Giant somatosensory evoked potentials are uncommon in patients with post-anoxic coma and paroxysmal electroencephalographic activity

Popa, Irina; Jung, Julien; Jeannin-Mayer, Sophie; Boulogne, Sébastien; André‐Obadia, Nathalie

doi:10.1016/j.neucli.2018.05.027

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“…In a small case study giant SSEPs were suggested to be associated with paroxysmal activity on EEG and associated with poor outcome in anoxic brain injury (20). However, more recently, giant SSEPs defined as N20-P24 peak-to-peak amplitudes >5.5 µV were considered uncommon in post anoxic encephalopathy with paroxysmal activity on EEG (21).…”

Section: Introductionmentioning

confidence: 99%

Relevance of Somatosensory Evoked Potential Amplitude After Cardiac Arrest

et al. 2020

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Objective: We present relations of SSEP amplitude with neurological outcome and of SSEP amplitude with EEG amplitude in comatose patients after cardiac arrest. Methods: This is a post hoc analysis of a prospective cohort study in comatose patients after cardiac arrest. Amplitude of SSEP recordings obtained within 48-72 h, and EEG patterns obtained at 12 and 24h after cardiac arrest were related to good (CPC 1-2) or poor (CPC 3-5) outcome at 6 months. In 39% of the study population multiple SSEP measurements were performed. Additionally, SSEP amplitude was related to mean EEG amplitude. Results: We included 138 patients (77% poor outcome). Absent SSEP responses, a N20 amplitude <0.4 µV within 48-72 h, and suppressed or synchronous EEG with suppressed background at 12 or 24 h after cardiac arrest were invariably associated with a poor outcome. Combined, these tests reached a sensitivity for prediction of poor outcome up to 58 at 100% specificity. N20 amplitude increased with a mean of 0.55 µV per day in patients with a poor outcome, and remained stable with a good outcome. There was no statistically significant correlation between SSEP and EEG amplitudes in 182 combined SSEP and EEG measurements (R 2 < 0.01). Conclusions: N20 amplitude <0.4 µV is invariably associated with poor outcome. There is no correlation between SSEP and EEG amplitude. Significance: SSEP amplitude analysis may contribute to outcome prediction after cardiac arrest.

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Section: Introductionmentioning

confidence: 99%