Gibberellin: inhibitor of an inhibitor of...?

Harberd, Nicholas P.; King, Kathryn E.; Carol, Pierre; Cowling, Rachel J.; Peng, Jinrong; Richards, Donald E.

doi:10.1002/(sici)1521-1878(199812)20:12<1001::aid-bies6>3.0.co;2-o

Cited by 104 publications

(78 citation statements)

References 38 publications

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“…Here we have shown that spy-7 and gar2-1 suppress the effects of gai on a wide range of these responses. Previously, we had outlined a model to explain the role of GAI and RGA (the GAI and RGA gene products) and associated signal transduction components in mediating GA responses (Peng et al, 1997;Harberd et al, 1998). This model proposed that GAI and RGA act as repressors of GA-regulated stem elongation and that the action of these repressors is opposed by GA.…”

Section: Discussionmentioning

confidence: 99%

“…According to this model, the gai protein is a mutant repressor with reduced sensitivity to GA. The model also proposed that the SPY gene product either acts downstream of the GAI and RGA repressors or modulates their activities (Peng et al, 1997;Harberd et al, 1998). This model was initially elaborated on the basis of stemelongation phenotypes.…”

Section: Discussionmentioning

confidence: 99%

“…GA is essential for normal plant growth regulation (Hooley, 1994), and studies of GA-deficient and GAresponse mutants have greatly advanced our understanding of GA action (Ross, 1994;Swain and Olszewski, 1996;Ross et al, 1997;Harberd et al, 1998). GA responses are dose dependent (Bethke and Jones, 1998).…”

mentioning

confidence: 99%

“…The phenotype of the Arabidopsis gai mutant mimics the effects of GA deficiency: gai plants are dwarfed and have dark-green leaves (Koornneef et al, 1985;Harberd, 1993, 1997a;Wilson and Somerville, 1995;Peng et al, 1997;Harberd et al, 1998). However, unlike GA-deficient mutants, gai mutants cannot be restored to normal phenotype by application of GA (Koornneef et al, 1985;Wilson and Somerville, 1995;Peng and Harberd, 1997a) and accumulate bioactive GAs (GA 1 and GA 4 ) to a higher level than do wild-type plants (Talon et al, 1990a).…”

mentioning

confidence: 99%

“…In addition, RGA, another Arabidopsis gene involved in GA signaling, encodes a protein (RGA) whose amino acid sequence is closely related to that of GAI. GAI and RGA appear to have overlapping roles as negative regulators of GA signaling (Peng et al, 1997;Harberd et al, 1998;Silverstone et al, 1998).…”

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confidence: 99%

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Extragenic Suppressors of the Arabidopsis gaiMutation Alter the Dose-Response Relationship of Diverse Gibberellin Responses1

et al. 1999

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Active gibberellins (GAs) are endogenous factors that regulate plant growth and development in a dose-dependent fashion. Mutant plants that are GA deficient, or exhibit reduced GA responses, display a characteristic dwarf phenotype. Extragenic suppressor analysis has resulted in the isolation of Arabidopsis mutations, which partially suppress the dwarf phenotype conferred by GA deficiency and reduced GA-response mutations. Here we describe detailed studies of the effects of two of these suppressors, spy-7 and gar2-1, on several different GA-responsive growth processes (seed germination, vegetative growth, stem elongation, chlorophyll accumulation, and flowering) and on the in planta amounts of active and inactive GA species. The results of these experiments show that spy-7 and gar2-1 affect the GA dose-response relationship for a wide range of GA responses and suggest that all GA-regulated processes are controlled through a negatively acting GA-signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Extragenic Suppressors of the Arabidopsis gaiMutation Alter the Dose-Response Relationship of Diverse Gibberellin Responses1

et al. 1999

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Plant GRAS and metazoan STATs: one family?

2000

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GRAS is a recently discovered family of plant‐specific proteins that play important regulatory roles in diverse aspects of plant development. Several of the motifs present in the GRAS proteins suggest that they function as transcription factors, although homology‐searching programs have revealed no significant similarity to any non‐plant proteins. Here we propose that the GRAS proteins are related to the Signal Transducers and Activators of Transcription (STAT) family of proteins. STATs are known in many non‐plant species, and act as intracellular intermediaries between extracellular ligands and the transcription and activation of genes. Our hypothesis is that the GRAS proteins perform this function in plants, with mechanisms similar to those of the animal STATs. If true, this hypothesis has important implications for the evolution of phosphotyrosine based signal transduction systems in eukaryotic organisms. BioEssays 22:573–577, 2000. © 2000 John Wiley & Sons, Inc.

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DELLA Proteins in Signalling

Alvey

Boulton

2008

Encyclopedia of Life Sciences

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DELLAs are a family of nuclear proteins that act as growth repressors throughout the life cycle of higher plants. Derepression is mediated through the gibberellic acid (GA)‐dependent degradation of DELLAs and the key components of the GA‐DELLA signalling pathway (the GA receptor and the F‐box protein involved in DELLA destruction) have recently been identified. It is becoming increasingly clear that DELLAs promote a plant's survival by integrating its growth responses to a wide range of endogenous and environmental signals.

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Gibberellin: inhibitor of an inhibitor of...?

Cited by 104 publications

References 38 publications

Extragenic Suppressors of the Arabidopsis gaiMutation Alter the Dose-Response Relationship of Diverse Gibberellin Responses1

Extragenic Suppressors of the Arabidopsis gaiMutation Alter the Dose-Response Relationship of Diverse Gibberellin Responses1

Plant GRAS and metazoan STATs: one family?

DELLA Proteins in Signalling

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