Ginger extract ameliorates bisphenol A (BPA)-induced disruption in thyroid hormones synthesis and metabolism: Involvement of Nrf-2/HO-1 pathway

Mohammed, Eman; Hashem, Khalid S.; Ahmed, Amr E.; Aly, Mohamed Tarek; Aleya, Lotfi; Abdel-Daim, Mohamed M.

doi:10.1016/j.scitotenv.2019.134664

Cited by 74 publications

(37 citation statements)

References 72 publications

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“…al., 2015; Mohammed et. al., 2019), and it has been shown to have antimicrobial properties. Gingerol is converted to shogaol and zingerone which are less potent in dried ginger and may account for the elevated growth of the fungi in the dried ginger extract as compared to growth in the fresh extract.…”

Section: Resultsmentioning

confidence: 99%

“…The main nutraceutical of functional significance in fresh ginger is gingerol (Cho et. al., 2015;Mohammed et. al., 2019), and it has been shown to have antimicrobial properties.…”

Section: Vegetative Growth Of Selected Fungi In the Ginger Extractmentioning

confidence: 99%

“…Spices and culinary herbs have always been part of the diet since ancient times, and indeed have been a major part of merchandize during early global trade and voyages. With the increasing awareness of the association between dietary phytochemicals and human health and well-being, spices and culinary herbs have gained the attention of the scientific community because they contain chemical compounds that possess antioxidants and medicinal properties (Jeswal & Kumar, 2015;Madsen et al, 1995;Mohammed et. al., 2019;Sharma et.…”

Section: Introductionmentioning

confidence: 99%

“…Ginger ( Zingiber officinale Roscoe) is the rhizome of the Zingiberaceae family used as a spice and herbal medicine (FAO, 2002; Gupta & Tennyson, 2020; Mohammed et. al., 2019). It can be obtained worldwide in its fresh or semiprocessed form.…”

Section: Introductionmentioning

confidence: 99%

“…With the increasing awareness of the association between dietary phytochemicals and human health and well‐being, spices and culinary herbs have gained the attention of the scientific community because they contain chemical compounds that possess antioxidants and medicinal properties (Jeswal & Kumar, 2015; Madsen et al, 1995; Mohammed et. al., 2019; Sharma et. al., 2017).…”

Section: Introductionmentioning

confidence: 99%

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The effect of vinegar and drying (Solar and Open Sun) on the microbiological quality of ginger (ZINGIBER OFFICINALE ROSCOE) rhizomes

Amoah

Kalakandan

Wireko‐Manu

et al. 2020

Food Science & Nutrition

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show abstract

Section: Resultsmentioning

confidence: 99%

“…The main nutraceutical of functional significance in fresh ginger is gingerol (Cho et. al., 2015;Mohammed et. al., 2019), and it has been shown to have antimicrobial properties.…”

Section: Vegetative Growth Of Selected Fungi In the Ginger Extractmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The effect of vinegar and drying (Solar and Open Sun) on the microbiological quality of ginger (ZINGIBER OFFICINALE ROSCOE) rhizomes

Amoah

Kalakandan

Wireko‐Manu

et al. 2020

Food Science & Nutrition

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Bisphenol A exposure induces testicular oxidative damage via FTO/m6A/Nrf2 axis during postnatal development in mice

Ling

Huang

et al. 2023

J of Applied Toxicology

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Bisphenol A (BPA), a commonly used plasticizer in the production of polycarbonate plastics and epoxy resins, has been shown to induce male reproductive toxicity. However, the effects of BPA exposure on early testicular development have not been thoroughly studied, and the underlying mechanism is yet to be elucidated. In the current study, neonatal male mice were exposed to BPA at 0, 0.1, and 5 mg/kg, respectively, by daily subcutaneous injection during postnatal day (PND) 1–35 to explore its effects on testicular development at PND 36 (the end of the first round of spermatogenesis). Morphological analyses showed that BPA exposure significantly induced apoptosis of testicular cells (p < 0.01 and p < 0.001) and reduced the thickness of seminiferous epithelium (p < 0.01). In addition, BPA exposure significantly decreased the total antioxidant capacity of testes and levels of transcription factor Nrf2 as well as its downstream antioxidant molecules of NQO1 and GPx‐1 (p < 0.05 and p < 0.01). Furthermore, global m6A modifications of mRNAs were upregulated accompanied by declined m6A demethylase (FTO) in the testes of BPA groups (p < 0.05 and p < 0.01). MeRIP‐quantitative real‐time polymerase chain reaction (qPCR) demonstrated that BPA exposure markedly increased the m6A modification of Nrf2 mRNA (p < 0.05 and p < 0.01). These findings suggest that upregulation of m6A induced by inhibited FTO may be involved in BPA‐induced testicular oxidative stress and developmental injury during postnatal development, which provides a new idea to reveal the mechanism underlying BPA interfering with testicular development.

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Impacts of Plasticizers on Riverine Ecological Integrity in Context to Sustainability Challenges

Aslam

Qadir

Ahmad

et al. 2022

Emerging Contaminants and Associated Treatment Technologies

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Ginger extract ameliorates bisphenol A (BPA)-induced disruption in thyroid hormones synthesis and metabolism: Involvement of Nrf-2/HO-1 pathway

Cited by 74 publications

References 72 publications

The effect of vinegar and drying (Solar and Open Sun) on the microbiological quality of ginger (ZINGIBER OFFICINALE ROSCOE) rhizomes

The effect of vinegar and drying (Solar and Open Sun) on the microbiological quality of ginger (ZINGIBER OFFICINALE ROSCOE) rhizomes

Bisphenol A exposure induces testicular oxidative damage via FTO/m6A/Nrf2 axis during postnatal development in mice

Impacts of Plasticizers on Riverine Ecological Integrity in Context to Sustainability Challenges

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