GINA updated 2019

Hogan, Angela Duff; Bernstein, Jonathan A.

doi:10.1016/j.anai.2019.11.005

Cited by 25 publications

(14 citation statements)

References 5 publications

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“…During the maintenance period, Dermatophagoides Farinae Drops of bottles 4 were used and 3 drops/day were maintained until the end of the treatment. During the treatment of SLIT, other drugs for asthma and rhinitis were used according to the clinical symptoms of the children according to the guidelines [ 6 , 15 ].…”

Section: Methodsmentioning

confidence: 99%

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Effects of Sublingual Duster Mite Drops on Lung Function and Exhaled Nitric Oxide in Children with Multiple and Single Allergic Respiratory Diseases

Wang

Luo

et al. 2020

Canadian Respiratory Journal

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Objective. To evaluate the efficiency of sublingual immunotherapy with Dermatophagoides Farinae Drops in children with single and multiple respiratory allergic diseases. Methods. Seventy-one children with allergic respiratory diseases who had been treated with Dermatophagoides Farinae Drops for one year or more were divided into a single allergic group (12 cases) and multiple allergic group (59 cases). The rhinitis score, daytime and night symptom score of asthma, VAS score, drug score, pulmonary function, and FeNO level before and after treatment were evaluated and compared between the two groups. Results. The rhinitis score, night symptom score, VAS score, and drug score in the single allergic group after treatment were significantly lower than those before treatment ( p < 0.05 ), but there was no significant difference in the daytime symptom score before and after treatment ( p > 0.05 ). The rhinitis score, VAS score, and drug score in the multiple allergic group after treatment were significantly lower than those before treatment ( p < 0.05 ), but there was no significant difference in the scores of daytime symptoms and nighttime symptoms before and after treatment ( p > 0.05 ). In both the single allergic group and multiple allergic group, the pulmonary function indexes of the patients were significantly improved after treatment, and the FeNO after treatment was significantly lower than that before treatment ( p < 0.05 ). There was no significant difference in scores, pulmonary function, and FeNO between the two groups ( p > 0.05 ). Conclusion. Sublingual specific immunotherapy is effective in treating multiple and single allergic respiratory diseases in children.

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Section: Methodsmentioning

confidence: 99%

“…Symptomatic treatment is based on antihistamines and corticosteroids. Allergic asthma is characterized by chronic inflammation which results in recurrent attacks of cough, wheezing, sometimes chest tightness, and variable airflow obstruction [ 5 , 6 ]. It is a major public health problem affecting over 300 million people worldwide.…”

Section: Introductionmentioning

confidence: 99%

Effects of Sublingual Duster Mite Drops on Lung Function and Exhaled Nitric Oxide in Children with Multiple and Single Allergic Respiratory Diseases

Wang

Luo

et al. 2020

Canadian Respiratory Journal

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“…Taking into account the pilot character of the current study, it is useful to estimate the sample size necessary for validating of the found peculiarities. The sample size N can be crudely estimated using the known formula N = 2 • (Z α +Z β ) 2 /(d/SD) 2 , where Z α and Z β are the normal distribution values at the levels of type I and II error probabilities of α/2 and β, respectively; d/SD is the required (clinically-significant) ratio between the group mean value difference (d) and their standard deviations (SD). Using the typical values of α = 0.05 for 95% confidence level and β = 0.80 for criterion power level, Z α and Z β values are 1.96 and 0.84, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Bronchial asthma (BA) is a chronic inflammatory disease of the respiratory tract, the leading clinical manifestations of which are reversible bronchoconstriction and bronchial hyperreactivity (1)(2)(3). The goal of BA therapy at this stage is achieving control over symptoms and risk factors of exacerbation of the disease (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Bronchial Patency and Parameters of ECG Supraventricular Component in Children With Bronchial Asthma

Gordina¹,

Egoshina²,

Eliseeva³

et al. 2020

Front. Pediatr.

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Background: Uncontrolled asthma (BA) can be complicated by cardiac conduction disturbances and arrhythmias. It is typical mainly for adult asthmatics patients. In asthmatics children the effect of bronchoconstriction on cardiac conduction, including the supraventricular component of the ECG, is currently under discussion. The objective of the research is to analyze ECG parameters of the atrial complex and atrioventricular conduction and to assess their relationship with spirometric indicators in children with BA. Methods: Hundred three patients with BA from the age of 6-17 years were examined. The spirometric parameters were evaluated, including the Tiffeneau index (TI): FEV1/FVC (%), according to the level of which the patient groups were distinguished. Group 1 (G1): with TI more than 85%, (n = 15); Group 2 (G2): with TI from 85 to 75%, (n = 40); Group 3 (G3): with TI <75%, (n = 48). The ECG parameters that characterize supraventricular conduction, including the PQ interval (sec) and the sPQ segment (sec), were analyzed. We had calculated relative PQ (rPQ) by the formula rPQ=PQ/PQmed, where PQ is the patient's PQ, PQmed are the median PQ values of healthy children of age selected. Results: The duration of the PQ in groups G1 and G2 was 0.13 (0.11; 0.14) s; and 0.13 (0.12; 0.14) s, respectively, which is statistically significantly less than in patients of groups G3-0.14 (0.13; 0.15] s, p = 0.01. The duration of the sPQ segment in children of groups G1 and G2 was also generally shorter than in patients of groups G3, and amounted, respectively, to 0.05 (0.04; 0.06) s, 0.04 (0.04; 0.05) s, and 0.06 (0.04; 0.07) s, p = 0.02. The rPQ increased progressively as TI decreased and amounted in G1 to 92.9 (85.7; 106.3) %, in G2 100.0 (92.9; 103.0) %, and in G3 104 (100.0; 107.7) %, p = 0.009. A statistically significant negative correlation between IT and PQ-r = −0.23, p = 0.02; with sPQ-r = −0.20, p = 0.045; and with rPQ-r = −0.25, p = 0.01 was revealed. Conclusion: A decrease in TI in asthmatics children is associated with a prolongation of the PQ. This may indicate a slowdown in supraventricular conduction in patients with uncontrolled asthma and, thus, be considered as a risk for the formation of subsequent supraventricular arrhythmias.

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“…Bronchial asthma (BA) is the most common chronic respiratory disease in children characterized by bronchial hypersensitivity in combination with variable bronchial obstruction. Currently, the goal of the treatment of this disease is to achieve control over the symptoms and risk factors for exacerbation of the disease (1,2). This is realized by the basic anti-inflammatory therapy since the most significant component of the pathogenesis is chronic inflammation localized in the respiratory tract and occurring in childhood mainly by the Th2-dependent mechanism (3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Indicators of Nasal Respiratory Function and Spirometric Parameters in Children With Bronchial Asthma

et al. 2021

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Introduction: The relationship between objective indicators of nasal obstruction and airflow limitation in children with bronchial asthma (BA) and allergic rhinitis (AR) has not yet been studied.Objective: To study the relationship between objective parameters of nasal obstruction and airflow limitation, determined using the methods of anterior active rhinomanometry (AARM) and spirometry in children with BA and AR.Materials and Methods: Eighty eight children and adolescents with BA and AR, boys−65.9% (58/88), were examined. The median age was 11.09 [10.42; 11.76] years. To determine airflow limitation, the following spirometric parameters were evaluated: forced vital capacity of the lungs (FVC), forced expiratory volume in 1 s (FEV1), the ratio of FEV1/FVC, and maximum expiratory flow at the point 25% of the flow-volume loop (MEF25). Data were recorded both in absolute values and in relative units (% pred). Nasal respiratory function was determined by AARM based on the total nasal airflow (TNAF) in absolute (Pa/cm3/s) and relative units (RTNAF, % pred).Results: In the general cohort and in boys but not in girls, a statistically significant direct correlation was found between TNAF (Pa/cm3/s) and absolute spirometry parameters of bronchial patency—all had p < 0.01. Also, RTNAF and relative MEF25 values (% pred) in the general cohort were R = 0.22, p = 0.04, and in boys, R = 0.28, p = 0.03. In girls, there was no statistically significant correlation between nasal respiratory function and spirometric parameters, all p > 0.05. Additional analysis of literature was conducted to ascertain that the identified gender differences were not occasional.Conclusion: The significant positive correlation of absolute values of AARM and spirometric parameters in children with BA and AR was established, which apparently reflects the physical development of children. Of all the relative indicators of spirometry, only MEF25 (% pred), which indirectly reflects the patency of small bronchi, had a distinct direct correlation with RTNAF. These patterns are clearly expressed in boys with BA. In girls with this disease, however, the relationship between nasal respiratory function and spirometric indicators seems to be more complex and requires further study.

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GINA updated 2019

Cited by 25 publications

References 5 publications

Effects of Sublingual Duster Mite Drops on Lung Function and Exhaled Nitric Oxide in Children with Multiple and Single Allergic Respiratory Diseases

Effects of Sublingual Duster Mite Drops on Lung Function and Exhaled Nitric Oxide in Children with Multiple and Single Allergic Respiratory Diseases

The Relationship Between Bronchial Patency and Parameters of ECG Supraventricular Component in Children With Bronchial Asthma

The Relationship Between Indicators of Nasal Respiratory Function and Spirometric Parameters in Children With Bronchial Asthma

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