Jiang et al, 2005;Rhode et al, 2007;Shukla and Singh, 2007) and anti-microbial Singh et al, 2008b) properties of ginger. These multiple biological properties of ginger support its clinical application as an herbal rejuvenator.…”

“…Another study indicated that 6-gingerol has been reported to inhibit NO synthesis and protect against peroxynitrite-mediated damage (Ippoushi et al, 2003). Apart from these, several studies investigating the anti-cancer potential of ginger have reported the involvement of signaling molecules such as NF-κB, TNF-, AKT, ERK1/2, p38 MAPK, MMP-2 and MMP-9 in mediating the cellular responses to various phytochemicals of ginger (Rhode et al, 2007;Habib et al, 2008;Hung et al, 2009;Yodkeeree et al, 2009;Kim et al, 2010).…”

Phychemistry, Phytochemical, Pharmacological and Molecular Study of Zingiber Officinale Roscoe: A Review

“…In another study, 6-gingerol of ginger showed the antioxidant property and it also defends HL-60 cells from oxidative stress [75]. In a research conducted by Mallikarjuna et al [76] found that ethanol considerably decreases the superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione content in the hepatic tissue.…”