Ginger extract extends the lifespan of Drosophila melanogaster through antioxidation and ameliorating metabolic dysfunction

Zhou, Yuzhi; Xue, Li-Ying; Gao, Li; Qin, Xuemei; Du, Guanhua

doi:10.1016/j.jff.2018.08.040

Cited by 25 publications

(19 citation statements)

References 62 publications

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“…Similar results have been reported in Drosophila after exposure to silver nanoparticles and cerium (a rare element that can produce oxidative damage); these events have been attributed to oxidative stress processes (Ahamed et al, 2010;Huang et al, 2010). Conversely, a diet that includes antioxidants has been found to extend lifespan and reduce signs of aging in Drosophila (Peng et al, 2012;Wang et al, 2015;Zhou et al, 2018). In previous studies, toxic effects of metal nanoparticles alters the lifespan of some insects (Jiang et al, 2015;Mehta et al, 2009;Small et al, 2016), for example in Blatella germanica, gold nanoparticles produces a sublethal effect on larval viability and lifespan reduction.…”

Section: Discussionsupporting

confidence: 71%

“…In Drosophila, lifespan can be determined by genetic factors (Kimber and Chippindale, 2013;Zhou et al, 2018) but also by dietary nutrients (Hoedjes et al, 2017). Our results demonstrate that oral exposure to Ch-Fe3O4NPs shortened mean and maximum lifespan, reduced larval survival, produce DNA damage and increased hemocytes number.…”

Section: Discussionmentioning

confidence: 68%

“…Also, the hemocytes are suitable cells to detect the DNA damage through the comet assay (Alaraby et al, 2015;Carmona et al, 2015b;Gajski et al, 2019). Lifespan of Drosophila could be critically influenced by the components of food, for example, the presence of iron in the diet produce accumulation of iron, shortening lifespan and senescence in the flies (Massie et al, 1985), while carotenoids, some amino acids and proteins prolong the lifespan due to their antioxidant action (Hoedjes et al, 2017;Zhang et al, 2014;Zhou et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the Toxic Effects of Chitosan-Coated Magnetite Nanoparticles on Drosophila melanogaster

Vela¹,

J²,

Cárdenas³

et al. 2020

American Journal of Applied Sciences

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Nanoparticles are a cause for concern because of their potential toxic effects on human health and the environment. The aim of this study was to assess the toxic effect of chitosan-coated magnetite nanoparticles (11.00±4.7 nm) on Drosophila melanogaster through the observation of hemolymph composition, DNA damage, larval survival and lifespan of flies. Chitosan-coated magnetite nanoparticles were synthesized by coprecipitation method. Drosophila larvaes and adults were exposed to 500 and 1000 ppm nanoparticles solution. After exposure, each type of larval hemocytes was recognized. Comet assay was performed to detect the DNA damage in the hemocytes. Also, the larval survival and lifespan of exposed flies were observed. Our results showed the toxic effect of the chitosan-coated magnetite nanoparticles through the increment of hemocytes, the emergence of lamellocytes, the presence of apoptotic hemocytes and the DNA damage detected by comet assay. In addition, nanoparticles produce decreasing of larval survival and shortening of the mean and maximum lifespan. The toxic effect the chitosan-coated magnetite nanoparticles is directly associated with 1000 ppm. No DNA damage was observed at 500 ppm.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of the Toxic Effects of Chitosan-Coated Magnetite Nanoparticles on Drosophila melanogaster

Vela¹,

J²,

Cárdenas³

et al. 2020

American Journal of Applied Sciences

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“…Fly lifespan reduces when flies are reared on yeast extract instead of lyophilized whole brewer's yeast (Bass et al 2007a). Male fruit flies treated with ginger extract at 2 mg/ml increased the mean lifespan from 37 to 40 days compared with control flies (Zhou et al 2018). Male fruit flies fed with cranberry anthocyanin extract at 20 mg/ml for 81 days increased the mean lifespan from 48 to 53 days compared with control flies (Wang et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Ellagic acid prolongs the lifespan of Drosophila melanogaster

et al. 2019

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Wild-type CantonS flies of Drosophila melanogaster were treated with ellagic acid at 100 μM and 200 μM concentrations. Longevity assay showed male flies fed with 200 μM ellagic acid displayed longer mean lifespan and maximum lifespan than control flies. Female flies fed with 200 μM ellagic acid laid less number of eggs than control. The eclosion time was less in female flies fed with 200 μM ellagic acid. Ellagic acid fed female flies performed better than male flies and control flies for heat shock tolerance and starvation stress. Male flies treated with 100 μM ellagic acid recovered faster from cold shock compared with control flies. Male and female flies treated with ellagic acid displayed increased survival following exposure to 5% hydrogen peroxide. Gene expression studies displayed upregulated expressions of CAT, dFOXO, ATG1, and SOD2 in ellagic acid-treated male flies, and upregulated expressions of dFOXO, CAT, and SOD2 in ellagic acidtreated female flies. Results from these studies show the pro-longevity effect of ellagic acid on Drosophila melanogaster.

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“…The target genes were copper zinc superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD), catalase (CAT), glutamate-cysteine ligase catalytic subunit (GclC), cap-n-collar (cnc), methuselah (MTH), Keap1, and deacetylase sir2 (dSir2). The rp49 transcript was used as the reference for quantifying the relative transcript level of each selected gene (Yu-zhi, Li-ying, Li, Xue-mei, & Guan-hua, 2018). The primers used to amplify the target genes are shown in Table 1.…”

Section: Mrna Expression Assaymentioning

confidence: 99%

Apple phlorizin attenuates oxidative stress inDrosophila melanogaster

et al. 2018

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Apple phlorizin has a lot of applications owing to its antioxidant and hepatoprotective properties. This study explored the antioxidant effects and life span‐prolonging activity of apple phlorizin in Drosophila melanogaster. Treatment with apple phlorizin was found to significantly extend the life span and ameliorate the age‐related decline of locomotor function. This life span‐extending activity was associated with the increased activity of superoxide dismutase, catalase, mRNA expression of glutamate–cysteine ligase catalytic subunit, cap‐n‐collar (cnc, homologue of mammalian Nrf2 gene), Keap1, and deacetylase sir2, as well as the downregulation of methuselah. Computational analysis suggested phlorizin could work as a Nrf2 activator and exert its biological activities by interfering with the Keap1 and Nrf2 binding. Therefore, it was concluded that the antioxidant and anti‐aging effects of phlorizin might, at least in part, be mediated through the cooperation with the endogenous stress defense system. Practical applications Phlorizin, from apple peel, has been used as a nutrient for over 100 years. To date, despite extensive research on phlorizin, a report on its effect on the antioxidant system in fruit flies is yet lacking. This report demonstrates that phlorizin can exert a protective effect on antioxidant issues and prolong life in fruit flies, which is valuable in the rational utilization of phlorizin in functional foods.

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Ginger extract extends the lifespan of Drosophila melanogaster through antioxidation and ameliorating metabolic dysfunction

Cited by 25 publications

References 62 publications

Assessment of the Toxic Effects of Chitosan-Coated Magnetite Nanoparticles on Drosophila melanogaster

Assessment of the Toxic Effects of Chitosan-Coated Magnetite Nanoparticles on Drosophila melanogaster

Ellagic acid prolongs the lifespan of Drosophila melanogaster

Apple phlorizin attenuates oxidative stress inDrosophila melanogaster

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