Giant thoracic ganglioneuroma with lymph node infiltration of a child: a case report

Abstract

Background Ganglioneuroma is a rare neurogenic tumor which could grow into massive size in the thorax with minimal or no symptoms. Resection of these tumors will be challenging in view of large size and vascular encasement. Here, we report resection of a thoracic ganglioneuroma in a child with infiltration of spinal canal and lymph node metastasis, which is a very rare occurrence. Case presentation A 3-year and 10-month-old girl presented with a left side thoracic mass with minimal symptoms and signs. After the initial imaging with ultrasound scan and cross-sectional imaging, she had a true cut biopsy of the lesion confirming the diagnosis of ganglioneuroma. On exploration, she had a paraspinal thoracic mass extending from level of arch of aorta down to diaphragm with evidence of tumor infiltration of the intercostal spaces and spinal canal in multiple vertebral levels. Pathologically, she had infiltrated lymph nodes which were encircling the lower thoracic aorta. The tumor was resected successfully, and she recovered with a good functional status. Conclusion Thoracic ganglioneuroma has a good prognosis after complete resection even with spinal canal and lymph node infiltration. The resection could be arduous in case of massive size and vascular encasement; hence, benefit versus risk of complete resection should be carefully weighed.

Large posterior mediastinal ganglioneuroma with intradural cervical spine extension: A rare case report and review of literature

“…Ganglioneuroma (GN) is a rare neurogenic tumor that arises from the neural crest cells of the sympathetic ganglia or, even more rarely, the adrenal medulla; yet, it is benign in nature [ 1 ]. Histologically, they are benign tumors made up of mature schwannian stroma and ganglion cells [ 2 ].…”