Giant-spin nonlinear response theory of magnetic nanoparticle hyperthermia: A field dependence study

Carrião, Marcus S.; Aquino, V. R. R.; Landi, Gabriel T.; Verde, E. L.; Bakuzis, Andris F.

doi:10.1063/1.4982357

Cited by 29 publications

(30 citation statements)

References 55 publications

(141 reference statements)

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“…According to the literature, [28] for monodisperse spherical nanoparticles one can assume that the packing of the nanoparticles in the powder configuration corresponds to a particle volume fraction close to φ = 0.64 (although the nanoparticles are not perfectly spherical or monodisperse this is considered to be a good approximation). Recall that unlike the case of the magnetic fluid in which the anisotropic axes are oriented towards the freezing field (longitudinal case [27]), in the case of the powdered sample the axes are estimated to be in the random configuration. For the colloid one can observe an increase of the effective magnetic anisotropy the higher the particle concentration.…”

Section: B Anisotropy Temperature Dependence and The Callen-callen Modelmentioning

confidence: 99%

Magnetic interaction and anisotropy axes arrangement in nanoparticle aggregates can enhance or reduce the effective magnetic anisotropy

Aquino

Figueiredo

Coaquira

et al. 2020

Journal of Magnetism and Magnetic Materials

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The magnetic response of nanostructures plays an important role on biomedical applications being strongly influenced by the magnetic anisotropy. In this work we investigate the role of temperature, particle concentration and nanoparticle arrangement forming aggregates in the effective magnetic anisotropy of Mn-Zn ferrite-based nanoparticles. Electron magnetic resonance and coercivity temperature dependence analyses, were critically compared for the estimation of the anisotropy. We found that the temperature dependence of the anisotropy follows the Callen-Callen model, while the symmetry depends on the particle concentration. At low concentration one observes only an uniaxial term, while increasing a cubic contribution has to be added. The effective anisotropy was found to increase the higher the particle concentration on magnetic colloids, as long as the easy axis was at the same direction of the nanoparticle chain. Increasing even further the concentration up to a highly packed condition (powder sample) one observes a decrease of the anisotropy, that was attributed to the random anisotropy axes configuration.

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Section: B Anisotropy Temperature Dependence and The Callen-callen Modelmentioning

confidence: 99%

Magnetic interaction and anisotropy axes arrangement in nanoparticle aggregates can enhance or reduce the effective magnetic anisotropy

Aquino

Figueiredo

Coaquira

et al. 2020

Journal of Magnetism and Magnetic Materials

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“…Atkinson [68] identified that the biological range of AMF applications for humans should have a product of field strength and frequency less than 485 kA/mÁkHz. However, this is currently an area of debate as the value can be adjusted for coil diameter, tissue diameter, and electrical conductivity of the tissue [69][70][71]. As described by Carrião et al [70], the free current loss is proportional to the square of the distance from the coil axis and thus a better estimation for the critical field for biomedical applications can be found using the equation Hf < ð0:150=rÞ Á 485kA/mÁkHz.…”

Section: Future Directionsmentioning

confidence: 99%

“…However, this is currently an area of debate as the value can be adjusted for coil diameter, tissue diameter, and electrical conductivity of the tissue [69][70][71]. As described by Carrião et al [70], the free current loss is proportional to the square of the distance from the coil axis and thus a better estimation for the critical field for biomedical applications can be found using the equation Hf < ð0:150=rÞ Á 485kA/mÁkHz. Additionally, field conditions viable for human use could be expanded in the future as coil design is an area of active development.…”

Section: Future Directionsmentioning

confidence: 99%

Evaluation of magnetic nanoparticles for magnetic fluid hyperthermia

Lanier

Korotych

Monsalve

et al. 2019

International Journal of Hyperthermia

115

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Background: Magnetic nanoparticles (MNPs) generate heat when exposed to an alternating magnetic field. Consequently, MNPs are used for magnetic fluid hyperthermia (MFH) for cancer treatment, and have been shown to increase the efficacy of chemotherapy and/or radiation treatment in clinical trials. A downfall of current MFH treatment is the inability to deliver sufficient heat to the tumor due to: insufficient amounts of MNPs, unequal distribution of MNPs throughout the tumor, or heat loss to the surrounding environment. Objective: In this study, the objective was to identify MNPs with high heating efficiencies quantified by their specific absorption rate (SAR). Methods: A panel of 31 commercially available MNPs were evaluated for SAR in two different AMFs. Additionally, particle properties including iron content, hydrodynamic diameter, core diameter, magnetic diameter, magnetically dead layer thickness, and saturation mass magnetization were investigated. Results: High SAR MNPs were identified. For SAR calculations, the initial slope, corrected slope, and Box-Lucas methods were used and validated using a graphical residual analysis, and the Box-Lucas method was shown to be the most accurate. Other particle properties were identified and examined for correlations with SAR values. Positive correlations of particle properties with SAR were found, including a strong correlation for the magnetically dead layer thickness. Conclusions: This work identified high SAR MNPs for hyperthermia, and provides insight into properties which correlate with SAR which will be valuable for synthesis of next-generation MNPs. SAR calculation methods must be standardized, and this work provides an in-depth analysis of common calculation methods.

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“…Em geral, esse monitoramento é realizado com a Ressonância Magnética (RM) [3], que é uma técnica cara. Entretanto, tal procedimento não pode ser utilizado no caso da hipertermia magnética com nanopartículas [4][5][6][7][8][9][10], já que esta nanoterapia depende da rotação dos momentos magnéticos das nanopartículas sob ação de campo alternado. Logo, neste caso, não há como ter geração de calor pois o campo magnético de alta intensidade do ímã permanente da RM impossibilita a rotação dos momentos magnéticos das nanopartículas.…”

Section: Introductionunclassified

“…Assim, métodos baseados em sistema de processamento de sinais, simples e de baixo custo, como o sistema de imagens por ultrassom, torna-se uma alternativa interessante. Note, adicionalmente, que o ultrassom pode ser capaz de fornecer uma estimativa de temperatura interna em tempo quase real e ser combinada com várias nanoterapias térmicas, como a hipertermia magnética [4][5][6][7][8][9][10] ou a fototérmica [11].…”

Section: Introductionunclassified

Ultrassom Diagnóstico Como Técnica Para a Estimativa Não Invasiva de Temperatura Visando Nanoterapias Térmicas

Faria¹,

Gonalves²,

Capistrano³

et al. 2018

Anais Do v Congresso Brasileiro De Eletromiografia E Cinesiologia E X Simpósio De Engenharia Biomédica

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Resumo: A medicina térmica trata do uso clínico da distribuição seletiva de calor para o tratamento de doenças, em particular câncer. Esta terapia foi recentemente utilizada como coadjuvante porque apresenta sinergia em radioterapia e quimioterapia. Dentre os problemas mais importantes esta o monitoramento não invasivo da distribuição de calor. A técnica tradicional é a ressonância magnética nuclear, que é dispendiosa e não pode ser utilizada em hipertermia magnética com nanopartículas. Assim, a estimativa de temperatura não invasiva usando ultrassom de eco-pulso se apresenta como uma excelente alternativa. A metodologia deste trabalho baseia-se na medição do deslocamento de estruturas internas em imagens de ultrassom em função da temperatura, para amostras de tecido biológico de suíno, que foram submetidas ao aumento de temperatura em um banho de água, enquanto analisadas pelo método de ultrassom de pulso-eco, obtido por meio de um equipamento de ultrassom clínico ordinário, para formar as imagens a diferentes temperaturas, na faixa de 37,0 ° C a 50,0 ° C, com intervalos de variação de 0,5 ° C ± 0,1 ° C. Por meio de um algoritmo de correlação bidimensional, com o auxílio de um software para processamento de imagens, foi possível calcular os deslocamentos das regiões características das imagens das amostras em função da temperatura. Os resultados preliminares mostram que é possível relacionar a variação de temperatura com o deslocamento da amostra nesta condição, e sugerem que esta técnica pode ser usada para monitorar a temperatura interna dos tecidos in vivo para aplicações em hipertermia magnética ou terapia fototérmica.Palavras-chave Deslocamento aparente, Estimativa não invasiva de temperatura, Ultrassom pulso-eco.Abstract: Thermal medicine deals with the clinical use of selective heat delivery for the treatment of diseases, in particular cancer. This therapy has recently been used as a coadjuvant because it presents synergy in radiotherapy and chemotherapy. Among the most important problems is the non-invasive monitoring of heat delivery. The traditional technique is nuclear magnetic resonance, which is expensive, and cannot be used in magnetic hyperthermia with nanoparticles. Thus, the non-invasive temperature estimation using pulse-echo ultrasound presents itself as an excellent alternative. The methodology of this work is based on measuring the displacement of internal structures in ultrasound images as a function of temperature, for samples of biological swine tissue, which were submitted to temperature increase in a water bath, while analyzed by the pulse-echo ultrasound method, obtained by means of an ordinary clinical ultrasound equipment, in order to form the images at different temperatures, in the range of 37.0 ° C to 50.0 ° C, with intervals of variation of 0.5 ° C ± 0.1 ° C. By means of a twodimensional correlation algorithm, with the aid of a software for image processing, it was possible to calculate the displacements of the characteristic regions of the images of the samples as a function of...

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Giant-spin nonlinear response theory of magnetic nanoparticle hyperthermia: A field dependence study

Cited by 29 publications

References 55 publications

Magnetic interaction and anisotropy axes arrangement in nanoparticle aggregates can enhance or reduce the effective magnetic anisotropy

Magnetic interaction and anisotropy axes arrangement in nanoparticle aggregates can enhance or reduce the effective magnetic anisotropy

Evaluation of magnetic nanoparticles for magnetic fluid hyperthermia

Ultrassom Diagnóstico Como Técnica Para a Estimativa Não Invasiva de Temperatura Visando Nanoterapias Térmicas

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