Gilles de la Tourette syndrome

Wassman, E. Robert; Eldridge, Roswell; Abuzzahab, F. S.; Nee, Linda E.

doi:10.1212/wnl.28.3.304

Cited by 44 publications

(9 citation statements)

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“…In 12 of 13 Jewish families, there were multiple members with motor and vocal tics. Wassman et al (1978) replicated this study in Minneapolis and found 13 out of 14 families affected.…”

Section: Genetic and Neurochemical Stagesupporting

confidence: 68%

Extraordinary Disorders of Human Behavior

Friedmann¹,

Faguet²

1982

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“…In 12 of 13 Jewish families, there were multiple members with motor and vocal tics. Wassman et al (1978) replicated this study in Minneapolis and found 13 out of 14 families affected.…”

Section: Genetic and Neurochemical Stagesupporting

confidence: 68%

Extraordinary Disorders of Human Behavior

Friedmann¹,

Faguet²

1982

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“…Frontal lobe operations have included prefrontal lobotomies 37,42 and bimedial frontal leukotomies. 5,27 The limbic system was targeted during limbic leukotomy 32,34 and cingulotomy 4,20,21 with or without hypothalamotomy.…”

Section: Discussionmentioning

confidence: 99%

Chronic bilateral thalamic stimulation: a new therapeutic approach in intractable Tourette syndrome

Visser‐Vandewalle

Temel²,

Boon³

et al. 2003

Journal of Neurosurgery

251

185

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Based on the results of thalamotomies described by Hassler in 1970, the authors performed bilateral thalamic high-frequency stimulation (HFS) in three patients with intractable Tourette syndrome (TS). In this report they describe the long-term effects. Three male patients (42, 28, and 45 years of age) had manifested motor and vocal tics since early childhood. The diagnosis of TS was made according to the criteria of the Tourette Syndrome Classification Study Group. Any drug or alternative treatment had been either ineffective or only temporarily effective in all three patients. There was no serious comorbidity. The target for stimulation was chosen at the level of the centromedian nucleus, substantia periventricularis, and nucleus ventrooralis internus. After 2 weeks of test stimulation, the pulse generators were implanted. After a follow-up period of 5 years in the patient in Case 1, 1 year in the patient in Case 2, and 8 months in the patient in Case 3, all major motor and vocal tics had disappeared and no serious complications had occurred. When stimulation was applied at the voltage necessary to achieve an optimal result on the tics, a slight sedative effect was noted in all three patients. In the patients in Cases 1 and 3 there were stimulation-induced changes in sexual behavior. Chronic thalamic HFS may be an effective and safe treatment for medically intractable TS in adult patients. Unwanted stimulation-induced side effects may occur.

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“…Sustained improvement of 60-90% of patients has been reported in reviews of the literature and clinical reports, and about a dozen single-and double-blind studies of single patients also report positive results for haloperidol (Abuzzahab and Anderson, 1973;Bruun et al, 1976;Golden, 1977;Nee et al, 1980;Nomura and Segawa, 1979;Shapiro et al, 1978;Wassman et al, 1977). Well-controlled, comparative, crossover and double-blind studies (Abuzzahab and Anderson, 1973;Shapiro, , 1978Shapiro and Morris, 1978;Shapiro et al, 1978) have not been done, and some clinicians describe less favorable results (Cohen et al, 1980;Tibbetts, 1981).…”

mentioning

confidence: 97%