Giant Vesicles Containing Magnetic Nanoparticles and Quantum Dots: Feasibility and Tracking by Fiber Confocal Fluorescence Microscopy

Abstract

Hybrid vesicles: Magnetic nanoparticles (γ‐Fe2O3) and quantum dots (CdSe/ZnS) can be entrapped in stable vesicles by emulsion processes. The hybrid vesicles (HVs) have distinct magnetic and fluorescence properties (see images; scale bars: 10 μm). Fluorescence detection allows magnetic manipulation and tracking of the HVs in vivo by both magnetic resonance and fluorescence imaging.

Self‐Assembly of Soft Hybrid Materials Directed by Light and a Magnetic Field

“…Several groups also reported liposomes with magnetic nanoparticles embedded in the bilayer membrane. [ 11 ] In this study, we report a hybrid material that is composed of iron oxide (magnetite) nanoparticles and vesicles composed of amphiphilic cyclodextrins (CDs). Cyclodextrin vesicles ( CDV ) with an average diameter of 150-200 nm are obtained by dispersing amphiphilic β -CD in aqueous solution.…”

Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery

“…The differences observed in the fluorescence images are much more substantial than in the MR images, due to the low background signals associated with NIR imaging. Although these in vivo results are preliminary, the data provide promise for further in vivo applications due to the prolonged residence time in blood circulation displayed by MHN relative to similar liposomal hybrid systems [17] In summary, micellar hybrid nanoparticles that contain MN, QD, and anti-cancer drug DOX within a single PEG-modified phospholipid micelle have been prepared. The hydrophobic chains of the PEG-phospholipids interact strongly with hydrophobic chains attached to the MN and QD, providing high dispersibility and stability for in vitro and in vivo applications.…”

“…[17,18] By contrast, DOXincorporated F3-MHN display cytotoxicity which is significantly greater than that of equivalent quantities of free DOX or DOX-incorporated untargeted MHN (see Supporing Information Figure S4). …”

“…[10][11][12][13][14][15] While these nanocomposites have been used for in vitro magnetic cell separation and in vitro cell targeting, there are limited in vivo studies, particularly for cancer imaging and therapy, due to poor stability or short systemic circulation times generally observed for these more complicated nanostructures. [16,17] Herein, we introduce long-circulating, micellar hybrid nanoparticles (MHN) that contain MN, QD, and the anti-cancer drug doxorubicin (DOX) within a single …”

Lamellar Lα Mesophases Doped with Inorganic Nanoparticles

“…Owing to their small size, these fluorescent particles (with an appropriate hydrophobic functionalization) are good candidates for insertion within lipid or surfactant membranes. [50] It is noteworthy that the QDs were inserted within the (solvent-free) membrane of giant vesicles filled with magnetic nanoparticles, which can potentially be used as contrast agents for MRI and optical imaging techniques. …”