GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo

Webb, Louise M. C.; Datta, Preeta; Bell, Sarah E.; Kitamura, Daisuke; Turner, Martin; Butcher, Geoffrey W.

doi:10.4049/jimmunol.1501582

Cited by 26 publications

(24 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding may explain the lack of autoimmunity observed in the Gimap1 f/f CD2Cre + strain of mice and suggests that, despite their structural similarities, GIMAP1 and GIMAP5 perform discrete functions in T cells. In recent work we have looked at the effect of GIMAP1 deletion in B cells and also find that both resting and activated B cells depend on GIMAP1 for their survival . Interestingly, attrition in the T‐cell compartments of GIMAP5‐deficient mice is aggravated as the animals age .…”

Section: Discussionmentioning

confidence: 99%

Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice

et al. 2016

Self Cite

View full text Add to dashboard Cite

An effective immune system depends upon the survival of mature T cells in the periphery. Members of the GIMAP family of GTPases have been proposed to regulate this homeostasis, supported by the paucity of peripheral T cells in rodents deficient for either GIMAP1 or GIMAP5. It is unclear whether this lack of T cells is a consequence of an ontological defect, causing the thymus to generate and export T cells incapable of surviving in the periphery, or whether (alternatively or additionally) mature T cells intrinsically require GIMAP1 for survival. Using the ERT2Cre+ transgene, we conditionally deleted Gimap1 in C57BL/6 mice and demonstrate that GIMAP1 is intrinsically required for the survival of mature T cells in the periphery. We show that, in contrast to GIMAP5, this requirement is independent of the T‐cells' activation status. We investigated the nature of the survival defect in GIMAP1‐deficient CD4+ T cells and show that the death occurring after GIMAP1 ablation is accompanied by mitochondrial depolarization and activation of the extrinsic apoptotic pathway. This study shows that GIMAP1 is critical for maintaining the peripheral T‐cell pool in mice and offers a potent target for the treatment of T‐cell‐mediated diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Slamf 7 regulates differentiation of various lymphocyte lineages. Gimaps are essential for survival of naïve and activated B-and T-cells 44,45 . Several genes indicated higher activity of B-cells in H-gEBV.…”

Section: Differential Gene Expression 4 Weeks Post-challenge Many Immentioning

confidence: 99%

Response of the Salmon Heart Transcriptome to Pancreas Disease: Differences Between High- and Low-Ranking Families for Resistance

Robinson

Krasnov

Burgerhout

et al. 2020

Sci Rep

View full text Add to dashboard Cite

pancreas disease caused by salmonid alphaviruses leads to severe losses in Atlantic salmon aquaculture. The aim of our study was to gain a better understanding of the biological differences between salmon with high and low genomic breeding values (H-gEBV and L-gEBV respectively) for pancreas disease resistance. Fish from Hand L-gEBV families were challenged by intraperitoneal injection of salmonid alphavirus or co-habitation with infected fish. Mortality was higher with co-habitation than injection, and for L-than H-gEBV. Heart for RNA-seq and histopathology was collected before challenge and at four-and ten-weeks post-challenge. Heart damage was less severe in injection-challenged H-than L-gEBV fish at week 4. Viral load was lower in H-than L-gEBV salmon after co-habitant challenge. Gene expression differences between Hand L-gEBV manifested before challenge, peaked at week 4, and moderated by week 10. At week 4, H-gEBV salmon showed lower expression of innate antiviral defence genes, stimulation of Band T-cell immune function, and weaker stress responses. Retarded resolution of the disease explains the higher expression of immune genes in L-gEBV at week 10. Results suggest earlier mobilization of acquired immunity better protects H-gEBV salmon by accelerating clearance of the virus and resolution of the disease.

show abstract

“…GIMAPs are involved in the development, maintenance, and homeostasis of lymphocytes, especially CD4 + T cells and B cells, but also T regulatory cells (Tregs) (53)(54)(55). In the absence of individual GIMAP members, there is progressive lymphocyte loss leading to lymphopenia, poor cell proliferation, and paradoxical autoimmune states because of impaired Treg function (54)(55)(56)(57)(58). A previous gene family analysis showed that the GIMAP family is expanded in the Egyptian rousette compared to a bat ancestor (19), with 14 putative members.…”

Section: Discussionmentioning

confidence: 99%

Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells

et al. 2020

View full text Add to dashboard Cite

Bats host a number of viruses that cause severe disease in humans without experiencing overt symptoms of disease themselves. While the mechanisms underlying this ability to avoid sickness are not known, deep sequencing studies of bat genomes have uncovered genetic adaptations that may have functional importance in the antiviral response of these animals. Egyptian rousette bats (Rousettus aegyptiacus) are the natural reservoir hosts of Marburg virus (MARV). In contrast to humans, these bats do not become sick when infected with MARV. A striking difference to the human genome is that Egyptian rousettes have an expanded repertoire of IFNW genes. To probe the biological implications of this expansion, we synthesized IFN-ω4 and IFN-ω9 proteins and tested their antiviral activity in Egyptian rousette cells. Both IFN-ω4 and IFN-ω9 showed antiviral activity against RNA viruses, including MARV, with IFN-ω9 being more efficient than IFN-ω4. Using RNA-Seq, we examined the transcriptional response induced by each protein. Although the sets of genes induced by the two IFNs were largely overlapping, IFN-ω9 induced a more rapid and intense response than did IFN-ω4. About 13% of genes induced by IFN-ω treatment are not found in the Interferome or other ISG databases, indicating that they may be uniquely IFN-responsive in this bat.

show abstract

GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo

Cited by 26 publications

References 62 publications

Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice

Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice

Response of the Salmon Heart Transcriptome to Pancreas Disease: Differences Between High- and Low-Ranking Families for Resistance

Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells

Contact Info

Product

Resources

About