Ginger extract reduces delayed gastric emptying and nosocomial pneumonia in adult respiratory distress syndrome patients hospitalized in an intensive care unit

Shariatpanahi, Zahra Vahdat; Taleban, Fourogh Azam; Mokhtari, Majid; Shahbazi, Shaahin

doi:10.1016/j.jcrc.2009.12.008

Cited by 34 publications

(17 citation statements)

References 10 publications

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“…According to the presented data, 58 (6.9 %) of the hospitalized patients in ICU wards developed nosocomial pneumonia and 42 (10.2 %) out of 410 patients on ventilators developed VAP. A higher rate of VAP has been reported from Iran for adult patients suffering from respiratory distress syndrome [11], and similar rates were seen in Latin America, Asia, Africa and the United States [12,13]. Furthermore, another report from Iran has shown that additional hospital stays of patients could attribute to nosocomial infection [14].…”

Section: Discussionmentioning

confidence: 64%

Ventilator-associated pneumonia in Iranian intensive care units

Japoni

Vazin

Davarpanah

et al. 2011

J Infect Dev Ctries

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Introduction: Nosocomial pneumonia (NP) and ventilator associated pneumonia (VAP) occur most frequently in intensive care units (ICU). This study seeks to determine the etiological agents of NP and VAP along with their antibacterial susceptibility patterns, and to evaluate the factors contributing to patient mortality. The impact of appropriate therapy in terms of three parameters (body temperature, PaO2/FiO2 ratio and leukocyte count) was also assessed. Methodology: This study involved 836 adult patients admitted to ICUs at the Nemazee Hospital, Shiraz, Iran, over nine months during 2008 and 2009. The inclusion criterion was the commencement of infection at least 48 hours following hospital admission. Clinical parameters including core temperature, leukocyte count. and PaO2/FiO2 ratio were evaluated. Antibiotic sensitivities of the isolated bacteria to a panel of antibiotics were determined using E-test. Results: Of 836 cases, only 58 (6.9 %) cases of NP were diagnosed, of which 42 (72 %) were VAP. A. baumannii, MRSA, P. aeruginosa and MSSA were the most prevalent bacteria. Significant correlations between previous antibiotic therapy (p = 0.04), use of corticosteroids (p = 0.02) and attributable mortality were found. A strong correlation between fever abatement and the ratio of PaO2/FiO2 with responses to treatment and outcomes was also evident. Conclusions: Combined treatment with meropenem/imipenem, ciprofloxacin and vancomycin seems to be appropriate and could cover all possible infective agents. To reduce mortality rate, reasonable prescription of antibiotics and corticosteroids could be effective. Furthermore, adopting a strategy to reduce body temperature and PaO2/FiO2 ratio could be beneficial in patients' outcomes.

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Section: Discussionmentioning

confidence: 64%

Ventilator-associated pneumonia in Iranian intensive care units

Japoni

Vazin

Davarpanah

et al. 2011

J Infect Dev Ctries

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“…Generally, a higher rate of VAP has been reported in Iran (29,(37)(38)(39)(40). Notably, similar rates have been revealed in Latin America, Asia, Africa, and the United States (41,42).…”

Section: Discussionmentioning

confidence: 56%

Is Serum Lactate Level a Prognostic Factor for the Incidence and Mortality of Ventilator-Associated Pneumonia Among Poisoned ICU-Admitted Patients?

Mozafari

Mortazavi

Alinia

et al. 2016

Iran Red Crescent Med J

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Background: Lactate level is known to increase among the majority of patients with toxicity. This study aimed to determine whether lactate level upon admission is higher among patients with ventilator-associated pneumonia (VAP). Objectives: We aimed to determine whether serum lactate level is associated with the increased risk of VAP in intensive care unit (ICU)-admitted patients with toxicity. Methods: This retrospective study was conducted in a training medical poisoning center in Iran, using convenience sampling. A total of 157 poisoned patients, aged ≥ 13 years, who were admitted to the ICU over the past seven months, were included in the study.Subjects were categorized into two groups, based on their VAP diagnosis (VAP-positive and non-VAP) and the outcomes (surviving or non-surviving). The VAP-positive patients were compared with others with regard to the mean level of serum lactate level upon admission. Additionally, non-surviving patients were compared with their surviving counterparts. Results: Overall, 71 (45.2 %) VAS-positive cases were reported, in addition to 36 cases of mortality. Alkaline phosphatase (ALP) was the most common toxic agent (36%), followed by methanol. Significant differences were noted between the groups in terms of Simplified Acute Physiology Score-II (SAPS-II), Glasgow Coma Scale (GCS) score, length of ICU stay, and percentage of ventilation process.The mean levels of lactate at admission were 3.71 ± 3.35 and 4.19 ± 4.09 among VAP-positive and non-VAP patients, respectively; the difference was not statistically significant. Also, non-surviving patients had a longer ICU stay (12.20 days), compared to surviving patients (5.39) (P = 0.008). Moreover, admission lactate level was 7.06 ± 5.29 mmol/L among non-surviving patients and 3.01 ± 2.53 among surviving cases (P < 0.001). Conclusions: Based on the findings, the mortality rate was 22.9% among poisoned patients with an elevated serum lactate level. We can conclude that mortality is associated with toxicants, but not the occurrence of VAP; in fact, VAP scenarios do not elevate serum lactate level.

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“…Ginger has been recognized as having a digestive stimulant action 1-5. We had proven the enhanced gastric motility with ginger in normal volunteers and patients suffering from functional dyspepsia.…”

Section: Discussionmentioning

confidence: 80%

“…Ginger ( Zingiber officinale ) has been used to treat a number of diseases; including those affecting the digestive tract 1-5. It has been a household remedy for dyspepsia, flatulence, colic and diarrhea, as well as being used in foods as a spice.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Ginger on Gallbladder Motility in Healthy Male Humans

Chuah

Wu²,

Tai³

et al. 2011

J Neurogastroenterol Motil

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Background/AimsGinger has been used to treat a number of diseases including those affecting the digestive tract. This study was aimed to investigate the effects of ginger on gallbladder volume and gastrointestinal sensation in healthy male subjects.MethodsNineteen healthy male volunteers (age 21.3 ± 3.9 years, body mass index 21.6 ± 1.9 kg/m2) were studied on 2 occasions in a double blind randomized crossover design. After ingesting ginger (1,200 mg) or placebo capsules (starch), abdominal ultrasound was used to measure the gallbladder volume (calculated from gallbladder width, depth and diameter) and ejection fraction following a standard test meal. Gastrointestinal symptoms were also recorded at regular intervals by visual analogue scales.ResultsThere were no differences in gallbladder volume or ejection fraction between ginger and placebo. Abdominal symptoms of bloating, fullness, nausea, discomfort and hunger was not different between the 2 occasions.ConclusionsGinger (1,200 mg) may not affect gallbladder ejection fraction and possible relevant abdominal symptoms in healthy male human subjects.

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Ginger extract reduces delayed gastric emptying and nosocomial pneumonia in adult respiratory distress syndrome patients hospitalized in an intensive care unit

Cited by 34 publications

References 10 publications

Ventilator-associated pneumonia in Iranian intensive care units

Ventilator-associated pneumonia in Iranian intensive care units

Is Serum Lactate Level a Prognostic Factor for the Incidence and Mortality of Ventilator-Associated Pneumonia Among Poisoned ICU-Admitted Patients?

The Effects of Ginger on Gallbladder Motility in Healthy Male Humans

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