Giant vesicles prepared by nitroxide-mediated photo-controlled/living radical polymerization-induced self-assembly

Yoshida, Eri

doi:10.1007/s00396-013-3056-0

Cited by 43 publications

(35 citation statements)

References 53 publications

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“…This Tg originated from the crystallization of the hydrophilic PMAA blocks forming the vesicular surface, because the PMAA prepolymer showed the Tg at 163.0°C. The Tg of the PMAA blocks was replaced by the Tg at 142.4°C based on the random copolymer blocks during the second scan [40]. It was found that these Tgs were dependent on the cross-linking density.…”

Section: Resultsmentioning

confidence: 99%

“…The vesicles comprised of poly(methacrylic acid)-block-poly(alkyl methacrylate-random-methacrylic acid) had a high stability and long lifetime of over 1 year without cross-linking. The polymer giant vesicles also had some similarities to the lipid bilayer of the biomembrane regarding the budding separation [42,46] and fusion [40] when responding to external variations. These morphological changes in the vesicles were accounted for by the critical packing shape defined by Israelachvili [47].…”

Section: Introductionmentioning

confidence: 96%

“…Such giant vesicles formed by the reconstruction of natural lipids have been widely used for the purpose of elucidating the properties and functions of the biomembranes [32][33][34][35][36][37][38][39]. In recent years, the giant vesicles formed by synthetic polymer surfactants of amphiphilic random block copolymers have been prepared by the photopolymerization-induced self-assembly technique [40][41][42][43][44][45][46]. The vesicles comprised of poly(methacrylic acid)-block-poly(alkyl methacrylate-random-methacrylic acid) had a high stability and long lifetime of over 1 year without cross-linking.…”

Section: Introductionmentioning

confidence: 99%

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Cross-linking effect of hydrophobic cores on morphology of giant vesicles formed by amphiphilic random block copolymers

Yoshida

2015

Colloid Polym Sci

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The cross-linking effect of the hydrophobic cores on the morphology of giant vesicles was explored using amphiphilic poly(methacrylic acid)-block-poly (methyl methacrylate-random-methacrylic acid), PMAAb-P(MMA-r-MAA), and ethylene glycol dimethacrylate (EGMA) as the cross-linking agent. Spherical vesicles without cross-linking were transformed into large contorted vesicles with a rough surface by the crosslinking of the P(MMA-r-MAA) blocks with EGMA. An increase in the EGMA ratio promoted a further transformation into huge spherical particles with a smooth surface, followed by smaller partly joined particles. A still higher EGMA ratio caused the joining of particles along with a further decrease in the particle size. The cross-linking of the hydrophobic blocks also dominated the crystallization of the hydrophilic PMAA blocks. The thermal analysis demonstrated that the glass transition temperature of the PMAA blocks increased with the EGMA ratio for the identical PMAA block length. The crystallinity of the hydrophobic cores enhanced that of the hydrophilic surface.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Cross-linking effect of hydrophobic cores on morphology of giant vesicles formed by amphiphilic random block copolymers

Yoshida

2015

Colloid Polym Sci

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“…Recently, light energy has been applied in PISA and has opened up new opportunities for the production of vesicles at lower temperatures (Figure B), which are not readily accessible to traditional thermally powered PISA . The first attempt at photoinitiated PISA (photo‐PISA) for the construction of vesicles at room temperature was realized using high power (500 W) UV light to initiate the nitroxide‐mediated polymerization of methyl methacrylate (MMA) and methacrylic acid (MAA) in a water/ethanol solvent system . Later, a milder photo‐PISA system was developed, in which the photoinitiators were activated by light to generate the necessary radicals.…”

Section: Pisa An Ex Novo Strategy For Vesicle Formation Growth Andmentioning

confidence: 99%

Polymerization‐Induced Self‐Assembly for Artificial Biology: Opportunities and Challenges

Cheng

Pérez–Mercader

2018

Macromol. Rapid Commun.

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The study of the origin of life and current undergoing efforts to produce artificial chemical systems mimicking the behavior of natural living systems have emerged as a hot topic at the interfaces among disciplines. In these two problems, the spontaneous generation of free-energy gradients by means of material interfaces plays a central role and, until recently, hindered progress. Polymerization-induced self-assembly (PISA) is a promising strategy for the formation of polymeric vesicles from a homogeneous mixture which, in the form of artificial biology, may reflect and inform the generation of vesicular structures in primitive Earth. In the past few years, PISA has been used for the construction of biomimetic vesicles or artificial protocells in artificial biology. These not only give inspiration for decoding some aspects of the origin of life in arbitrary environments but also offer potential for building innovative functional systems with a wide variety of applications. In this review, a brief summary of some of the unique possibilities offered by PISA and the development of PISA in exploration of artificial biology is provided, while some of the allied current challenges, limitations, and opportunities in this exciting field are highlighted.

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“…Micrometer-sized giant vesicles comprised of amphiphilic poly(methacrylic acid)-block-poly(alkyl methacrylaterandom-methacrylic acid) random block copolymers have been demonstrated to be useful as artificial models of biomembranes for cells and organelles based on the similarities in their size and structure [17][18][19][20][21]. The giant vesicles consisting of the amphiphilic random block copolymers with the molecular weight of ca.…”

Section: Introductionmentioning

confidence: 99%

Enhanced permeability of Rhodamine B into bilayers comprised of amphiphilic random block copolymers by incorporation of ionic segments in the hydrophobic chains

Yoshida

2015

Colloid Polym Sci

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The permeability of Rhodamine B (Rh) into bilayers comprised of amphiphilic block copolymers was explored using ionic segments incorporated in the hydrophobic chains. The amphiphilic block copolymer consisting of a hydrophilic poly(methacrylic acid) block and a hydrophobic poly(methyl methacrylate-random-methacrylic acid) block containing 0.2 mol% units of the 3-sulfopropyl methacrylate potassium salt (SpMA) produced giant vesicles by photopolymerizationinduced self-assembly in an aqueous methanol solution. The spherical vesicles were transformed into films as the SpMA ratio increased. The SpMA units incorporated in the hydrophobic chains enhanced the Rh permeability into the bilayer, whereas the vesicles without SpMA units captured no Rh molecules. However, the Rh was released from the hydrophobic phases in the isolation process of the bilayers by repeated sedimentation-redispersion. The permeability enhancement was attributed to the pore formation in the bilayers by the capture and release of the Rh by the SpMA units in the hydrophobic phases.

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Giant vesicles prepared by nitroxide-mediated photo-controlled/living radical polymerization-induced self-assembly

Cited by 43 publications

References 53 publications

Cross-linking effect of hydrophobic cores on morphology of giant vesicles formed by amphiphilic random block copolymers

Cross-linking effect of hydrophobic cores on morphology of giant vesicles formed by amphiphilic random block copolymers

Polymerization‐Induced Self‐Assembly for Artificial Biology: Opportunities and Challenges

Enhanced permeability of Rhodamine B into bilayers comprised of amphiphilic random block copolymers by incorporation of ionic segments in the hydrophobic chains

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