Giant variant of acquired perforating dermatosis in a patient with diabetes mellitus

Abstract

Perforan dermatozlar, kollajen, elastin, fibrin gibi dermal bileşenlerin transepidermal eliminasyonu ile karakterize bir grup hastalıktır. Perforan dermatozlar, temelde transepidermal eliminasyon ile karakterize olan (primer perforan dermatoz) veya klinik seyirleri sırasında transepidermal eliminasyonun sekonder olarak geliştiği deri hastalıkları olarak ortaya çıkabilirler (sekonder perforan dermatoz). Perforan dermatozlar primer olarak reaktif perforan kollajenoz (RPK), elastozis perforans serpiginoza (EPS), perforan folikülit (PF) ve edinsel perforan dermatoz (EPD) olmak üzere dört ana hastalık formunu kapsar. Bunlardan genellikle diabetes mellitus (DM) ve kronik böbrek yetmezliğiyle (KBY) ilişkilendirilen Perforating dermatoses are a group of diseases characterized by transepidermal elimination of dermal components such as collagen, elastin and fibrin. Perforating dermatoses primarily include four main forms: Reactive perforating collagenosis, elastosis perforans serpiginosa, perforating folliculitis and acquired perforating dermatosis. There is limited data about perforating dermatoses in the literature. Because of their rare appearance, they can be easily misdiagnosed. Acquired perforating dermatosis is a systemic disease such as diabetes and chronic renal failure; and it should be considered in case of pruritic papulonodules and giant plaques with central crater in a patient. In addition to the treatment of underlying disease in the first stage; narrow band ultraviolet B (nbUVB) is evaluated to be effective in these cases. Based on its rare occasions, we submit a giant variant of acquired perforating dermatosis with a collagen fiber predominant elimination pattern, which is treated with nbUVB.

Perforating Gout: Expanding the Differential for Transepidermal Elimination

“…Two large series [ 11 , 12 ] confirm renal disease to be by far the most common cause of perforating dermatosis, followed by diabetes and malignancy. Many case reports and smaller series of acquired perforating dermatoses were identified [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], again most commonly associated with renal disease and/or diabetes [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. Associations with other systemic diseases have also been observed.…”