Gibbon ape leukemia virus-Hall's Island: new strain of gibbon ape leukemia virus

Reitz, M. S.; Wong‐Staal, Flossie; Haseltine, William A.; Kleid, Dennis G.; Trainor, Cecelia D.; Gallagher, Robert E.; Gallo, Robert C.

doi:10.1128/jvi.29.1.395-400.1979

Cited by 26 publications

(6 citation statements)

References 24 publications

(12 reference statements)

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“…R-MuLV was grown in the chronically infected JIS-V9 cell line (29). A gibbon ape with acute lymphocytic leukemia from the Hall's Island colony near Bermuda was the source of GaLV-H (8,18). GaLV-H was isolated from the peripheral blood of the animal and was grown in leukemic leukocytes.…”

Section: Methodsmentioning

confidence: 99%

“…R-MuLV is an exogenously transmitted ecotropic virus of N,B-tropic host range infecting Mus musculus. GaLV-H is an exogenously transmitted virus, recently isolated from a gibbon ape with lymphocytic leukemia (8), which has been shown to be closely related (18) to other GaLV isolates and simian sarcoma-associated virus. R-MuLV and GaLV have been reported to show 20% nucleic acid homology by RNA-DNA hybridization (4).…”

mentioning

confidence: 99%

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5'-terminal nucleotide sequences of the Rauscher leukemia virus and gibbon ape leukemia virus genomes exhibit a high degree of correspondence

Lovinger¹,

Schochetman²

1979

J Virol

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The 5'-terminal regions of gibbon ape leukemia virus-Hall's Island and Rauscher murine leukemia virus have been completely sequenced. The chain length for the 5'-terminal region of Rauscher murine leukemia virus is 140 nucleotides, and that for gibbon ape leukemia virus-Hall's Island is 144 nucleotides. An alignment of the sequences maximizing the number of ocrrespondences with the minimum introduction of gaps shows 81% nucleotide matches. From the complementary RNA, secondary structures of this region have been proposed. These data demonstrate the conservation of the 5'-terminal genetic sequences of these viruses and strongly reinforce the concept that viruses of murine origin and viruses of the gibbon ape leukemia virus-Simian sarcoma-associated virus group are closely related.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

5'-terminal nucleotide sequences of the Rauscher leukemia virus and gibbon ape leukemia virus genomes exhibit a high degree of correspondence

Lovinger¹,

Schochetman²

1979

J Virol

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“…GALV is a Gammaretrovirus which has been implicated in an outbreak of leukaemia in white handed gibbons (Hylobates lar), which were housed at the SEATO medical research facility in Bangkok in the late 1960＇s 26,27) . Subsequent to this initial outbreak, several other strains of GALV have been isolated from captive gibbons and other sub human primates in the US and Bermuda 28,29) . KoRV and GALV are so closely related that it seems almost certain that these two viruses share a common ancestor, and that there has been a cross species transmission between koalas and white handed gibbons 16,21) .…”

Section: The Link Between Korv and Gibbon Ape Leukaemia Virusmentioning

confidence: 99%

The Epidemiology of Koala Retrovirus

Simmons¹,

Young²,

McKee³

et al. 2011

JVE

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A novel Gammaretrovirus, named Koala retrovirus (KoRV) was identified in koalas in 2000. Subsequent testing has shown that KoRV appears to be widespread throughout the wild koala population in Australia. KoRV is apparently unique in that it is the only known example of an exogenous retrovirus which is actively undergoing the process of endogenisation. While there is currently little direct evidence that KoRV causes overt disease in koalas, it is possible or even likely that KoRV infection plays a significant role in the pathogenesis of various neoplasms and a variety of immunosuppressive disorders which are commonly diagnosed in koalas. It appears that KoRV may have arisen through the cross species transmission of a closely related retrovirus in a native Australian rodent, the grassland melomys. Both of these viruses are closely related to a third retrovirus, Gibbon ape leukaemia virus (GALV). GALV was first isolated in the late 1960＇s from captive gibbons in Thailand that were suffering from leukaemia. To date, the source of GALV remains unknown.

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“…The extensive similarity between GaLVH and GaLVBr predicts that all of the structural proteins of these viruses are similar. Reitz et al (15) conclude that these two viruses are the most closely related viruses of this group because the oligopyrimidine compositions oftheir 5'-complementary DNA transcripts are the same. Competition radioimmunoassay of the gp7O's of GaLVH and GaLVBr also shows these two isolates to be closely related (12).…”

Section: Figmentioning

confidence: 99%

Structural analysis of the genomes of gibbon ape and woolly monkey leukosis viruses

Sahagan¹,

Haseltine²

1979

J Virol

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Infectious retroviruses have been isolated from gibbon apes and a woolly monkey. Previous studies have shown that these isolates share some antigenic determinants and that they exhibit partial nucleic acid homology. To further define the relationships in this group of viruses, we compared the RNAs of the viruses of the woolly monkey-gibbon ape class by two-dimensional polyacrylamide gel electrophoresis of the large RNase T1-resistant oligonucleotides. The degree of sequence identity between the RNAs was determined by the similarity of the fingerprint patterns and in some cases by partial sequence analysis of individual oligonucleotides. This technique permitted us to determine the degree of sequence identity in related RNA species. These studies showed that as much as 80% of the genomes of gibbon ape leukosis virus-Halls' Island and gibbon ape leukosis virus-brain could be identical. The other viruses, simian sarcoma-associated virus, gibbon ape leukosis virus-Thailand, and gibbon ape leukosis virus-San Francisco, showed an extensive but somewhat lower degree of sequence identity (between 40 to 60% of the genomes.

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Gibbon ape leukemia virus-Hall's Island: new strain of gibbon ape leukemia virus

Cited by 26 publications

References 24 publications

5'-terminal nucleotide sequences of the Rauscher leukemia virus and gibbon ape leukemia virus genomes exhibit a high degree of correspondence

5'-terminal nucleotide sequences of the Rauscher leukemia virus and gibbon ape leukemia virus genomes exhibit a high degree of correspondence

The Epidemiology of Koala Retrovirus

Structural analysis of the genomes of gibbon ape and woolly monkey leukosis viruses

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