Gilboa Functional Test

Gilboa, Yafit

doi:10.1037/t67183-000

Cited by 3 publications

(3 citation statements)

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“…In fact, the first aptamer-based therapy, pegaptanib (Macugen), was approved by the U.S. Food and Drug Administration (FDA) in 2004 for the treatment of age-related macular degeneration. 18 Despite its initial success, Macugen was outcompeted by monoclonal antibody fragments, ranibizumab (Lucentis) and bevacizumab (Avastin), crediting a higher effectivity and lower cost, respectively. 19 Although antibodies are more developed and understood, synthetic aptamers have several advantages in comparison to antibodies such as time and control over production together with the flexibility of designs, which is probably one of the most important benefits of aptamer technology.…”

Section: Aptamers Versus Antibodiesmentioning

confidence: 99%

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology

et al. 2019

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Nucleic acids play a central role in all domains of life, either as genetic blueprints or as regulators of various biochemical pathways. The chemical makeup of ribonucleic acid (RNA) or deoxyribonucleic acid (DNA), generally represented by a sequence of four monomers, also provides precise instructions for folding and higher-order assembly of these biopolymers that, in turn, dictate biological functions. The sequence-based specific 3D structures of nucleic acids led to the development of the directed evolution of oligonucleotides, SELEX (systematic evolution of ligands by exponential enrichment), against a chosen target molecule. Among the variety of functions, selected oligonucleotides named aptamers also allow targeting of cell-specific receptors with antibody-like precision and can deliver functional RNAs without a transfection agent. The advancements in the field of customizable nucleic acid nanoparticles (NANPs) opened avenues for the design of nanoassemblies utilizing aptamers for triggering or blocking cell signaling pathways or using aptamer-receptor combinations to activate therapeutic functionalities. A recent selection of fluorescent aptamers enables real-time tracking of NANP formation and interactions. The aptamers are anticipated to contribute to the future development of technologies, enabling an efficient assembly of functional NANPs in mammalian cells or in vivo. These research topics are *

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Section: Aptamers Versus Antibodiesmentioning

confidence: 99%

Aptamers as Modular Components of Therapeutic Nucleic Acid Nanotechnology

et al. 2019

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“…In [58] Gilboa initiated the idea of a non-linear spectral decomposition of singular vectors by defining a spectrum based on the forward-scale space formulation of the TV model. He was able to show that this non-linear spectrum can be converted into the original signal via a linear inverse transform.…”

Section: Introductionmentioning

confidence: 99%

Inverse scale space decomposition

Schmidt¹,

Benning

Schönlieb

2018

Inverse Problems

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We investigate the inverse scale space flow as a decomposition method for decomposing data into generalised singular vectors. We show that the inverse scale space flow, based on convex and absolutely one-homogeneous regularisation functionals, can decompose data represented by the application of a forward operator to a linear combination of generalised singular vectors into its individual singular vectors. We verify that for this decomposition to hold true, two additional conditions on the singular vectors are sufficient: orthogonality in the data space and inclusion of partial sums of the subgradients of the singular vectors in the subdifferential of the regularisation functional at zero.We also address the converse question of when the inverse scale space flow returns a generalised singular vector given that the initial data is arbitrary (and therefore not necessarily in the range of the forward operator). We prove that the inverse scale space flow is guaranteed to return a singular vector if the data satisfies a novel dual singular vector condition.We conclude the paper with numerical results that validate the theoretical results and that demonstrate the importance of the additional conditions required to guarantee the decomposition result.

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“…A variety of systems have been developed over the past decades to improve the procedure of CT-and/or MRI-guided needle placement, ranging from simple passive aids to fully automated robots. 12 Exemplary systems providing only visual guidance for needle placement are the needle navigation systems ActiViews CT-Guide 13 and CAScination 14 CAS-ONE, and the laser reference systems Neorad 15 SimpliCT and Amedo 16 LNS. Systems providing physical needle guidance include the patient-mounted AprioMed 17 Seestar, the Light Puncture Robot 18 and Robopsy, 19 the table-mounted AcuBot, 20 INNOMOTION, 21 and iSYS Medizintechnik 22 iSYS1 and the floor-mounted Perfint 23 ROBIO and MAXIO and various articulated robotic arms.…”

Section: Introductionmentioning

confidence: 99%