Giant squamous cell carcinoma of the gallbladder: A case report

Abstract

BACKGROUNDGallbladder cancer is the most common malignant tumor of the biliary tract. The majority of cases are adenocarcinoma. Squamous cell carcinoma is the histological type present in 12% of all neoplasias accounting for approximately 12% of gallbladder neoplasms. It can occur in its pure form reaching 1%-3% of the tumors. Many patients are at an advanced stage when diagnosed and have bad therapeutic efficacy.CASE SUMMARYA 45-year-old male patient presented with left flank pain for 1 year and irradiated to the mesogastric region. He denied fever, vomiting, and any other intestinal changes. He reported a weight loss of 10 kg in a period of 7 mo. He denied alcoholism, smoking, drug use, or prior illness. Computed tomography of the abdomen showed in the gallbladder fossa a voluminous mesogastric heterogeneous collection that had a thick and irregular capsule with liquid and gaseous contents. A predominantly hypoattenuating rounded material with partially calcified margins measuring about 2.0 cm related to gallstone was also emphasized. No lymphadenomegalies or free fluid was observed in the abdominal cavity. Patient underwent laparotomy where a huge tumor was observed affecting the transverse colon and gallbladder. This mass was resected en bloc removing gallbladder and transverse colon together with corresponding mesocolon and regional lymphadenectomy. There were no complications in the postoperative period. Although oncological treatment was performed, the patient died 6 mo after surgery.CONCLUSIONSquamous cell carcinoma represents a rare disease. Patients often present with large, bulky tumors with involvement of adjacent organs. In spite of progress in surgical techniques and adjuvant chemotherapy, the prognosis remains poor.

Laparoscopic cholecystectomy for giant gallbladder: A case report

“…Giant gallbladders are associated with various obstructions of the cystic duct of the bile duct, such as stones, parasites, or tumors. [1,7,8] There are also sporadic reports of gallbladder neck gangliocytopenia leading to dilated gallbladder. [6] In this patient, there was no cystic duct obstruction or any other underlying disease.…”

Gallbladder adenocarcinoma with upper abdominal pain: A case report

“…The clinical manifestation of gallbladder cancer is frequently ambiguous or delayed in comparison with the pathologic progression, which leads to advanced staging and a poor prognosis at the time of diagnosis [1] , [10] , [11] . The majority of patients present to the hospital with a vague upper abdominal pain or a palpable tumor on physical examination; this may be an accidental discovery on imaging or a histological finding [12] , [13] . Jaundice, abdominal lump, anorexia, and weight loss are frequent signs of advanced stages.…”

The giant resectable carcinoma of gall bladder—a case report

“…Chapman et al reported a 10 × 6.5 × 0.5 cm papillary, circumferential tumor located primarily in the body and neck of the 18 cm large gallbladder and Hsu et al reported a 16.4 × 13.6 × 7.8 cm GB with poorly differentiated adenocarcinoma [ 22 , 24 ]. Junior et al reported a case of giant squamous cell carcinoma of gall bladder infiltrating the transverse colon, however the size was not mentioned [ 26 ]. Based on the sizes mentioned in indexed literature, it appears that our case is the largest resectable GBC reported till date.…”