Giant pulmonary pleomorphic liposarcoma: A case report and literature review

Pleomorphic Liposarcoma Unraveled: Investigating Histopathological and Immunohistochemical Markers for Tailored Diagnosis and Therapeutic Innovations

“…However, researchers suggest that pre-operative radiotherapy should be taken into consideration in these malignant lesions, in order to reduce the tumor volume and obtain surgical resection margins [ 69 ]. Among pleomorphic liposarcomas with peculiar locations, malignant adipocytic tumors of the viscera require special attention [ 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ]. We identified two primary pleomorphic liposarcomas of the lung, reported by Li B. et al and Dey T. et al, both of them identified in male patients with no history of smoking or alcohol abuse [ 71 , 72 ].…”

“…Among pleomorphic liposarcomas with peculiar locations, malignant adipocytic tumors of the viscera require special attention [ 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ]. We identified two primary pleomorphic liposarcomas of the lung, reported by Li B. et al and Dey T. et al, both of them identified in male patients with no history of smoking or alcohol abuse [ 71 , 72 ]. The patients presented with shortness of breath and chest pain, and the tumors were described as large, hypodense masses identified using a CT scan [ 71 , 72 ].…”

“…We identified two primary pleomorphic liposarcomas of the lung, reported by Li B. et al and Dey T. et al, both of them identified in male patients with no history of smoking or alcohol abuse [ 71 , 72 ]. The patients presented with shortness of breath and chest pain, and the tumors were described as large, hypodense masses identified using a CT scan [ 71 , 72 ]. The two patients received chemotherapy, followed by surgical resection; however, one of them developed a retroperitoneal metastasis 7 months after treatment [ 72 ].…”

“…The two patients received chemotherapy, followed by surgical resection; however, one of them developed a retroperitoneal metastasis 7 months after treatment [ 72 ]. Upon histopathological examination, both lesions were highly suggestive of pleomorphic liposarcoma [ 71 , 72 ]. An ancillary study revealed intense S100 positivity and a mutant p53 immunophenotype within the tumor cells of both lesions described above [ 72 ].…”