2014
DOI: 10.1161/circresaha.114.301286
|View full text |Cite
|
Sign up to set email alerts
|

Gigantic Business

Abstract: With every heartbeat, our cardiomyocytes are exposed to variable degrees of stress and strain of both internal and external origin. The unique mechanical properties of these myocytes are determined by the sarcomeric cytoskeleton. The actin (thin) and myosin (thick) filaments of the sarcomere are mainly relevant for active force generation, whereas the titin filaments determine sarcomeric viscoelasticity. The giant protein titin, which is the focus of this review, has various roles beyond viscoelastic force gen… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

7
232
0

Year Published

2015
2015
2022
2022

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 288 publications
(255 citation statements)
references
References 166 publications
7
232
0
Order By: Relevance
“…The main intracellular determinant of passive tension of the contractile machinery is the titin molecule, spanning the half sarcomere (30). This protein has two isoforms in adult mammalian heart, a larger and more compliant N2BA isoform (ϳ3.3 MDa) and a smaller and stiffer N2B isoform (ϳ 3.0 MDa).…”
Section: Discussionmentioning
confidence: 99%
See 4 more Smart Citations
“…The main intracellular determinant of passive tension of the contractile machinery is the titin molecule, spanning the half sarcomere (30). This protein has two isoforms in adult mammalian heart, a larger and more compliant N2BA isoform (ϳ3.3 MDa) and a smaller and stiffer N2B isoform (ϳ 3.0 MDa).…”
Section: Discussionmentioning
confidence: 99%
“…The predominant titin isoform in adult rats is the N2B (11). Stiffness is modulated by titin isoform composition, degradation, oxidative modifications, and phosphorylation by various protein kinases (30) especially within the elastic I-band region at N2-Bus and PEVK domains (1, 17-22, 26, 45).…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations