Ginger as an Antiemetic Modality for Chemotherapy-Induced Nausea and Vomiting: A Systematic Review and Meta-Analysis

Abstract

Although ginger is known as a traditional antiemetic, current evidence does not support the effect of ginger in CINV control. The findings of this study inform healthcare providers that its effectiveness remains to be established from methodologically rigorous future trials.

Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7

“…To date, the effectiveness of ginger in controlling nausea remains controversial. Ginger is superior to placebo in treating nausea in several studies,[10,11] whereas its effects are not significant in other studies [12,13]…”

“…Ginger is superior to placebo in treating nausea in several studies, [10,11] whereas its effects are not significant in other studies. [12,13] Gingerols (e.g. 6-, 8-and 10-gingerol; Figure 1) are the principal pungent constituents of ginger with many types of pharmacological effects, such as antitumour-promoting activity.…”

Is ginger beneficial for nausea and vomiting? An update of the literature

“…Lee and Oh [8] performed a meta-analysis of included studies and while no effect on incidence of acute nausea and vomiting, and severity of acute nausea was reported, only two to three studies were included per analyses which limits the strength of these conclusions.…”

Integrative Medicine for Gastrointestinal Disease

“…70 A meta-analysis in chemotherapy-induced nausea and vomiting found no significant difference in the incidence and severity of nausea and vomiting in the ginger groups versus placebo or metoclopramide. 71 These results are difficult to interpret as there were only 5 trials and comparison groups included both placebo and active control. Overall, ginger is likely effective for a variety of conditions producing nausea.…”