Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms

Ishiguro, Kazuhiro; Ando, Takafumi; Maeda, Osamu; Ohmiya, Naoki; Niwa, Yasumasa; Kadomatsu, Kenji; Goto, Hidemi

doi:10.1016/j.bbrc.2007.08.012

Cited by 127 publications

(92 citation statements)

References 23 publications

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“…3-Nonen-2-one disrupted the distribution of tubulin (Fig. 2) in a manner similar to that observed in the cells treated with 6-shogaol [9], while nonan-2-one and 3-nonene did not (Fig. 2).…”

Section: Resultssupporting

confidence: 76%

“…1A). Unlike 6-gingerol, we have previously shown that 6-shogaol damages microtubules, induces mitotic arrest and reduces the viability of gastric cancer cells (HGC-27 cells, IC50 = 6 lM; AGS cells, 6 lM; Kato cells, 10 lM), and that the administration of 6-shogaol suppresses the growth of tumor transplanted to nude mice [9]. 6-Shogaol contains the structure -C‚C-near the carbonyl group, while 6-gingerol does not.…”

Section: Resultsmentioning

confidence: 99%

“…The active ingredients in ginger are 6-shogaol and 6-gingerol, which are stable within 1 h in the simulated gastric fluid [8]. Interestingly, 6-shogaol and 6-gingerol reduce the viability of gastric cancer cells via different mechanisms [9]. 6-Shogaol reduces viability by damaging microtubules and inducing mitotic arrest.…”

Section: Introductionmentioning

confidence: 99%

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Specific reaction of α,β‐unsaturated carbonyl compounds such as 6‐shogaol with sulfhydryl groups in tubulin leading to microtubule damage

et al. 2008

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6-Shogaol and 6-gingerol are ginger components with similar chemical structures. However, while 6-shogaol damages microtubules, 6-gingerol does not. We have investigated the molecular mechanism of 6-shogaol-induced microtubule damage and found that the action of 6-shogaol results from the structure of a,b-unsaturated carbonyl compounds. a,b-Unsaturated carbonyl compounds such as 6-shogaol react with sulfhydryl groups of cysteine residues in tubulin, and impair tubulin polymerization. The reaction with sulfhydryl groups depends on the chain length of a,b-unsaturated carbonyl compounds. In addition, a,b-unsaturated carbonyl compounds are more reactive with sulfhydryl groups in tubulin than in 2-mercaptoethanol, dithiothreitol, glutathione and papain, a cysteine protease.

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“…3-Nonen-2-one disrupted the distribution of tubulin (Fig. 2) in a manner similar to that observed in the cells treated with 6-shogaol [9], while nonan-2-one and 3-nonene did not (Fig. 2).…”

Section: Resultssupporting

confidence: 76%

Section: Resultsmentioning

confidence: 99%

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Specific reaction of α,β‐unsaturated carbonyl compounds such as 6‐shogaol with sulfhydryl groups in tubulin leading to microtubule damage

et al. 2008

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“…More recent studies have suggested that gingerols exhibit preventive activity against cancers of the skin [10] , pancreas [11] , gastrointestinal tract [12] , colon [13] , and breast [14] . Ginger can also effectively prevent nausea induced by cancer treatment [15] .…”

Section: Introductionmentioning

confidence: 99%

Pungent ginger components modulates human cytochrome P450 enzymes in vitro

Chen

Yue

et al. 2013

Acta Pharmacol Sin

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Aim: Ginger rhizome is used worldwide as a spicy flavor agent. This study was designed to explore the potential effects of pungent ginger components, 6-, 8-, and 10-gingerol, on human cytochrome P450 (CYP450) enzymes that are responsible for the metabolism of many prescription drugs. Methods: The activities of human CYP2C9, CYP2C19, CYP2D6, and CYP3A4 were analyzed using Vivid P450 assay kits. The mRNA expression of CYP3A4 in human hepatocellular carcinoma cell line HepG2 was measured using quantitative real-time PCR assay. Results: All three gingerols potently inhibited CYP2C9 activity, exerted moderate inhibition on CYP2C19 and CYP3A4, and weak inhibion on CYP2D6. 8-Gingerol was the most potent in inhibition of P450 enzymes with IC 50 values of 6.8, 12.5, 8.7, and 42.7 μmol/L for CYP2C9, CYP2C19, CYP3A4, and CYP2D6, respectively. By comparing the effects of gingerols on CYP3A4 with three different fluorescent substrate probes, it was demonstrated that the inhibition of gingerols on CYP3A4 had no substrate-dependence. In HepG2 cells, 8-gingerol and 10-gingerol inhibited, but 6-gingerol induced mRNA expression of CYP3A4. Conclusion: 6-, 8-, and 10-gingerol suppress human cytochrome P450 activity, while 8-and 10-gingerol inhibit CYP3A4 expression. The results may have an implication for the use of ginger or ginger products when combined with therapeutic drugs that are metabolized by cytochrome P450 enzymes.

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“…Remarkably, 10-gingerol was about 50-fold more potent (IC50 = 12 versus 670 µM, respectively) than 6-gingerol [39]. Ginger and its bioactive molecules are effective in regulatory the degree of colorectal, gastric, ovarian, liver, skin, breast, and prostate cancers [40,[42][43][44][45][46][47]. Kim et al [45] have carried out an experiment in mouse models and administered Zerumbone orally and observed inhibition in a multiplicity of colonic adenocarcinomas through suppression of colonic inflammation in a dose-dependent manner.…”

Section: Anti-cancer Effectsmentioning

confidence: 99%

Phychemistry, Phytochemical, Pharmacological and Molecular Study of Zingiber Officinale Roscoe: A Review

Ashraf

Sultan

Shah³

2017

Int J Pharm Pharm Sci

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The rhizomes of Zingiber officinale Roscoe (Zingiberaceae), commonly known as ginger, is one of the most widely used spice and condiment. It is also an integral part of many traditional medicines and has been extensively used in Chinese, Ayurvedic, Tibb-Unani, Srilankan, Arabic, and African traditional medicines, since antiquity, for many unrelated human ailments including common colds, fever, sore throats, vomiting, motion sickness, gastrointestinal complications, indigestion, constipation, gastritis, epigastric discomfort, gastric ulcerations, indigestion, nausea vomiting etc, and scientific studies have validated the ethnomedicinal uses. The present review tries to summarize and document the phytochemistry, phytochemical, pharmacological and molecular work done on ginger. The data was compiled to provide consolidated information covering different aspects of the plant, to provide a basis on which to plan future studies and to promote sustainable use of Z. officinale.

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Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms

Cited by 127 publications

References 23 publications

Specific reaction of α,β‐unsaturated carbonyl compounds such as 6‐shogaol with sulfhydryl groups in tubulin leading to microtubule damage

Specific reaction of α,β‐unsaturated carbonyl compounds such as 6‐shogaol with sulfhydryl groups in tubulin leading to microtubule damage

Pungent ginger components modulates human cytochrome P450 enzymes in vitro

Phychemistry, Phytochemical, Pharmacological and Molecular Study of Zingiber Officinale Roscoe: A Review

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